A Randomized Prospective Trial to Assess the Impact of Transurethral Resection in Narrow Band Imaging Modality on Non–Muscle-Invasive Bladder Cancer Recurrence

Naselli, Angelo; Introini, Carlo; Timossi, Luca; Spina, Bruno; Fontana, Vincenzo; Pezzi, Riccardo; Germinale, F.; Bertolotto, Franco; Puppó, P.

doi:10.1016/j.eururo.2012.01.018

Cited by 107 publications

(72 citation statements)

References 18 publications

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“…There have been few previous comparisons of recurrence in NMIBC following NBI-TUR and WLI-TUR (4). The significantly lower recurrence rate with NBI-TUR compared to WLI-TUR may be due to the significantly higher tumor detection rate with NBI-TUR found in the NMIBC patients in the present study and in previous studies (4)(5)(6)(7)(8)(9).…”

Section: Discussionmentioning

confidence: 32%

“…The tumor recurrence rate at 3 months after TUR in NMIBC may also reflect the skill of the surgeon (4,11,12). Without additional post-operative treatment, recurrence rates of 3.4 to 20.6% and 7.4 to 45.8% have been found in patients with single and multiple tumors, respectively (11).…”

Section: Discussionmentioning

confidence: 99%

“…NBI is useful for the identification and evaluation of early-stage cancer in gastrointestinal endoscopy (3), and the utility of NBI for increasing tumor detection and decreasing recurrence compared with WLI has been shown in non-muscle invasive bladder cancer (NMIBC) (4)(5)(6)(7)(8)(9). However, it is unclear if transurethral resection (TUR) using NBI (NBI-TUR) reduces the tumor recurrence rate compared with TUR under conventional WLI (WLI-TUR).…”

Section: Introductionmentioning

confidence: 99%

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Advantage of transurethral resection with narrow band imaging for non-muscle invasive bladder cancer

et al. 2015

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Abstract. The aim of the present study was to compare the benefits of transurethral resection (TUR) under narrow band imaging (NBI-TUR) and TUR under conventional white light imaging (WLI-TUR) for non-muscle invasive bladder cancer (NMIBC). The study cohort consisted of 135 patients with NMIBC who were followed up for ≥1 year after TUR and who received no additional post-operative treatment. In the WLI-TUR group (n=78), systematic intravesical observation under WLI was followed by a multiple site biopsy (MSB), after which lesions detected as positive findings were resected completely under WLI. In the NBI-TUR group (n=57), similar observation under WLI was followed by systematic intravesical observation under NBI. Following MSB under NBI, TUR was performed for all lesions detected as positive findings under NBI. The sensitivity, specificity, positive-predictive value, negative-predictive value (NPV) and accuracy in the NBI-TUR group were calculated using results from the cystoscopical and pathological examinations of MSB samples under WLI and NBI. The tumor recurrence rate was analyzed in the two groups. Background factors did not differ significantly between the two groups, with the exception of the observation period (31.0 vs. 15.0 months; P<0.01). The procedure under NBI exhibited significantly higher sensitivity (95.0 vs. 70.0%; P<0.01) and NPV (97.1 vs. 86.8%; P<0.01) compared with the procedure under WLI. The 1-year recurrence rate in the NBI-TUR group was significantly lower than that in the WLI-TUR group (21.1 vs. 39.7%; P=0.016). In conclusion, the present study indicated that NBI-TUR is more advantageous than conventional WLI-TUR for patients with NMIBC.

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Section: Discussionmentioning

confidence: 32%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Advantage of transurethral resection with narrow band imaging for non-muscle invasive bladder cancer

et al. 2015

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“…[32] Herr et al [33] evaluated 103 patients with recurrent NMIBC, and although 87% of the recurrences were able to be seen with WLC, 100% of the lesions were visualized with NBI. Naselli et al [34] performed a prospective randomized control study powered to report a 10% difference in recurrence at 1 year and, indeed, found the recurrence risk using NBI versus WLC during TURBT to be 33% versus 51%, respectively. Montanari et al [35] later confirmed these results with a prospective trial that reported recurrence rates at 1 year of 35% with NBI compared with 50% with only WLC.…”

Section: Narrow Band Imaging (Nbi)mentioning

confidence: 99%

Approaching the optimal transurethral resection of a bladder tumor

Jurewicz

Soloway

2014

Turkish Journal of Urology

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A complete transurethral resection of a bladder tumor (TURBT) is essential for adequately diagnosing, staging, and treating bladder cancer. A TURBT is deceptively difficult and is a highly underappreciated procedure. An incomplete resection is the major reason for the high incidence of recurrence following initial transurethral resection and thus to the suboptimal care of our patients. Our objective was to review the preoperative, intraoperative, and postoperative considerations for performing an optimal TURBT. The European Association of Urology, Society of International Urology, and The American Urological Association guidelines emphasize a complete resection of all visible tumor during a TURBT. This review will emphasize the various techniques and treatments, including photodynamic cystoscopy, intravesical chemotherapy, and a perioperative checklist, that can be used to help to enable a complete resection and reduce the recurrence rate. A Medline/PubMed search was completed for original and review articles related to transurethral resection and the treatment of non-muscle-invasive bladder cancer. The major findings were analyzed and are presented from large prospective, retrospective, and review studies.

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“…Ezeken túl el nem hanyagolható há-nyadot képeznek a műtét során észre nem vett apró daganatok is. Amellett, hogy újabb műtét szükséges ahhoz, hogy a beteg daganatmentessé váljon, nem kerülhető el az a tény sem, hogy a beavatkozások ismétlése jelentős terhet ró az amúgy is minimális tartalékokkal rendelkező egészségügyi rendszerünkre, nem beszélve a beteg szociális, pszichés és ál-talános egészségi állapotáról (8,9,10). Az utánkövetés során a képalkotó eljárások mellett alapvető fontosságú a vizeletcitológia (G3 tumor esetén) és a cisztoszkópia.…”

unclassified

Ígéretes képalkotó technika nem-izominvazív hólyagdaganatok diagnosztikájában: az NBI (narro band imaging) alkalmazása az urológiában

Mosonyi¹,

Szepesváry²,

Kerényi³

et al. 2017

Magyar Urológia

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BevezetésA hólyagdaganat a húgyutakban leggyakrabban előforduló rosszindulatú tumor. Az idősebb generáció betegsége, mivel diagnóziskor az átlagéletkor 70 év. Ugyanakkor a fiatalabb korban felfedezett tumorok általában jobban differenciáltak, alacsonyabb grádusúak és ezáltal jobb prognózissal bírnak. Férfiak esetében négyszer gyakrabban figyelhető meg, mint nőknél, afroamerikaiaknál feleannyira gyakori (1). Az újonnan diagnosztizált betegek 75%-ánál a daganat felszínes (nonÍgéretes képalkotó technika a nem-izominvazív hólyagdaganatok diagnosztikájában: az NBI (narrow band imaging) alkalmazása az urológiában Mosonyi Péter dr., Szepesváry Zsolt dr., Kerényi Gábor dr., Lacó László dr.Petz Aladár Megyei Oktató Kórház, Urológiai Osztály, Győr (osztályvezető: Szepesváry Zsolt dr.) ÖSSZEFOGLALÁS Célkitűzés: A nem izominvazív hólyagdaganatok (nonmuscle invasive bladder tumor -NMIBT) utánkövetése során viszonylag magas számban észlelhető recidíva. Ennek csökken-tése céljából az utóbbi években számos eljárás került kidolgozásra vagy bevezetésre a klinikai gyakorlatban. Ezek részben biomarkerek és az utánkövetésben van szerepük, részben pedig a tumor vizualizációját javítják. A közleményünkben az utóbbi technikák közül a legelterjedtebbeket tárgyaljuk, kiemelve a szűkített hullámhosszú képalkotás (narrow band imaging -NBI) jelentőségét. Betegek és módszer: Összesen 26 beteget vizsgáltak retrospektíve (nő: 10 -férfi: 16). Az endoszkópos vizsgálatok során Olympus cég Visera Elite (C-190) típusú speciális szűrők-kel ellátott fényforrásával először fehér fénnyel, hagyományos cisztoszkópiát végeztek, majd az NBI-technikát alkalmazták. Eredmények: Az NBI-vel történő vizsgálat során két betegnél észleltek olyan eltérést, amely fehér fénnyel nem volt detektálható. Megbeszélés: A szerzők hangsúlyozzák, hogy az eredmé-nyeket ezen új technikák kombinálása tovább javíthatja. KULCSSZAVAK NEM IZOMINVAZÍV HÓLYAGDAGANAT, RECIDÍVA, SZŰKÍTETT HULLÁMHOSSZÚ KÉPALKOTÁS (NBI)Promising imaging technique for diagno sing non-muscle invasive bladder tumour: NBI (narrow band imaging) in urology SUMMARY Objective: A high percentage of recurrent tumours can be obtained during the follow up of non-muscle invasive bladder tumours (NMIBT). In order to reduce this number, a lot of newly developed procedures have been introduced in the clinical practice. These are either biomarkers, and have a role in the follow up, or make the visualisation of bladder tumors more accurate. In the following article we discuss the most common methods and emphasize more importance to Narrow Band Imaging (NBI). Patients and method: A total of 26 patients were retrospectively examined (female: 10 -male: 16). The light source of Olympus's Visera Elite (C-190) type with special filters was used for endoscopic examinations. Conventional cystoscopy white light was performed, followed by NBI technique procedure. Results: Atipical malformations were detected in two cases during NBI examination that was not detectable with white light cystoscopy.

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A Randomized Prospective Trial to Assess the Impact of Transurethral Resection in Narrow Band Imaging Modality on Non–Muscle-Invasive Bladder Cancer Recurrence

Cited by 107 publications

References 18 publications

Advantage of transurethral resection with narrow band imaging for non-muscle invasive bladder cancer

Advantage of transurethral resection with narrow band imaging for non-muscle invasive bladder cancer

Approaching the optimal transurethral resection of a bladder tumor

Ígéretes képalkotó technika nem-izominvazív hólyagdaganatok diagnosztikájában: az NBI (narro band imaging) alkalmazása az urológiában

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