A Randomized Prospective Clinical Trial Comparing Laser SubepithelialKeratomileusis and Photorefractive Keratectomy

Pirouzian, Amir

doi:10.1001/archopht.122.1.11

Cited by 49 publications

(6 citation statements)

References 14 publications

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“…Pirouzian and colleagues14 concluded from their clinical trial comparing LASEK and PRK that patient satisfaction with postoperative visual acuity was equal between PRK and LASEK at 30 days postoperatively. However, they14 received contrasting perceptions from patients regarding the duration of the procedure and usage of an epithelial scrubber.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…However, they14 received contrasting perceptions from patients regarding the duration of the procedure and usage of an epithelial scrubber. About half of their14 patients preferred PRK over LASEK because of the faster surgical time. Alternately, the other half of patients preferred LASEK because they did not prefer the use an epithelial scrubber during the PRK procedure 14…”

Section: Discussionmentioning

confidence: 99%

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Efficacy, predictability, and safety of laser-assisted subepithelial keratectomy for the treatment of myopia and myopic astigmatism

Al-Tobaigy

2012

Middle East Afr J Ophthalmol

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Purpose:The purpose was to report the refractive and visual outcomes of laser-assisted subepithelial keratectomy (LASEK) for the treatment of myopia.Materials and Methods:A retrospective, noncomparative consecutive case series of 173 of 91 patients who had undergone LASEK is presented. Primary outcome variables included uncorrected visual acuity (UCVA), best spectacle-corrected visual acuity (BSCVA), manifest refraction, epithelialization time, pain, haze, and complications.Results:Preoperatively, the mean spherical equivalent (SE) was –3.71 ± 1.63 D (range, –0.875 D to 8.25 D), and the mean LogMAR BSCVA was –0.0374 ± 0.0767 D (range, –0.47 D to 0.00 D). On the final visit, the mean SE was –0.05 ± 0.335 D (range, –1.63 D to 1.00 D), the mean LogMAR UCVA was 0.04674 ± 0.0771 D (range, –0.3010 D to 0.1249 D) and the mean LogMAR BSCVA was –0.0164 ± 0.0497 (range –0.3010 to 0.124). All eyes achieved vision of 20/40 or better, and 83.2% of the eyes achieved a vision of 20/25 or better. One 64 (94.94%) and all the eyes were within ± 0.50 D and ± 1.00 D of the attempted correction respectively. Complete epithelialization occurred in 4.70 ± 2.09 days (range, 2-10 days). At the final visit, 79.7% of eyes had a clear cornea. Grade 1 haze developed in 17.34% of the eyes, grade 2 haze developed in 2.89% of eyes developed; no eyes developed grade 3 or 4 haze.Conclusions:LASEK is a safe, effective, and predictable method for the treatment of myopia and myopic astigmatism.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Efficacy, predictability, and safety of laser-assisted subepithelial keratectomy for the treatment of myopia and myopic astigmatism

Al-Tobaigy

2012

Middle East Afr J Ophthalmol

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“…Furthermore, the inactivated epithelium tissues will become a barrier for the epithelium to generate and migrate, which may aggravate the stimulation symptoms in the flap-preserved group, including post-operative ophthalmalgia and delay corneal epithelium recovery [3,4].…”

Section: Discussionmentioning

confidence: 99%

Flap Removal or Flap Preservation During LASEK Surgery

Liu

2010

Cell Biochem Biophys

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The objective of this study was to evaluate the effectiveness of corneal epithelial flap removal or flap preservation during LASEK operation on myopia and to determine whether there was any accrual of benefit in either approach. From March 2006 to March 2008, some 582 patients (1,164 eyes) who presented with myopia and myopic astigmatism were treated with corrective LASEK operations. They were divided into two groups: one group underwent corneal flap-preservation while the other had the corneal flap removed. Each group comprised 582 eyes, and the data accumulated were retrospectively analyzed. Each patient was examined after 1, 3, 5, and 7 days; 2 weeks; and 1, 2, 3, 6, and 12 months after LASEK surgery to determine their post-operative visual acuity and check for complications. All eyes achieved pre-operative corrected vision 16 weeks after LASEK surgery, with no difference being observed between the two groups. However, there was a significant difference in the ophthalmalgia observed 3 days after LASEK surgery, with the flap-removal group experiencing less post-operative pain than those who had the corneal flap preserved. Furthermore, by 3 days post-operation, the observed corneal epithelial healing was significantly different: again the eyes of those who had the corneal flap removed having a faster recovery than those belonging to the corneal preservation group. In conclusion, the patients who had a flap-removal LASEK operation recorded faster recovery and suffered less ophthalmalgia, but there was no significant difference in the overall outcome in terms of post-operative optimally corrected vision or complications such as haze formation.

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“…However, the mechanism of action and possible toxicity of this drug remain subjects of intense debate. Therefore, there is controversy about the outcomes of LASEK [12]- [14].…”

Section: Introductionmentioning

confidence: 99%

Re-Evaluation of the Safety of Laser-Assisted Subepithelial Keratectomy

Kumano¹,

Soejima²,

Numa³

et al. 2014

OJOph

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Purpose: Additional analyses of outcomes of laser-assisted subepithelial keratectomy (LASEK) are still necessary to improve the safety of LASEK. Therefore, in our study, outcomes were assessed retrospectively in 561 eyes that underwent LASEK treatment. Methods: Uncorrected visual acuity (UCVA), best spectacle-corrected visual acuity (BSCVA) and residual spherical equivalent were analyzed at 3 and 6 months postoperatively. We assessed four subgroups based on the degree of preoperative myopia considering mean BSCVA and loss of two or more lines. Results: Mean UCVAs and BSCVAs were obtained at 3 and 6 months postoperatively (1.23/1.35 and 1.23/1.37, respectively). The mean predictability was within ±0.125 diopters. Conversely, the safety indexes were 0.94 and 0.96 respectively, and the efficacy indexes were 0.86 and 0.86 at 3 and 6 months postoperatively, respectively. 8.4% eyes and 5.2% eyes lost two or more lines of BSCVA at 3 and 6 months postoperatively, respectively. The mean BSCVAs of the high or ultra-high groups were significantly lower than those of the low or mild groups both 3 months and 6 months postoperatively. The incidence rates of losing two or more lines of BSCVA in the high or ultra-high myopia groups were significantly greater than in the low or mild groups at 3 months and 6 months postoperatively. Conclusion: LASEK predictably corrected myopia achieving >1.2 in UCVA and BSCVA. However, the safety and efficacy indexes were <1.0, which were related to the loss of two or more lines of BSCVA. Since the incidence rates of losing two or more lines of BSCVA were greater in the high or ultra-high myopia groups, we consider LASEK as more safely performed in patients with low to mild preoperative myopia.

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A Randomized Prospective Clinical Trial Comparing Laser SubepithelialKeratomileusis and Photorefractive Keratectomy

Abstract: To compare laser subepithelial keratomileusis (LASEK) and photorefractive keratectomy (PRK) in different eyes of the same subjects for subjective pain level, visual acuity, and corneal epithelial healing.

Cited by 49 publications

References 14 publications

Efficacy, predictability, and safety of laser-assisted subepithelial keratectomy for the treatment of myopia and myopic astigmatism

Efficacy, predictability, and safety of laser-assisted subepithelial keratectomy for the treatment of myopia and myopic astigmatism

Flap Removal or Flap Preservation During LASEK Surgery

Re-Evaluation of the Safety of Laser-Assisted Subepithelial Keratectomy

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