A Randomized, Placebo-controlled Trial of Acetaminophen Extended Release for Treatment of Post-marathon Muscle Soreness

Prior, Mary Jane; Lavins, Bernhard J; Cooper, Kevin

doi:10.1097/ajp.0b013e318227cc4f

Cited by 12 publications

(6 citation statements)

References 18 publications

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“…We know of only one study to use such a strategy; they tested the efficacy of acetaminophen on muscle soreness post marathon running and successfully recruited over 600 participants [83].…”

Section: Recruiting People With Muscle Painmentioning

confidence: 99%

Methods for studying naturally occurring human pain and their analogues

Moore

Keogh

Crombez

et al. 2013

Pain

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Methods for investigating human pain have been developed over the last 100 years.Typically researchers focus on people with clinical pain, or on healthy participants undergoing laboratory controlled pain-induction techniques focussed mostly on exogenously generated skin nociception. Less commonly investigated are acute pain experiences that emerge naturally. Six common painful complaints were identified: headache, muscular pain, visceral pain, menstrual pain, dental pain, and pain associated with Upper Respiratory Tract Infection. Methods used to recruit participants with the natural occurrence of each pain complaint were identified, and features of their use reviewed. Also reviewed were experimental analogues designed to mimic these pains, with the exception of menstrual pain. Headache and menstrual pain appear to be most effectively researched in their naturally occurring form, whereas muscle and dental pain may be more easily induced. URTI and abdominal pain provide further challenges for researchers. Summary guidance is offered, and directions for methods development outlined.

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“…We know of only one study to use such a strategy; they tested the efficacy of acetaminophen on muscle soreness post marathon running and successfully recruited over 600 participants [83].…”

Section: Recruiting People With Muscle Painmentioning

confidence: 99%

Methods for studying naturally occurring human pain and their analogues

Moore

Keogh

Crombez

et al. 2013

Pain

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“…In addition to the beneficial effect of acetaminophen on relieving muscle soreness and pain (Prior et al, 2011), recent studies have suggested that acetaminophen can improve aged skeletal muscle structure and function (sarcopenia). Wu et al (2009b) firstly reported that chronic acetaminophen treatment at 30 mg/kg body weight is able to decrease the amount of aging-associated myocyte apoptosis and increase myocyte size (muscle fiber cross sectional area), with this latter effect occurring most likely associated with an increase in myosin and actin expression in aged muscle.…”

Section: Chronic Acetaminophen Ingestion Can Improve Blood Glucose Comentioning

confidence: 99%

Acetaminophen: Beyond Pain and Fever-Relieving

Blough¹,

Wu²

2011

Front. Pharmacol.

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Acetaminophen, also known as APAP or paracetamol, is one of the most widely used analgesics (pain reliever) and antipyretics (fever reducer). According to the U.S. Food and Drug Administration, currently there are 235 approved prescription and over-the-counter drug products containing acetaminophen as an active ingredient. When used as directed, acetaminophen is very safe and effective; however when taken in excess or ingested with alcohol hepatotoxicity and irreversible liver damage can arise. In addition to well known use pain relief and fever reduction, recent laboratory and pre-clinical studies have demonstrated that acetaminophen may also have beneficial effects on blood glucose levels, skeletal muscle function, and potential use as cardioprotective and neuroprotective agents. Extensive laboratory and pre-clinical studies have revealed that these off-label applications may be derived from the ability of acetaminophen to function as an antioxidant. Herein, we will highlight these novel applications of acetaminophen, and attempt, where possible, to highlight how these findings may lead to new directions of inquiry and clinical relevance of other disorders.

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“…The pharmacokinetics of paracetamol do not appear to be modified by exercise (ie, plasma concentration, clearance, and half‐life) and do not change during exercise compared with rest [25]. Paracetamol intake has not been associated with serious adverse events among most users [11], although some frequently reported mild‐to‐moderate side effects of short‐term administration within the therapeutic dose (maximum of 3 g daily) include nausea, vomiting, diarrhea, and abdominal pain. Liver failure has been reported after an overdose of paracetamol (>10 g) [26].…”

Section: Resultsmentioning

confidence: 99%

“…Therefore, in contrast to the postexercise use of analgesics to accelerate recovery, there is potential for their prophylactic use as a potential performance‐enhancing intervention. In comparison with what is known about the use of analgesics for treating sporting injury [10,11], much less is known about their effects on exercise‐related physiology and performance [12‐14]. However, because analgesics exert a pharmacologic action on key physiological systems related to exercise performance, a theoretical rationale exists whereby these drugs could provide a significant ergogenic effect.…”

Section: Introductionmentioning

confidence: 99%

Analgesics and Sport Performance: Beyond the Pain‐Modulating Effects

Holgado

Hopker

Sanabria

et al. 2017

PM&R

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1Analgesics are widely used in sport to treat pain and inflammation associated with injury. However, there 2 is growing evidence that some athletes might be taking these substances in an attempt to enhance Introduction 18There is little doubt that when exercise is performed above certain intensities, or over a prolonged period 19 of time, it causes feeling of pain and discomfort. Sayings such as 'no pain, no gain' are often heard in 20 relation to both training and competition settings across a variety of different sports. Indeed, these 21 feelings of exercise-induced pain have been shown to have a negative effect on training and performance 22 [1]. As a consequence, there has been a trend for athletes from all levels and ages to use pharmacological 23 analgesics substances prior to training and competition up to 4-fold more than their age-matched general 24 population [2]. The general term analgesic covers a variety of different pharmacological substances, 25 including non-steroidal anti-inflammatory drugs (NSAIDs), non-opioid analgesic (such as paracetamol 26 2 and others), weak opioids (for example tramadol, codeine or morphine [3]) and orally administered or 27 injected glucorticosteroids [4,5]. Indeed, paracetamol and NSAIDs are one of the most recurrent groups 28 of pharmacological substances used by athletes ranging from 11 up to 92% [6,7]. For instance, it is 29 common for athletes with minor injuries to continue training and even competing, by treating their minor 30 health issues with analgesic [8]. 31The aforementioned negative association between pain and exercise capacity increases the likelihood of 32 analgesic use as a method to increase the level of performance during competition [5,9]. Furthermore, the 33 trends for more frequent use of analgesics in-competition vs. out-competition, use of more than one drug 34 at the same time, and administration of these medications at supratherapeutic dosages, all suggest athletes 35 may be using these analgesics as ergogenic aids [4,5]. Therefore, in contrast to the post-exercise use of 36 analgesics to accelerate recovery, there is potential for their prophylactic use as a potential performance 37 enhancing intervention. In comparison to what is known about the use of analgesics for treating sporting 38 injury [10,11], much less is known about their effects on exercise related physiology and performance 39 [12][13][14]. However, as analgesics exert a pharmacological action on key physiological systems related to 40 exercise performance, a theoretical rationale exists whereby these drugs could provide a significant 41 ergogenic effect. 42 Material and methods 43The aim of this manuscript was to review the literature and evaluate the evidence for the ergogenic effect 44 of analgesics, expected dosages, and potential side effects. A computer search of scientific databases 45 (PubMed, Web of Science, ScienceDirect and Scopus) was made for English language articles 46 investigating the use of analgesics in sport for all period of time up to September 2...

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A Randomized, Placebo-controlled Trial of Acetaminophen Extended Release for Treatment of Post-marathon Muscle Soreness

Abstract: Acetaminophen ER 1300 mg, a nonprescription drug, was an effective treatment for post-race muscle soreness on the day of the marathon. In addition, acetaminophen ER provided benefit for interference with sleep and overall satisfaction with treatment, and was generally well tolerated.

Cited by 12 publications

References 18 publications

Methods for studying naturally occurring human pain and their analogues

Methods for studying naturally occurring human pain and their analogues

Acetaminophen: Beyond Pain and Fever-Relieving

Analgesics and Sport Performance: Beyond the Pain‐Modulating Effects

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