A Randomized Pilot Study of Stochastic Vibration Therapy in Spinocerebellar Ataxia

Kaut, Oliver; Jacobi, Heike; Coch, Christoph; Prochnicki, A.; Minnerop, Martina; Klockgether, Thomas; Wüllner, Ullrich

doi:10.1007/s12311-013-0532-5

Cited by 31 publications

(45 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Historically, in line with the classical view of the CB as a motor center, the main focus of rehabilitation approaches has been on motor aspects, mainly ataxia and dysmetria [135,136], although there is limited evidence about their effectiveness [137][138][139][140].…”

Section: Introducing Cognition Into Cerebellarmentioning

confidence: 99%

The Cerebellar Cognitive Affective/Schmahmann Syndrome: a Task Force Paper

et al. 2019

View full text Add to dashboard Cite

Sporadically advocated over the last two centuries, a cerebellar role in cognition and affect has been rigorously established in the past few decades. In the clinical domain, such progress is epitomized by the "cerebellar cognitive affective syndrome" ("CCAS") or "Schmahmann syndrome." Introduced in the late 1990s, CCAS reflects a constellation of cerebellar-induced sequelae, comprising deficits in executive function, visuospatial cognition, emotion-affect, and language, over and above speech. The CCAS thus offers excellent grounds to investigate the functional topography of the cerebellum, and, ultimately, illustrate the precise mechanisms by which the cerebellum modulates cognition and affect. The primary objective of this task force paper is thus to stimulate further research in this area. After providing an up-to-date overview of the fundamental findings on cerebellar neurocognition, the paper substantiates the concept of CCAS with recent evidence from different scientific angles, promotes awareness of the CCAS as a clinical entity, and examines our current insight into the therapeutic options available. The paper finally identifies topics of divergence and outstanding questions for further research.

show abstract

Section: Introducing Cognition Into Cerebellarmentioning

confidence: 99%

The Cerebellar Cognitive Affective/Schmahmann Syndrome: a Task Force Paper

et al. 2019

View full text Add to dashboard Cite

show abstract

“…Therapeutic approaches vary, 4 but they typically fail to sufficiently alleviate symptoms. [5][6][7][8][9] Most degenerative ataxias feature Purkinje cell loss, 10,11 resulting in modified inputs to the deep cerebellar nuclei; thus, neuromodulation targeting these deep cerebellar nuclei may succeed in numerous DCAs.…”

mentioning

confidence: 99%

Deep cerebellar stimulation reduces ataxic motor symptoms in the shaker rat

Anderson¹,

Figueroa²,

Dorval

et al. 2019

Annals of Neurology

View full text Add to dashboard Cite

Objective: Degenerative cerebellar ataxias (DCAs) affect up to 1 in 5,000 people worldwide, leading to incoordination, tremor, and falls. Loss of Purkinje cells, nearly universal across DCAs, dysregulates the dentatothalamocortical network. To address the paucity of treatment strategies, we developed an electrical stimulation-based therapy for DCAs targeting the dorsal dentate nucleus. Methods: We tested this therapeutic strategy in the Wistar Furth shaker rat model of Purkinje cell loss resulting in tremor and ataxia. We implanted shaker rats with stimulating electrodes targeted to the dorsal dentate nucleus and tested a spectrum of frequencies ranging from 4 to 180 Hz. Results: Stimulation at 30 Hz most effectively reduced motor symptoms. Stimulation frequencies >100 Hz, commonly used for parkinsonism and essential tremor, worsened incoordination, and frequencies within the tremor physiologic range may worsen tremor. Interpretation: Low-frequency deep cerebellar stimulation may provide a novel strategy for treating motor symptoms of degenerative cerebellar ataxias.

show abstract

“…Positive effects were later observed in Parkinson's disease (PD) (5). We recently confirmed an improvement in core motor symptoms, such as bradykinesia and postural stability in PD (6), and provided evidence of improved gait and speech in spinocerebellar ataxias (SCA; 1, 2, 3, 6) after treatment with stochastic resonance therapy (7).…”

Section: Introductionmentioning

confidence: 65%