A randomized, open phase IV exploratory clinical trial to evaluate the efficacy and safety of acupuncture on the outcome of induction of ovulation in women with poor ovarian response

Abstract

Introduction:Women with infertility who have a poor ovarian responder (POR), characterized by a low number of retrieved oocytes after ovulation induction, often have a significantly reduced pregnancy rate after in vitro fertilization-embryo transfer (IVF-ET), due to the few transferred embryos. Acupuncture is a form of Korean Traditional Medicine. It involves the insertion of a microscopic needle at a specific point in the body, known as an acupuncture point or an acupoint. In this study, our purpose is to investigate how acupuncture affects the retrieval of mature oocytes after ovulation induction in patients with POR.Methods and analysis:This study will be a randomized clinical trial comprising an IVF-ET trial and an IVF-ET trial after acupuncture. Seventy patients will by enrolled and randomly assigned to either of the 2 groups. The study subjects will be required to be diagnosed as having POR. Participants will be divided into 2 groups: IVF-ET single treatment group, and acupuncture and IVF-ET combined treatment group. The study subjects will be required to participate in a 15-week trial involving 16 acupuncture treatments over a period of approximately 2 months before ovulation induction for oocyte retrieval. The primary assessment of all participants will be comparing the number of oocytes.Result:This treatment will be a therapeutic model for POR.Discussion:Our results will provide patients with POR as well as complementary and alternative medicine professionals, such as Korean medicine doctors, about the potential role of acupuncture in the treatment of POR. This will improve the quality of life in women with infertility and provide an important treatment option for patients with POR. Further studies can be performed to determine the optimal treatment for POR.

Effect of acupuncture on women with poor ovarian response: study protocol for a multicenter randomized controlled trial

“…This trial is the second study using acupuncture treating POR. Compared with the published POR research [25], this trial will use the same control (non-treatment) and primary outcome (the number of retrieved oocytes), but different acupuncture protocol and more secondary outcomes to better assess the acupuncture effect for POR. In this trial, non-treatment rather than placebo will be used as control due to the following reasons: placebo acupuncture is di cult to implement [26], and women are usually suggested to rest for 2-3 months between the two IVF cycles in clinical practice.…”

Effect of acupuncture on women with poor ovarian response: a study protocol for a multicenter randomized controlled trial

“…However, the study population of these trials generally did not focus on women with POR. To date, there is only one study (a protocol published in 2018) [25] that aimed to assess the effect of acupuncture for POR. The present trial will be the second study using acupuncture treating POR.…”

“…The present trial will be the second study using acupuncture treating POR. Compared with the published POR research [25], this trial will use the same control (nontreatment) and primary outcome (the number of retrieved oocytes), but a different acupuncture protocol and more secondary outcomes to better assess the acupuncture effect for POR. In this trial, nontreatment rather than placebo will be used as control due to the following reasons: placebo acupuncture is difficult to implement [26], and women are usually suggested to rest for 2-3 months between the two IVF cycles in clinical practice.…”

Effect of acupuncture on women with poor ovarian response: study protocol for a multicenter randomized controlled trial

“…However, the study population of these trials generally did not focus on women with POR. Up to date, there is only one literature (a study protocol published in 2018) [25] aiming to assess the effect of acupuncture for POR. This trial is the second study using acupuncture for treating POR.…”

“…This trial is the second study using acupuncture for treating POR. Compared with the published POR research [25], this trial will use the same control (non-treatment) and primary outcome (the number of retrieved oocytes), but different acupuncture protocol and more secondary outcomes to better assess the acupuncture effect for POR. In this trial, non-treatment rather than placebo will be used as control due to the following reasons: placebo acupuncture is difficult to implement [26], and women are usually suggested to rest for 2-3 months between the two IVF cycles in clinical practice.…”