A randomized, open, parallel-group study on the preventive effect of an estradiol-releasing vaginal ring (Estring) on recurrent urinary tract infections in postmenopausal women

Eriksen, Bjarne C.

doi:10.1016/s0002-9378(99)70597-1

Cited by 297 publications

(115 citation statements)

References 14 publications

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“…However, there are barriers to acceptance of this therapy, especially in institutionalized women, since the intervention requires periodic administration of topical vaginal estrogen. An indwelling estradiol vaginal ring has also been shown to reduce recurrent UTI in postmenopausal women but may difficult to place and lead to local complications in some frail elderly women [31]. In incontinent elderly women in nursing homes, oral estrogen with progestin was effective in improving atrophic vaginitis but not in improving continence or reducing UTIs [32].…”

Section: Hormonalmentioning

confidence: 99%

Urinary tract infections in the frail elderly: Issues for diagnosis, treatment and prevention

Richards

2004

Int Urol Nephrol

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Urinary tract infections (UTIs) are among the most common infections in frail elderly adults, whether they are community dwelling, live in long term care facilities (LTCFs) or are hospitalized. UTIs cause substantial morbidity and mortality in frail elderly men and women. While many major risk factors in these individuals may not be modifiable, improved attention to incontinence management, judicious use of antimicrobials and urinary catheters, and, in women, appropriate use of topical estrogen may be useful in reducing UTIs. Future strategies may also include the appropriate use of new urinary catheter technology and emerging vaccines.

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Section: Hormonalmentioning

confidence: 99%

Urinary tract infections in the frail elderly: Issues for diagnosis, treatment and prevention

Richards

2004

Int Urol Nephrol

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“…Another RCT of 108 women randomly assigned to receive either the controlled-release estradiol vaginal ring or placebo showed a relative reduction of 0.64 infections per year in the treatment arm relative to placebo (CI, 0.47-0.86) [34]. The estrogen group showed a higher number of women who remained infection-free (80% vs 51%).…”

Section: Estrogen For Recurrent Urinary Tract Infectionsmentioning

confidence: 99%

Does Estrogen Have Any Real Effect on Voiding Dysfunction in Women?

Koski

Chermansky

2011

Curr Urol Rep

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For many years, estrogen has been used to treat lower urinary tract dysfunction in postmenopausal women. The data supporting this practice vary. Large multi-institutional studies have shown little role for systemic estrogens in the treatment of urinary incontinence. Vaginal estrogen preparations show superiority to systemic estrogens for the treatment of irritative voiding symptoms in meta-analysis, but there is significant study heterogeneity and the practice remains debatable. Data from randomized controlled trials support estrogen use in the prevention of recurrent urinary tract infections. This article reviews the relevant literature addressing the role of estrogen therapy in urinary incontinence, irritative voiding symptoms, and recurrent urinary tract infections.

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“…Das Paraurethralgewebe als auch die Detrusormuskulatur rund um die Blase werden unter Östrogenmangel atrophisch [89,90]. HRT und intravaginale Estradiolapplikation sind in der Lage, die Häufigkeit aufsteigender Harnblaseninfekte zu reduzieren [6,92]. Östrogensensitiv sind ebenfalls die prä-synaptischen Ganglien der Harnblase [91], was auf eine mögliche nervale Komponente der Harninkontinenz hinweist.…”

Section: Knochenunclassified

Phytoöstrogene – eine Alternative zur Standardhormonersatztherapie?

et al. 2002

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Phytoestrogensan alternative to standard hormone replacement therapy? AbstractDue to some severe side effects,"classic"hormone replacement therapy (HRT) is currently being challenged by therapy with phytoestrogens.Particularly soy-and red cloverderived isoflavones are advertised as selective estrogen receptor modulators (SERMs) with only desired and no undesired estrogenic effects.Evidence that this is the case however is scarce.Most studies investigating climacteric complaints did not find beneficial effects.A proposed beneficial effect on mammary cancer is unproven.The majority of studies however indicate an antiosteoporotic effect of isoflavones, while putative beneficial effects in the cardiovascular system are questionable due to the fact that estradiol, which -like isoflavones -increases HDL and decreases LDL concentrations, does not appear to prevent arteriosclerosis in humans.In the urogenital tract, including the vagina, soy-and red clover-derived isoflavones exert no effects.Cimicifuga racemosa extracts are traditionally used for the treatment of climacteric complaints.Evidence is now available that the as yet unknown compounds in Cimicifuga racemosa extracts prevent climacteric complaints and may also have antiosteoporotic effects.

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A randomized, open, parallel-group study on the preventive effect of an estradiol-releasing vaginal ring (Estring) on recurrent urinary tract infections in postmenopausal women

Cited by 297 publications

References 14 publications

Urinary tract infections in the frail elderly: Issues for diagnosis, treatment and prevention

Urinary tract infections in the frail elderly: Issues for diagnosis, treatment and prevention

Does Estrogen Have Any Real Effect on Voiding Dysfunction in Women?

Phytoöstrogene – eine Alternative zur Standardhormonersatztherapie?

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