A Randomized Open‐Label Trial with a Crossover Comparison of Sexual Self‐Confidence and Other Treatment Outcomes Following Tadalafil Once a Day Vs. Tadalafil or Sildenafil On‐Demand in Men with Erectile Dysfunction

Rubio‐Aurioles, Eusebio; Porst, Hartmut; Kim, Edward D.; Montorsi, Francesco; Hackett, Geoff; Morales, Antonio Martín; Stuckey, Bronwyn; Büttner, H.; West, Teena; Huynh, Ngan; Lenero, Enrique; Burns, Patrick R.; Kopernicky, Vladimir

doi:10.1111/j.1743-6109.2012.02667.x

Cited by 31 publications

(45 citation statements)

References 21 publications

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“…67 In two randomized controlled trials, sexual self-confidence and perceived spontaneity were higher with daily-use or on-demand tadalafil than ondemand sildenafil. 68,69 Despite these possible advantages, prescribing daily use of PDE5I drugs needs to be weighed on a case-by-case basis against the fact that for many patients daily use of these drugs constitutes considerable financial burden and contributes to treatment discontinuance. 18 Another possible penile rehabilitation strategy is to recommend masturbation, as blood flow is stimulated even if the penis remains flaccid.…”

Section: Consider Prehabilitationmentioning

confidence: 99%

Psychosocial perspectives on sexual recovery after prostate cancer treatment

Walker¹,

Wassersug

Robinson³

2015

Nat Rev Urol

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Many therapies for erectile dysfunction (ED) after prostate cancer treatment improve erectile firmness, yet, most couples stop using aids within 1-2 years. Patients and partners who expect immediate and complete success with their first ED treatment can be demoralized when they experience treatment failure, which contributes to reticence to explore other ED aids. Comprehensive patient education should improve sustainability and satisfaction with ED treatments. Pre-emptive and realistic information should be provided to couples about the probability of recovering natural erections. Beginning intervention early and using a couple-based approach is ideal. Recommendations are provided about the timing of ED treatment, the order of aid introduction, and combination therapies. Renegotiation of sexual activity is an essential part of sexual adaptation. From the outset of therapy, couples should be encouraged to broaden their sexual repertoire, incorporate erection-independent sexual activities, and continue to be sexual despite ED and reduced libido.

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Section: Consider Prehabilitationmentioning

confidence: 99%

Psychosocial perspectives on sexual recovery after prostate cancer treatment

Walker¹,

Wassersug

Robinson³

2015

Nat Rev Urol

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“…Recent evidence indicates that ED men may prefer daily use of PDE5I to on-demand use, due to greater improvements in sexual self-confidence, time concerns, and spontaneity 86. The on-demand use of PDE5I requires scheduled sexual activities, which may not be favored either by ED men or their sexual partners.…”

Section: Discussionmentioning

confidence: 99%

Udenafil for the treatment of erectile dysfunction

Cho¹,

Paick²

2014

TCRM

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Erectile dysfunction (ED) is often perceived by both patients and sexual partners as a serious problem that can jeopardize quality of life, psychosocial or emotional well-being, and the partnership in the long term. Since their introduction, oral phosphodiesterase type 5 inhibitors (PDE5Is) have been found to be highly effective and well tolerated, and are available as the first-line therapy for the treatment of ED. Udenafil is one of the selective PDE5Is made available in recent years for the treatment of ED. Udenafil has clinical properties of both relatively rapid onset and long duration of action due to its pharmacokinetic profile, thereby providing an additional treatment option for ED men to better suit individual needs. There is positive evidence that udenafil is effective and well tolerated in the treatment of ED of a broad spectrum of etiologies or severity. Udenafil is as effective in the treatment of diabetes mellitus-associated ED as other PDE5Is. Due to the clinical property of relatively long duration of action, udenafil may be another option in daily dosing treatment for ED, as suggested by its favorable efficacy and safety profile. Most adverse effects reported from clinical trials are mild or moderate in severity, without any serious adverse event, with headache and flushing being the most common. Also, the concomitant use of anti-hypertensive drugs or alpha-1-blockers does not significantly affect the efficacy and safety profile of udenafil. However, additional studies with larger cohorts including prospective, multicenter, comparative studies with patients of different ethnicities are needed to further validate the favorable findings of udenafil in the treatment of ED.

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“…This approach ignored the fact that the same patient appeared twice in the study, which gave rise to a unit-of-analysis error. (3) Two studies [10,13] did not report SEP-2. One study [13] did not report SEP-3.…”

Section: Discussionmentioning

confidence: 99%

“…(3) Two studies [10,13] did not report SEP-2. One study [13] did not report SEP-3. Standard error of SEP-2 of one study [11] could not be obtained.…”

Section: Discussionmentioning

confidence: 99%

“…Based on these considerations, psychosocial outcomes appear to be associated with the dosing regimen of tadalafil. In studies conducted by Rubio-Aurioles et al [13] and Hatzimouratidis et al [18] , Psychological and Interpersonal Relationship Scales were evaluated specifically, including sexual self-confidence, spontaneity, and time concerns. Both studies found that tadalafil once-a-day was superior to tadalafil on-demand with statistical significance in the time concerns domain.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Efficacy and Safety of Tadalafil Once-a-Day versus Tadalafil On-Demand in Patients with Erectile Dysfunction: A Systematic Review and Meta-Analyses

et al. 2017

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Introduction: To compare the efficacy and safety between tadalafil once-a-day and tadalafil on-demand dosing regimen in patients with ED. Materials and Methods: A systematic search of Medline, Embase, and Cochrane Library was performed to identify all randomized controlled trials (RCTs) that compared tadalafil used a once-a-day with an on-demand dosing regimen for erectile dysfunction. A secondary hand-search was performed in relevant journals, references, and the grey literature. Meta-analyses were performed using Review Manager version 5.3.0. Results: Six RCTs involving a total of 1,534 patients were included in this review. All studies reported the International Index of Erectile Function-Erectile Function domain score and the results of the meta-analysis showed no difference between the groups. The overall pooled estimated weighted mean differences (WMD) was 0.97 (95% CI -0.37 to 2.32; p = 0.16). Meta-analyses of Sexual Encounter Profile questions 2 and 3 (SEP-2 and SEP-3) showed that the once-a-day dosing regimen was superior to the on-demand regimen with statistical significance. The WMD of SEP-2 and SEP-3 were 10.32 (95% CI 3.16-17.48; p = 0.005) and 11.07 (95% CI 2.57-19.56; p = 0.01), respectively. Both dosing regimens of tadalafil showed similar complication rates. The meta-analyses of adverse events showed no significant differences. Conclusions: The efficacy rates of tadalafil once-a-day and on-demand were similar. No significant difference in safety was found between the 2 dose regimens of tadalafil.

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A Randomized Open‐Label Trial with a Crossover Comparison of Sexual Self‐Confidence and Other Treatment Outcomes Following Tadalafil Once a Day Vs. Tadalafil or Sildenafil On‐Demand in Men with Erectile Dysfunction

Cited by 31 publications

References 21 publications

Psychosocial perspectives on sexual recovery after prostate cancer treatment

Psychosocial perspectives on sexual recovery after prostate cancer treatment

Udenafil for the treatment of erectile dysfunction

Efficacy and Safety of Tadalafil Once-a-Day versus Tadalafil On-Demand in Patients with Erectile Dysfunction: A Systematic Review and Meta-Analyses

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