A randomized, open-label, comparative, crossover trial on preference, efficacy, and safety profiles of lispro insulin u-100 versus concentrated lispro insulin u-200 in patients with type 2 diabetes mellitus: a possible contribution to greater treatment adherence

Abstract

Checking for LJIMS before insulin prescription could be adopted as a standard practiceaimed at choosing the most suitable device for patient's specific characteristics and abilities. The use of U-200 lispro might improve treatment adherence and metabolic control. This would also result intocost reduction by saving about half the amount of pens per year and of time spent to both fill prescriptionand dump the pharmacy.

Patient Preferences and Health State Utilities Associated with Mealtime Insulin Concentrations Among Patients with Diabetes in Italy

“…Findings from this Italian sample provide insight into patient preferences associated with rapid-acting insulin concentration. Results are consistent with those from previous studies showing a preference for concentrated over standard insulin [33,35]. The findings of the current study add to previous research by demonstrating the strength of this preference, while providing utility values that can represent patient preference in cost-effectiveness analyses comparing insulin formulations.…”

“…A literature search was conducted to support health state content and guide subsequent discussions with clinicians. The literature search focused on standard (100 units/mL) and concentrated (200 units/mL) insulin lispro product information [18], glide force (i.e., the amount of effort required to press the pen's injection button) [31], and patient perceptions of standard and concentrated insulin [32][33][34][35].…”

Therapy of Type 2 Diabetes

“…Compared to insulin lispro 100, insulin lispro 200 showed also significant improvements in variability of fasting glucose, HbA1c, hypoglycemic rate and satisfaction with therapy. At the same time, 20 % insulin could be saved [143].…”

Therapie des Typ-2-Diabetes

“…Im Vergleich zu Insulin lispro 100 zeigte Insulin lispro 200 signifikante Verbesserungen der Variabilität der Nüchternglukose, des HbA 1c , der Hypoglykämie-Rate und der Zufriedenheit mit der Therapie. Gleichzeitig konnten 20 % Insulin eingespart werden [143].…”