A randomized multicenter clinical evaluation of sequential application of 0.3% and 0.15% hyaluronic acid for treatment of dry eye

Jun, Jong Hwa; Bang, Seung Pil; Park, Han Sang; Yoon, D. H.; Ahn, Ja Young; Kim, Seong Jae; Kim, Hong Kyun

doi:10.1007/s10384-021-00885-x

Cited by 6 publications

(10 citation statements)

References 34 publications

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“…Artificial tear drops are widely used among both healthy individuals and in DED patients (Table 1). 9–33 New products, in the form of osmoprotectants, lipid-based formulations, hyaluronic acid preparations/combinations, and multicomponent AT preparations, have emerged into the market. Despite a number of new studies comparing different AT formulations, it is hard to make comparisons between preparations because of variable patient populations tested and variable endpoints.…”

Section: Resultsmentioning

confidence: 99%

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Update on Dry Eye Disease Treatment: Evidence From Randomized Controlled Trials

Ucakhan,

Celik-Buyuktepe,

Yang

et al. 2023

Eye &Amp; Contact Lens: Science &Amp; Clinical Practice

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Although the ultimate goal of dry eye disease (DED) management is to restore the ocular surface and tear film homeostasis and address any accompanying symptoms, addressing this is not an easy task. Despite the wide range of current treatment modalities targeting multiple aspects of DED, the available DED management literature is quite heterogeneous, rendering evaluation or comparison of treatment outcomes hard or almost impossible. There is still a shortage of well-designed, large-scale, nonsponsored, randomized, controlled trials (RCTs) evaluating long-term safety and efficacy of many targeted therapies individually or used in combination, in the treatment of identified subgroups of patients with DED. This review focuses on the treatment modalities in DED management and aims to reveal the current evidence available as deduced from the outcomes of RCTs.

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Section: Resultsmentioning

confidence: 99%

“…Currently, there seems to be no evidence of superiority of a particular AT formulation over another or better efficacy of any multicomponent AT formulation over a basic one-component AT formulation in a particular subset of patients with DED (Table 1). 9–33…”

Section: Resultsmentioning

confidence: 99%

Update on Dry Eye Disease Treatment: Evidence From Randomized Controlled Trials

Ucakhan,

Celik-Buyuktepe,

Yang

et al. 2023

Eye &Amp; Contact Lens: Science &Amp; Clinical Practice

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“…The Arabic version of the OSDI questionnaire consists of 12 domains and was used to evaluate the dry eye symptoms. Arab-OSDI scores were divided into normal (0-12), mild (13)(14)(15)(16)(17)(18)(19)(20)(21)(22), moderate (23)(24)(25)(26)(27)(28)(29)(30)(31)(32), and severe symptoms (33-100) [16]. Assessment clinical diagnostic tests of DED was carried out including TMH, MGDs, ML staining, conjunctival staining, STT II, BUT, and the CFS.…”

Section: Methodsmentioning

confidence: 99%

“…ocular comfort [8]. However, there have been con icting ndings on the effectiveness of SH in treating dry eye symptoms, tear lm instability, inadequate aqueous tear secretion, and ocular surface staining [9][10][11][12][13].…”

mentioning

confidence: 99%

The Efficacy of Ocular Lubricants With 0.38% SH Gelling Ingredient and 0.18% SH Non-gelling Ingredient in Treating Dry Eye in Adult Gazan Participants

Aljarousha,

Badarudin,

Azemin

et al. 2023

Preprint

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Purpose: This study aimed to assess the efficacy of two formulations of lubricant eye drops, containing a gelling agent or not, compared to normal saline. Study Design: This was a prospective, randomized, double-blinded, three-group, parallel, interventional single-site clinical study. Methods: Forty-five Gazan participants with moderate to severe dry eye disease (DED) were randomized into three groups of 15 participants each. Each group received either normal saline eye drops or lubricant eye drops. For each group, one drop was applied three times a day for six weeks. All participants applied the normal saline solution for the first week. The outcomes assessed were the Arab-ocular surface disease index (OSDI) scores and clinical tests including tear break-up time test (TBUT), corneal fluorescein staining (CFS), and lissamine green conjunctival staining (LGS) at weeks 1, 3, and 6. Results: Both formulations exhibited a significant improvement in Arab-OSDI scores from visit 2 at follow-up time points (p < 0.001). TBUT, CFS, and LGS showed an improvement in both the 0.15% SH and 0.38% SH groups (p < 0.05). SH 0.38% had a greater improvement in the proportion of evaporative dry eye from visit 2 to visit 5 (p = 0.001). Conclusion: Lubricant eye drops are beneficial for alleviating the symptoms of dry eye. There was no noticeable difference in the effectiveness of these formulations in relieving symptoms and changing any of the objective signs that were assessed. Improved EDE outcomes occurred with SH 0.38% eye drops, observed between visit 2 and visit 5.

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“…The unique viscosity and high rheological affinity for natural fluids has rendered a high interest in cross-linked HA in a wide range of biomedical applications, such as destruction preventer and restoration initiator of cartilage during osteoarthritis [56] , [57] , eye drops for dry eye syndrome [58] , [59] , and dermal fillers [60] , [61] .…”

Section: Ha Applicationmentioning

confidence: 99%