A Randomized, Multi-Center, Clinical Trial to Assess the Efficacy and Safety of Alginate Carboxymethylcellulose Hyaluronic Acid Compared to Carboxymethylcellulose Hyaluronic Acid to Prevent Postoperative Intrauterine Adhesion

Kim, Tak; Ahn, Ki Hoon; Choi, Doo Seok; Hwang, Kyu Ri; Lee, Byoung Ick; Jung, Min Hyung; Kim, Jae Weon; Kim, Jong Hyuk; Hee, Sun; Lee, Ki Hwan; Lee, Kyu Sup; Oh, Se Jin; Cho, Chi Heum; Rhee, Jeong Ho

doi:10.1016/j.jmig.2012.08.003

Cited by 44 publications

(35 citation statements)

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“…effects of alginate, of which the two most commonly reported effects are its antimicrobial and hemostatic effects. 13) Na et al 14) hypothesized that the antimicrobial and hemostatic effects of alginate ultimately prevent tissue adhesion, and Kim et al 9) reported that alginate-combined HA/CMC injections are more effective at preventing adhesion formation after hysteroscopic surgery than alginate-lacking HA/CMC injections.…”

Section: Discussionmentioning

confidence: 99%

“…And this cuff region undergoing reparation becomes filled with and held together by Sharpey's fibers. 9,15) But postoperative pain may resolve even in situations where the repair of the rota- tor cuff was unsuccessful-that is independently of the action of Sharpey's fibers. Thus, it would be misleading to regard resolution of pain as the only parameter of successful cuff repairs, but other parameters such as restored normal tension in ligaments should also be evaluated.…”

Section: Discussionmentioning

confidence: 99%

“…8) The injection of the HA/CMC formulation as a post-adjunct to arthroscopic rotator repairs has been shown to be associated with a good recovery of range of motion (ROM) and good clinical outcomes in cuff tear patients with few postoperative complications. 9) Another adhesion barrier that has been developed is Protescal, which consists of HA and CMC, as in Guardix, but also sodium alginate. In this study, we made a comparative analysis of the clinical outcomes after using either anti-adhesive agent as adjunct therapy after arthroscopic rotator repair.…”

Section: Introductionmentioning

confidence: 99%

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Effectiveness of the Anti-adhesive Agent Protescal after Arthroscopic Rotator Cuff Repair: A Retrospective Study

Chung

Yoo

Jeong

2017

Clinics in Shoulder and Elbow

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Background: Many hyaluronic acid (HA)-based anti-adhesive agents have been commercialized for clinical use in the pharmaceutical market. But their efficacy in arthroscopic rotator cuff repairs remains elusive. To determine their efficacy, we performed a comparative analysis of the effects of two hyaluronate/carboxymethylcellulose (CMC)-based anti-adhesive agents, Protescal and Guardix. Methods: We recruited a total of 256 patients who had received an arthroscopic rotator cuff repair at our hospital between January 2014 and March 2015. Among them, 96 patients fulfilled the study's selection criteria and were enrolled as the final population sample. Thirty patients who had received a postoperative injection of Protescal were allocated into Group A. Another 30 patients who had received a postoperative injection of Guardix were allocated into Group B. As controls, 36 patients who did not receive any injection were allocated into Group C. The patients included in this study were aged between 19 and 75 years. For the clinical assessment, we measured the following clinical parameters-the visual analogue scale for pain (PVAS), the American Shoulder and Elbow Surgeons (ASES) score, and the constant score, as well as passive range of motions (ROMs)-at three time-points (preoperatively, 2-month postop eratively, and 6-month postoperatively). Results: We found that Group A compared to Group B tended to show a swifter recovery in passive anterior elevation and in internal rotation by the 2-month postoperative follow-up, but the differences were not statistically significant. Conclusions: We found that the effects of HA/CMC-based injections were minimal after arthroscopic rotator cuff repairs. (Clin Shoulder Elbow 2017;20(1):3-9)

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Effectiveness of the Anti-adhesive Agent Protescal after Arthroscopic Rotator Cuff Repair: A Retrospective Study

Chung

Yoo

Jeong

2017

Clinics in Shoulder and Elbow

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“…Средняя частота возникновения рецидива после оперативного лечения внутриматочных синехий составляет около 28 % [10]. Для про-филактики рецидива спаечного процесса в по-лость матки предлагают введение гелеобразных наполнителей (противоспаечных барьеров), препятствующих контакту стенок и образова-нию спаек [11][12][13]. Кроме того, имеются сооб-щения о применении циклической гормоноте-рапии, физиопроцедур, гидролизата плаценты человека, тромбоцитарного колониестимулиру-ющего фактора роста, эндометриальных мезен-химальных стволовых клеток в целях успешной регенерации эндометрия [7,[14][15][16][17].…”

Section: Introductionunclassified

Experience of application anti adgesivebarrier in the treatment of patients with Asherman’s syndrome

2016

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■ Relevance. Asherman's syndrome is one of the most difficult problems in gynecologic practice, because in addition to complex clinical picture, which includes secondary amenorrhea and infertility is a significant difficulty in diagnosis and treatment. The purpose was to improve the results of treatment of Аsherman's syndrome after conducting hysteroresectoscope adhesiolysis using anti adhesive barrier "Antiadgezin". Materials and methods. The study included 36 patients with peritoneal process in the uterus of varying severity. Group I consisted of 20 women who are in the postoperative period in the uterine cavity was entered "Antiadgezin", group II -16 women with similar pathology without introducing anti adgesive barriers. Results. All women 3 months after adhesiolysis was performed a control hysteroscopy. The presence of adhesions was diagnosed in 2 (10%) patients in the first group, while adhesions were isolated delicate and easily destroyed by the sheath of a hysteroscope. In group II adhesions had recurrences in 5 (31,3%) patients (p = 0,038), and one patient was visualized "tunnel" -uterus, which is extremely unfavorable course of disease. Conclusion. Treatment of Asherman's syndrome, as extreme degree of intrauterine adhesions, requires a comprehensive approach, which is based on prevention of recurrence of the formation of adhesions after surgical interventions. Research on application anti adgesivebarriers will continue, as intrauterine their use on the example of antiadgezin showed good results.■ Keywords: amenorrhea; infertility; sinehii the cavity of the uterus; Asherman's syndrome; anti adgesive barriers; antiadgezin. ВведениеВнутриматочные синехии, или синдром Ашермана, это патологическое состояние, ха-рактеризующееся образованием спаек и выро-стов эндометрия с его склерозом и фиброзом. Заболевание названо в честь гинеколога, под-робно описавшего и исследовавшего данную патологию, Джозефа Ашермана (1948-1950).

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“…However, some studies report that these anti-adhesive agents have little effect. 7,8) However, it may be necessary to consider whether the use of these anti-adhesive agents is really effective in patients who have been repaired after ruptured rotator cuff, or whether this is a simple commercial strategy.…”

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confidence: 99%

EDITORIAL : Considering the Suitability of Anti-adhesive Agents Used after a Repair of Rotator Cuff Tears

Moon¹

2017

Clinics in Shoulder and Elbow

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A Randomized, Multi-Center, Clinical Trial to Assess the Efficacy and Safety of Alginate Carboxymethylcellulose Hyaluronic Acid Compared to Carboxymethylcellulose Hyaluronic Acid to Prevent Postoperative Intrauterine Adhesion

Cited by 44 publications

References 23 publications

Effectiveness of the Anti-adhesive Agent Protescal after Arthroscopic Rotator Cuff Repair: A Retrospective Study

Effectiveness of the Anti-adhesive Agent Protescal after Arthroscopic Rotator Cuff Repair: A Retrospective Study

Experience of application anti adgesivebarrier in the treatment of patients with Asherman’s syndrome

EDITORIAL : Considering the Suitability of Anti-adhesive Agents Used after a Repair of Rotator Cuff Tears

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