A Randomized, Double-Blinded Placebo Controlled Crossover Study Evaluating 0.03% Tacrolimus Ointment Monotherapy in the Treatment of Discoid Lupus Erythematosus in Dogs

Messinger, Linda

doi:10.15226/2381-2907/3/1/00125

Cited by 8 publications

(15 citation statements)

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“…In our study, a remarkable improvement or a complete remission in GDLE skin lesions followed treatment with ciclosporin along with a short course of glucocorticoids at its onset. Given that ciclosporin and tacrolimus share a similar mechanism of action on T‐lymphocytes, and that tacrolimus ointment has been used successfully for topical treatment of human and canine localized DLE, we had inferred that ciclosporin might be beneficial for treatment of canine GDLE. Interestingly, ciclosporin is no longer recommended for treatment of human CLE due to a relatively unfavourable risk–benefit profile …”

Section: Discussionmentioning

confidence: 99%

Clinical and microscopic features of generalized discoid lupus erythematosus in dogs (10 cases)

Banović

Linder

Uri

et al. 2016

Veterinary Dermatology

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Background -Generalized discoid lupus erythematosus (GDLE) is a newly recognized canine variant of chronic cutaneous lupus erythematosus (CLE) that is not well characterized.Hypothesis/Objectives -We report herein the signalment, clinical signs, treatment outcome, histopathology and immunological findings of 10 dogs with GDLE.Methods -Inclusion criteria were: (i) a >3 month history of generalized skin lesions indicating a chronic or recurrent nature; (ii) skin lesions resembling those of human GDLE; (iii) histopathology of CLE (lymphocyte-rich interface dermatitis). Direct immunofluorescence (IF) and antinuclear antibody serology were investigated whenever possible.Results -Various breeds were affected in their mid-to late adulthood. Selection criteria of generalized multifocal, annular ("discoid") to polycyclic plaques with pigment changes, erythematous margin, adherent scaling, follicular plugging and central alopecia were shown in all dogs. In nine dogs, plaques contained mild to moderate central scarring with depigmentation and/or hyperpigmentation. There were no dogs in which the disease progressed to systemic lupus erythematosus within a median follow-up of 2.5 years. Per inclusion criteria, interface dermatitis occurred with basement membrane zone (BMZ) thickening, suprabasal apoptosis and/or dermal fibrosis in some dogs. Infundibular interface folliculitis was common; it sometimes transitioned to mural folliculitis in lower follicle segments, and occurred with follicular and sebaceous gland atrophy. The direct IF revealed patchy deposition of immunoglobulin IgG and IgM at the BMZ. Lesions responded to a variety of treatments, including ciclosporin, hydroxychloroquine, topical tacrolimus and tetracycline/niacinamide. Relapses were common after medications were tapered.Conclusions and clinical importance -These observations support the existence of a canine homologue of human GDLE.

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Section: Discussionmentioning

confidence: 99%

Clinical and microscopic features of generalized discoid lupus erythematosus in dogs (10 cases)

Banović

Linder

Uri

et al. 2016

Veterinary Dermatology

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“…The four largest series of dogs with the “classic” localized facial-predominant DLE (FDLE) allows the analysis of a cohort of 104 dogs [ 3 , 4 , 45 , 51 ]. Among these cases, there were 32 German shepherd dogs and their crosses (31%).…”

Section: Chronic Cutaneous Lupus Erythematosusmentioning

confidence: 99%

“…In humans affected with the generalized variant of GDLE, a positive ANA titer is frequently found, and it represents a risk factor for development of SLE within five years after the initial diagnosis of skin lesions [ 56 ]. So far, out of the 104 dogs with classic FDLE included in the four largest series of cases, there were no reports of progression to SLE [ 3 , 4 , 45 , 51 ]. Seven dogs with GDLE had a low positive ANA serum titer, but a progression with acquisition of additional criteria for SLE was not seen in any dog within the median follow up of 2.5 years (ranging 0.5 to 6 years) in the published series [ 10 ].…”

Section: Chronic Cutaneous Lupus Erythematosusmentioning

confidence: 99%

“…There was a positive response in eight dogs (80%), three of them having had an excellent improvement in skin lesions [ 66 ]. Recently, Messinger and colleagues conducted a randomized, double-blinded, placebo-controlled crossover study to evaluate the efficacy of a lower concentration of tacrolimus ointment (0.03%) in 19 dogs with FDLE [ 51 ]. Tacrolimus ointment, applied twice daily as monotherapy for up to 10 weeks, appeared safe and effective.…”

Section: Chronic Cutaneous Lupus Erythematosusmentioning

confidence: 99%

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Cutaneous lupus erythematosus in dogs: a comprehensive review

2018

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Since the first description of discoid lupus erythematosus (LE) in two dogs in 1979, the spectrum of canine cutaneous lupus erythematosus (CLE) variants has expanded markedly.In this review, we first propose an adaptation of the Gilliam-Sontheimer classification of CLE for dogs. We then review the signalment, clinical signs, laboratory and histopathology and treatment outcome of the currently recognized variants of canine CLE, which are vesicular CLE, exfoliative CLE, mucocutaneous LE and facial or generalized discoid LE. We end with a short description of the rare cutaneous manifestations of systemic LE in dogs.Canine CLE variants are heterogeneous, some of them mirror their human counterparts while others appear—thus far—unique to the dog. As most CLE subtypes seem to have a good prognosis after diagnosis, veterinarians are encouraged to become familiar with the spectrum of often-characteristic and unique clinical signs that would permit an early diagnosis and the rapid implementation of an effective treatment.

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“…This small retrospective case series suggests that oral or topical CIs represent an effective therapeutic option with minimal long‐term adverse effects for dogs with VCLE. Because they are potent T‐cell inhibitors, ciclosporin and tacrolimus have been used successfully for treatment of several canine CLE variants, such as exfoliative CLE (ECLE), mucocutaneous lupus erythematosus (MCLE), and localized and generalized discoid lupus erythematous (DLE) . The dosage of ciclosporin used in the present study (5.0–10.0 mg/kg) mirrored those administered in dogs with generalized DLE and ECLE .…”

Section: Discussionmentioning

confidence: 99%

Therapeutic effectiveness of calcineurin inhibitors in canine vesicular cutaneous lupus erythematosus

Banović

Robson²,

Линек

et al. 2017

Veterinary Dermatology

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A Randomized, Double-Blinded Placebo Controlled Crossover Study Evaluating 0.03% Tacrolimus Ointment Monotherapy in the Treatment of Discoid Lupus Erythematosus in Dogs

Cited by 8 publications

References 0 publications

Clinical and microscopic features of generalized discoid lupus erythematosus in dogs (10 cases)

Clinical and microscopic features of generalized discoid lupus erythematosus in dogs (10 cases)

Cutaneous lupus erythematosus in dogs: a comprehensive review

Therapeutic effectiveness of calcineurin inhibitors in canine vesicular cutaneous lupus erythematosus

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