A randomized double blinded placebo controlled clinical trial for the evaluation of green coffee extract on immune health in healthy adults

Narayanaperumal, Jeyaparthasarathy; D'souza, Avin; Miriyala, A.; Sharma, Barun Kumar; Gopal, G

doi:10.1016/j.jtcme.2022.01.007

Cited by 5 publications

(4 citation statements)

References 74 publications

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“…IgG is the most prevalent antibody type present in all bodily fluids and contributes significantly to humoral immunity ( 19 ). IgG serves as the primary antibody in re-immune response and possesses various functions, including phagocytosis, neutralization of toxins and viruses, mediation of antibody-dependent cell-mediated cytotoxicity (ADCC), and activation of the classical pathway of complement ( 20 ).…”

Section: Immunoglobulinmentioning

confidence: 99%

B cells present a double-sided effect in digestive system tumors: a review for tumor microenvironment

Xu,

Lu,

Yang

et al. 2024

Transl Gastroenterol Hepatol

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Over the past few years, there has been an increasing interest in investigating tumor-infiltrating lymphocytes. B lymphocytes (B cells) are extensively distributed within tertiary lymphoid structure (TLS) as multifaceted subgroups and are intimately linked to the anti-tumor properties of TLS, as well as the survival and prognostication of individuals. While the investigation of T lymphocytes in the TLS has advanced to the level of clinical practice, the study of B cells remains limited. The principal impediment to the utilization of B cells in immunotherapy is their notable dual impact on tumors. Compared with tumors in other parts and systems, the function of B cells in the microenvironment of digestive system tumors to promote tumors proliferation, differentiation and migration cannot be ignored. Therefore, this review collects the studies of B cell subsets in tumor microenvironments, particularly related single cell sequencing research. The multifaceted role and function of B cells are investigated in esophageal, liver, colorectal, gastric and pancreatic cancers. And through the identification of B cell subsets and specific markers, this review attempts to explain the reasons why B cells produce different tumor-promoting effects in those tumors. The insights gleaned from this review may provide potential help and support the development of B cell-based immunotherapies.

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Section: Immunoglobulinmentioning

confidence: 99%

B cells present a double-sided effect in digestive system tumors: a review for tumor microenvironment

Xu,

Lu,

Yang

et al. 2024

Transl Gastroenterol Hepatol

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“…However, consumption of excessive sugar without caffeine promoted Th17 responses and exacerbated inflammation in a mouse model of EAE 10 . Coffee extract enhances natural killer (NK) cell activity and monocyte phagocytosis and inhibits monocyte chemoattractant protein 1 (MCP‐1)‐induced monocyte migration 11 . However, the complete molecular mechanism underlying the association between coffee consumption and immune remodeling remains unclear.…”

Section: Introductionmentioning

confidence: 99%

Metabolic shifts during coffee consumption refresh the immune response: insight from comprehensive multiomics analysis

Ruan,

Yang,

et al. 2024

MedComm

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Coffee, a widely consumed beverage, has shown benefits for human health but lacks sufficient basic and clinical evidence to fully understand its impacts and mechanisms. Here, we conducted a cross‐sectional observational study of coffee consumption and a 1‐month clinical trial in humans. We found that coffee consumption significantly reshaped the immune system and metabolism, including reduced levels of inflammatory factors and a reduced frequency of senescent T cells. The frequency of senescent T cells and the levels of the senescence‐associated secretory phenotype were lower in both long‐term coffee consumers and new coffee consumers than in coffee nondrinking subjects, suggesting that coffee has anti‐immunosenescence effects. Moreover, coffee consumption downregulated the activities of the The Janus kinase/signal transduction and activator of transcription (JAK/STAT) and mitogen‐activated protein kinases (MAPK) signaling pathways and reduced systemic proinflammatory cytokine levels. Mechanistically, coffee‐associated metabolites, such as 1‐methylxanthine, 3‐methylxanthine, paraxanthine, and ceramide, reduced the frequency of senescent CD4+CD57+ T cells in vitro. Finally, in vivo, coffee intake alleviated inflammation and immunosenescence in imiquimod‐induced psoriasis‐like mice. Our results provide novel evidence of the anti‐inflammatory and anti‐immunosenescence effects of coffee, suggesting that coffee consumption could be considered a healthy habit.

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“…Research on the use of various types of natural products as immunomodulators has been carried out, including the immunomodulatory effect of the ethanol extract of the sponge Melophlus sarasinorum on phagocytic activity of macrophage cells in male Balb/C mice at doses of 300 mg/kg BW and 400 mg/kg BW [18]; alginic oligosaccharides (osa) produced from alginate from Sargassum crassifolium [19]; green coffee extract reduce inflammation and modulation of immunological [20]; dried lemon peel improves antioxidant activity, immune response and modulates immuno-antioxidant genes [12]; and the role of a natural immunomodulator (Aloe vera) in the cellular and humoral immune system [11]. The immune system maintains the balance of immune homeostasis.…”

Section: Introductionmentioning

confidence: 99%

“…However, when the Covid 19 virus weakens the immune system, an imbalance in the immune response occurs. Nutrients derived from natural ingredients play an important role in regulating immune homeostasis [20]. The general public and health professionals need to be educated about the potential of natural ingredients as immunomodulators.…”

Section: Introductionmentioning

confidence: 99%

Education of the potential of natural ingredients as an immunomodulator in the transition process from pandemic to endemic Covid-19 through webinar

Sari,

Widyasari

2023

J. Pemberdaya. Publ. Has. Pengabdi. Kpd. Masy

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Covid-19 is a respiratory infection caused by the coronavirus. Early prevention of Covid-19 can be done by increasing the body's resistance. Therefore, using traditional plants, which are included in the immunomodulatory group, is alternative prevention. This PkM webinar aims to introduce and educate the public and pharmacists about the potential of natural ingredients in the transition process from the pandemic. PkM is conducted through webinars. The webinar results were analyzed through a pre-test and post-test, and then the data was processed using the t-test. Evaluation of activities was carried out using a Likert scale. The results obtained from this PkM webinar are an increase in participants' knowledge, indicated by a significant difference between the pre and post-test results after being given PkM material, and the opinion of the webinar participants regarding the PkM webinar that was followed was excellent. This activity is expected to provide understanding and education in the potential of natural ingredients as immunomodulators. It is also essential to implement this as a means of education and provide benefits to the teaching and learning process as an evaluation and improvement of student's ability to think critically

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A randomized double blinded placebo controlled clinical trial for the evaluation of green coffee extract on immune health in healthy adults

Cited by 5 publications

References 74 publications

B cells present a double-sided effect in digestive system tumors: a review for tumor microenvironment

B cells present a double-sided effect in digestive system tumors: a review for tumor microenvironment

Metabolic shifts during coffee consumption refresh the immune response: insight from comprehensive multiomics analysis

Education of the potential of natural ingredients as an immunomodulator in the transition process from pandemic to endemic Covid-19 through webinar

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