A randomized, double‐blinded crossover trial testing the benefit of two hydrolysed poultry‐based commercial diets for dogs with spontaneous pruritic chicken allergy

Bizikova, Petra; Olivry, Thierry

doi:10.1111/vde.12302

Cited by 30 publications

(39 citation statements)

References 24 publications

(74 reference statements)

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“…The Anallergenic/Ultamino commercial pet food is used in food trials as reactions to this food are considered likely to be very rare because ten chicken‐allergic dogs were shown to not react to this diet . It cannot be excluded, however, that some cases with a FIAD caused by non IgE‐mediated mechanisms (e.g.…”

Section: Discussionmentioning

confidence: 99%

The usefulness of short‐course prednisolone during the initial phase of an elimination diet trial in dogs with food‐induced atopic dermatitis

Favrot

Bizikova

Fischer

et al. 2019

Veterinary Dermatology

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Background -Food allergy is a possible cause of atopic dermatitis (AD) in dogs; it is typically diagnosed following an eight-week elimination diet trial (EDT) and a provocation with the original diet. This lengthy procedure is difficult for owners and its interpretation may be unclear.Hypothesis/Objectives -To test the effect of prednisolone used in the first weeks of an EDT in order to reduce the total time period for diagnosis. The goal was to perform food challenges earlier than after the traditionally recommended eight weeks.Animals -Fifty-three dogs with AD were included in the study.Methods and materials -All dogs were fed a commercially available extensively hydrolyzed protein-based commercial pet food and treated with prednisolone for at least two weeks to control pruritus and inflammation. Dogs were challenged two weeks after prednisolone finished, provided that no flare had occurred. Dogs with relapsing signs were fed the hydrolyzate for at least eight weeks with or without further prednisolone treatment.Results -Ten of 53 dogs (19%) had no relapse after two weeks off prednisolone: they were subsequently challenged with their regular food, had a relapse of signs and were diagnosed with a food-induced AD within four to six weeks of starting the EDT. In the other dogs, signs remained uncontrolled without prednisolone or relapsed rapidly after its discontinuation: they were considered nonfood-allergic after an eight week EDT.Conclusion and clinical importance -This study demonstrates that a shorter EDT is possible if the allergic pruritus and inflammation are initially controlled with a short course of glucocorticoids. This shortened trial is likely to improve owner adherence and facilitate the diagnosis of food allergy.

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Section: Discussionmentioning

confidence: 99%

The usefulness of short‐course prednisolone during the initial phase of an elimination diet trial in dogs with food‐induced atopic dermatitis

Favrot

Bizikova

Fischer

et al. 2019

Veterinary Dermatology

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“…Careful consideration should be taken when choosing an appropriate elimination diet for each individual dog. A recent study showed dogs with chicken allergy receiving a hydrolysed chicken liver diet had a moderate flare in pruritus, whereas dogs receiving a hydrolysed poultry feather diet did not have flares in pruritus (Bizikova and Olivry 2016); therefore, if chicken allergy is suspected, a different novel protein or hydrolysed poultry feather should be used for diet trials.…”

Section: Differential Diagnosismentioning

confidence: 99%

Concurrent development of generalised demodicosis, dermatophytosis and meticillin‐resistant Staphylococcus pseudintermedius secondary to inappropriate treatment of atopic dermatitis in an adult dog

Lockwood

Mount²,

Lewis

et al. 2017

Vet Record Case Reports

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A four-year-old female spayed mongrel dog was presented in May 2015 with a two-year history of poorly controlled atopic dermatitis (AD) and increased pruritus over the last few months. Current medications included Apoquel, prednisone, diphenhydramine and cephalexin. A deep skin scrape revealed Demodex canis and Demodex cornei and superficial cytology revealed coccoid bacteria. Aerobic skin culture revealed meticillin-resistant Staphylococcus pseudintermedius (MRSP) and dermatophyte culture grew Microsporum canis. Therapy included discontinuation and taper of immunosuppressive medications, oral enrofloxacin and ivermectin and Malaseb shampoo. Complete resolution of demodicosis, dermatophytosis and MRSP was accomplished in four months. Long-term control of AD was established by using low-dose prednisone therapy with no relapse in infectious disease. This case illustrates the risk of development of multiple infectious diseases secondary to immunosuppression with multimodal drug therapy for treatment of AD, and it exemplifies the importance of performing in-house diagnostic testing.

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“…Hydrolysed EDs might represent a potentially valuable tool for the diagnosis of AFR, and able to overcome the above‐mentioned drawbacks of limited antigen diets, yet investigations on undeclared protein content in these diets have not yet been published . Hydrolysis is an enzymatic proteolytic process that cleaves large proteins into small peptides, thereby reducing the allergenicity of food components .…”

Section: Introductionmentioning

confidence: 99%

“…Hydrolysis is an enzymatic proteolytic process that cleaves large proteins into small peptides, thereby reducing the allergenicity of food components . If hydrolysis is incomplete (>10 kDa), these diets retain the ability to induce AFR in dogs allergic to the original protein . Ultrahydrolysed diets (≤10 kDa) have been released on the pet food market.…”

Section: Introductionmentioning

confidence: 99%

An open label clinical trial to evaluate the utility of a hydrolysed fish and rice starch elimination diet for the diagnosis of adverse food reactions in dogs

Matricoti¹,

Noli²

2018

Veterinary Dermatology

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A randomized, double‐blinded crossover trial testing the benefit of two hydrolysed poultry‐based commercial diets for dogs with spontaneous pruritic chicken allergy

Abstract: The hydrolysed poultry feather diet did not induce pruritus flares in dogs allergic to chicken in contrast to the hydrolysed chicken liver diet that led to pruritus flares in 40% of these dogs.

Cited by 30 publications

References 24 publications

The usefulness of short‐course prednisolone during the initial phase of an elimination diet trial in dogs with food‐induced atopic dermatitis

The usefulness of short‐course prednisolone during the initial phase of an elimination diet trial in dogs with food‐induced atopic dermatitis

Concurrent development of generalised demodicosis, dermatophytosis and meticillin‐resistant Staphylococcus pseudintermedius secondary to inappropriate treatment of atopic dermatitis in an adult dog

An open label clinical trial to evaluate the utility of a hydrolysed fish and rice starch elimination diet for the diagnosis of adverse food reactions in dogs

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