A Randomized, Double-Blind Study to Assess the Optimal Duration of Doxycycline Treatment for Human Brucellosis

Solera, J; Geijo, Paloma; Largo, Jorge; Zapata, Manuel Rodríguez; Gijón, Julio; Martı́nez-Alfaro, Elisa; Navarro, Elena; Maciá, M.

doi:10.1086/426024

Cited by 56 publications

(32 citation statements)

References 17 publications

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“…The fairly ideal programme is that taking Deoxycycline 0.1 g, qd orally consecutively for 45 days and the double dose for the first time and using Streptomycin 0.75 g intramuscular injection, qd, for 14 days or using Gentamycin 160,000 U intramuscular injection, bid, for 7 days as the alternative medicine of Streptomycin. Many domestic and overseas scholars find that this method is not very effective, the effective rate is only 60% and has high recurrence rate [1,17,19,20]. Thus, it is necessary to find drugs sensitive to brucellar spondylitis and the drug compatibility and to reevaluate the course of treatment on the base of present drugs.…”

Section: Discussionmentioning

confidence: 99%

The Assessment of the Clinical Effect of the Drug Compatibility and Course of Treatment to the Brucellar Spondylitis

Yang¹,

We²,

Meng³

et al. 2013

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Objective: To evaluate five drug treatment regimens in the treatment of Brucella spondylitis. Methods: Patients with clinical symptoms compatible and diagnostic test consistent with Brucella spondylitis were randomly assigned to five drug treatment regimens. Results: Combination therapy with doxycycline, rifampin and sulfamethoxazole for 56 consecutive days showed the highest cure rate of 20% after a single course and of 85% after a double course with affectivity rates of 55% and 95%. Cure rate and affectivity rate was significant better (P < 0.05) than for patients receiving doxycycline, rifampin and streptomycin for the same period and regimens containing doxycycline were significant better than regimens without this drug. Conclusion: Combination therapy of doxycycline, rifampin and sulfamethoxazole for 8 weeks using one or two full courses should be recommended for Brucella spondylitis.

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Section: Discussionmentioning

confidence: 99%

The Assessment of the Clinical Effect of the Drug Compatibility and Course of Treatment to the Brucellar Spondylitis

Yang¹,

We²,

Meng³

et al. 2013

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“…Relapse usually occurs in patients who received shorter duration of therapy. Relapse rates have been reported as 20.55% and 12.33% in patients treated for 30 and 45 days, respectively [27]. Although the superiority of any particular regimen could not be proved, duration of treatment is recommended at least for three months in the treatment of complications such as osteoarticular involvement [28].…”

Section: Discussionmentioning

confidence: 99%

Age and Duration of Disease as Factors Affecting Clinical Findings and Sacroiliitis in Brucellosis

et al. 2007

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“…The optimal treatment is a combination regimen, since monotherapy has been traditionally associated with an increased percentage of treatment failure and relapse [46,47]. Duration of treatment also matters [48], and 6-week regimens are associated with an acceptable percentage of relapses. The World Health Organization (WHO) endorses regimens that combine doxycycline, 100 mg b.i.d., and rifampicin, 600-1200 mg daily, for 6 weeks, or doxycycline for 6 weeks and streptomycin, 15 mg/kg daily, for 2-3 weeks.…”

Section: Treatmentmentioning

confidence: 99%

Biological weapons

Pappas¹,

Panagopoulou²,

Christou

et al. 2006

Cell. Mol. Life Sci.

215

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Brucella has traditionally been considered a biological weapon. It was the subject of extensive offensive research in the past, and still belongs to category B pathogens on most lists. Its propensity for airborne transmission and induction of chronic debilitating disease requiring combined antibiotic regimens for treatment, its abundance around the world and its vague clinical characteristics defying rapid clinical diagnosis are some of the characteristics that apply to the pathogen's weapons potential. Yet minimal mortality, availability of treatment options, protracted inoculation period and the emergence of new, more virulent potential weapons means that its inclusion among agents of bioterrorism is nowadays mainly of historical significance. Nevertheless, in the interest of literacy and of avoiding panic, physicians and the public both should be aware of the most common zoonosis worldwide.

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A Randomized, Double-Blind Study to Assess the Optimal Duration of Doxycycline Treatment for Human Brucellosis

Abstract: Doxycycline treatment for 45 days significantly decreased early relapse rates among adults with brucellosis without increasing adverse effects.

Cited by 56 publications

References 17 publications

The Assessment of the Clinical Effect of the Drug Compatibility and Course of Treatment to the Brucellar Spondylitis

The Assessment of the Clinical Effect of the Drug Compatibility and Course of Treatment to the Brucellar Spondylitis

Age and Duration of Disease as Factors Affecting Clinical Findings and Sacroiliitis in Brucellosis

Biological weapons

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