A Randomized, Double-Blind, Prospective Pilot Study of Botulinum Toxin Injection for Refractory, Unilateral, Cervicothoracic, Paraspinal, Myofascial Pain Syndrome

Abstract

Although no statistically significant benefit of botulinum toxin type A over placebo was demonstrated in this study, the high incidence of patients who were asymptomatic after a second injection suggests that further research is needed to determine whether higher dosages and sequential injections in a larger cohort might show a botulinum toxin type A effect.

Physical therapy and adjunctive botulinum toxin type A in the treatment of cervical headache: a double-blind, randomised, placebo-controlled study

“…Interestingly, among the 18 patients who underwent retreatment (in open design), 4 of those who had been initially treated with BTX-A did not experience a beneficial effect until the second injection. This is in accordance with the work of Wheeler et al [2], who described better results after repeated injections of BTX-A.…”

Botulinum toxin A, brain and pain

“…Although BoNT/A seems to be a promising candidate for treatment of chronic pain, the results of clinical studies are contradictory, such as the effects on myofacial pain (Cheshire et al, 1994;Göbel et al, 2006;Wheeler et al, 1998) and tension type headache (Relja, 1997;Relja and Telarović, 2004;Schulte-Mattler et al, 2004).…”

Síndrome de dolor miofascial del suelo pélvico: una patología urológica muy frecuente

“…Obtienen resultados esperanzadores al conseguir alivio del dolor y disminuir el hipertonicidad 48,49 . Otros autores solo recomiendan la toxina cuando han fracasado otras medidas terapéuticas más sencillas como la aguja seca 50 . No obstante, Göbel et al comunican en su estudio prospectivo, randomizado y a doble ciego la seguridad de este tratamiento, la buena tolerancia, la rápida resolució n de los efectos secundarios y la mejoría significativa del nivel del dolor 4-6 semanas después del tratamiento 51 .…”