A randomized double-blind placebo-controlled trial to investigate the effectiveness and safety of a novel green-lipped mussel extract -BioLex® -for managing pain in moderate to severe osteoarthritis of the hip and knee

Stebbings, Simon; Gray, Andrew; Schneiders, Anthony G.; Sansom, Andrew J.

doi:10.1186/s12906-017-1907-9

Cited by 31 publications

(40 citation statements)

References 24 publications

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“…Inconsistent findings were observed in GLM extracts (Lau et al, 2004;Stebbings et al, 2017), vitamin E (Brand et al, 2001;Tantavisut et al, 2017), MSM (Kim et al, 2006;Debbi et al, 2011), rose hip (Warholm et al, 2003;Ginnerup-Nielsen et al, 2015), LFO (Kinoshita et al, 2017), ginger (Alipour et al, 2016Altman and Marcussen, 2001;Niempoog et al, 2012;Zakeri et al, 2011) and willow bark extract (Schmid et al, 2001).…”

Section: Dietary Supplements With Mixed Resultsmentioning

confidence: 96%

“…The majority of the studies recruited participants with knee OA (n = 33). Meanwhile, six studies involved participants with either knee or hip OA (Schmid et al, 2001;Warholm et al, 2003;Jacquet et al, 2009;Ginnerup-Nielsen et al, 2015;Hunt et al, 2016;Stebbings et al, 2017), whereas three studies did not state the affected OA region (Belcaro et al, 2008a;Belcaro et al, 2010). The follow-up duration for the included studies ranged from 3 to 32 weeks.…”

Section: Study Characteristicsmentioning

confidence: 99%

“…Eight studies were conducted in European countries (Appelboom et al, 2001;Schmid et al, 2001;Warholm et al, 2003;Cisár et al, 2008;Belcaro et al, 2008a;Jacquet et al, 2009;Belcaro et al, 2010;Ginnerup-Nielsen et al, 2015), five studies in the United States of America (Altman and Marcussen, 2001;Arjmandi et al, 2004;Kim et al, 2006;Frestedt et al, 2009;Pietrzkowski et al, 2014), four in Oceanian countries (Brand et al, 2001;Farid et al, 2010;Hunt et al, 2016;Stebbings et al, 2017) and one study conducted in Africa country (Essouiri et al, 2017). The remaining 23 studies were conducted in Asian countries.…”

Section: Study Characteristicsmentioning

confidence: 99%

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Antioxidant and anti-inflammatory dietary supplements in the treatment of osteoarthritis: a scoping review

Ong¹,

Sakinah²,

Shahril³

et al. 2019

Food Res.

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The increasing number of evidence has reported inflammation and oxidative stress as key mediators of osteoarthritis (OA) joint pathology. Therefore, the usage of dietary supplements targeting inflammation and oxidative stress in OA may emerge as a rewarding therapeutic strategy. This study aimed to explore the efficacy of antioxidant and anti-inflammatory dietary supplements used to manage OA. A methodological framework proposed by Arksey and O’Malley was used to conduct this scoping review. An electronic database search of English academic articles was conducted using PubMed, MEDLINE and ScienceDirect from 2000 to 2018. Randomized controlled trials (RCTs) of OA with parallel groups by comparing dietary supplements with placebo consumption were eligible for inclusion. Out of 69,150 studies identified, a total of 41 studies were included, with 25 antioxidant or anti-inflammatory dietary supplements identified. There were 3325 respondents (1740 in the treatment group and 1585 in the placebo group), all aged ≥ 25 years old and comprised of 69.6% and 30.4% female and male respondents, respectively. The majority of the studies recruited participants with knee OA (n = 33) with a follow-up duration of 3 to 32 weeks. Overall, most of the dietary supplements (n =17) demonstrated a beneficial effect on the clinical signs and symptoms, such as Boswellia serrata extract (BSE), Pycnogenol and L-carnitine. In contrast, Aquamin supplementation did not exert positive impacts on OA management, while inconsistent findings were observed in greenlipped mussel (GLM) extract, vitamin E, methylsulfonylmethane (MSM), licorice flavonoid oil (LFO), ginger, willow bark extract and rose hip supplementation. In summary, the role of anti-inflammatory and antioxidant dietary supplements cannot be ignored as they can offer alleviated pain and symptom relief.

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Section: Dietary Supplements With Mixed Resultsmentioning

confidence: 96%

Section: Study Characteristicsmentioning

confidence: 99%

Section: Study Characteristicsmentioning

confidence: 99%

See 1 more Smart Citation

Antioxidant and anti-inflammatory dietary supplements in the treatment of osteoarthritis: a scoping review

Ong¹,

Sakinah²,

Shahril³

et al. 2019

Food Res.

View full text Add to dashboard Cite

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“…Reports from a couple of clinical trials have advocated effectiveness of P. canaliculus extract in knee osteoarthritis and gastrointestinal dysfunction producing nonsignificant alterations in the gut microbiota (Coulson et al., ; Coulson et al., ). Similarly, the pain‐relieving efficacy of a commercial extract from this mollusk (BioLex) in osteoarthritis has been investigated in a clinical trial, which advocated its effectiveness as a long‐term treatment based on observations in the postintervention period (Stebbings et al., ).…”

Section: Health‐promoting Efficacy Of Marine Mollusksmentioning

confidence: 99%

“…Marine organisms are a major source of food, which are gaining a lot of interest from the scientific community for their nutritional value, and potential role in the functional food and nutraceuticals industry. The health‐promoting effects of many products isolated from marine organisms have been established after successful clinical trials (Coulson, Butt, Vecchio, Gramotnev, & Vitetta, ; Coulson, Vecchio, Gramotnev, & Vitetta, ; Kean et al., ; Stebbings, Gray, Schneiders, & Sansom, ).…”

Section: Introductionmentioning

confidence: 99%

Marine Mollusks: Food with Benefits

Khan

Yang

2019

Comp Rev Food Sci Food Safe

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The extremely vast biodiversity represented by marine mollusks alongside their widespread utility as a source of food and their high nutritional value has aroused great interest from the scientific community. Furthermore, they can be caught with ease, and their commercial breeding and farming is rampant. This article comprehends the global availability of these organisms, their pretreatment and handling procedures, and their health‐promoting potential with a focus on their antiviral, anti‐inflammatory, and antimicrobial properties. The emphasis herein is on their potential use in the food and nutraceutical industry. In addition, mollusks consumption as part of everyday diet can also be helpful in avoiding many ailments as they are rich in vital nutrients and active secondary metabolites, as well as have the ability to enhance immune response. Moreover, the available literature suggests that normal cooking practices have no notable adverse effects on their nutritional value and they retain certain bioactivities even after the action of digestive enzymes. Though mollusks have been widely studied in relation to the health‐promoting effects reviewed here, there is still more scope for further research in this direction in order to fully utilize this enormous source of food and nutraceuticals.

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Green-lipped (greenshell™) mussel (Perna canaliculus) extract supplementation in treatment of osteoarthritis: a systematic review

et al. 2021

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Objectives Intervention studies using New Zealand green-lipped or greenshell™ mussel (GSM) (Perna canaliculus) extract in osteoarthritis (OA) patients have shown effective pain relief. This systematic review summarises the efficacy of GSM extracts in the treatment of OA. Methods A literature search of the three databases EMBASE, MEDLINE, and Scopus was performed to identify relevant articles published up to March 2020. Inclusion criteria were clinical trials published in English measuring the effect of supplementation of whole or a lipid extract from GSM on pain and mobility outcomes in OA patients. Results A total of nine clinical trials were included in systematic review, from which five studies were considered appropriate for inclusion in a forest plot. Pooled results showed that GSM extracts (lipid extract or whole powder) provide moderate and clinically significant treatment effects on a visual analogue scale (VAS) pain score (effect size: − 0.46; 95% CI − 0.82 to − 0.10; p = 0.01). The whole GSM extract improved gastrointestinal symptoms in OA patients taking anti-inflammatory medications. The GSM extract was considered to be generally well tolerated in most of the studies. Conclusion The overall analysis showed that GSM provided moderate and clinically meaningful treatment effects on OA pain. However, the current evidence is limited by the number and quality of studies, and further larger and high-quality studies are needed to confirm the effectiveness and to identify the optimal GSM format. Nevertheless, it is worth considering using GSM extracts especially for patients seeking alternative pain relief treatments with fewer side effects compared to conventional treatment.

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A randomized double-blind placebo-controlled trial to investigate the effectiveness and safety of a novel green-lipped mussel extract -BioLex® -for managing pain in moderate to severe osteoarthritis of the hip and knee

Cited by 31 publications

References 24 publications

Antioxidant and anti-inflammatory dietary supplements in the treatment of osteoarthritis: a scoping review

Antioxidant and anti-inflammatory dietary supplements in the treatment of osteoarthritis: a scoping review

Marine Mollusks: Food with Benefits

Green-lipped (greenshell™) mussel (Perna canaliculus) extract supplementation in treatment of osteoarthritis: a systematic review

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