A Randomized, Double-Blind, Placebo-Controlled Study to Test the Efficacy of Topical 2-Hydroxypropyl-Beta-Cyclodextrin in the Prophylaxis of Recurrent Herpes Labialis

Senti, Gabriela; Iannaccone, Reto; Graf, Nicole; Felder, M; Tay, Fabian; Kündig, Thomas M.

doi:10.1159/000349991

Cited by 13 publications

(12 citation statements)

References 11 publications

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“…Hylander et al reported an overall unchanged allergen‐specific IgG4 levels besides a transient rise in allergen‐specific serum IgE, but increased IgG4 levels in patients showing improved clinics. Senti and Witten reported increased IgG4 and unchanged IgE . Unfortunately, in the only study that compared ILIT and SCIT , IgG4 or other IgG subclasses were not measured.…”

Section: Discussionmentioning

confidence: 99%

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IgG4 but no IgG1 antibody production after intralymphatic immunotherapy with recombinant MAT‐Feld1 in human

Freiberger

Zehnder

Gafvelin

et al. 2016

Allergy

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Allergy immunotherapy (AIT) mediates protection against allergen exposure in part due to allergen-specific antibodies. While immunization typically stimulated IgG1 and IgG2, AIT is often associated with production of IgG4. Here, twenty cat dander-sensitized patients were randomized to receive three injections of intralymphatic immunotherapy (ILIT) with MAT-Feld1 adsorbed to aluminum hydroxide or just aluminum hydroxide (placebo) in a double-blind setting (ClinicalTrials.gov NCT00718679). Whereas the clinical data, showing benefit of Mat-Feld1 ILIT was published in 2012 (Senti et al., J Allergy Clin Immunol, vol 129(5):1290-1296), the current study investigated the cat allergen-specific antibody responses. Blood was drawn prior to ILIT, as well as 1, 3, and 12 months after first ILIT. The sera were analyzed to characterize all IgG subclasses and IgE antibody responses. ILIT with MAT-Feld1 elicited high levels of total IgG that were maintained for at least 12 months. Interestingly, a strong increase in IgG4 and some increase in IgG2 were observed throughout the study, while production of cat-specific IgG1 and IgG3 was not stimulated by MAT-Feld1 ILIT. The IgE levels remained constant.

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Section: Discussionmentioning

confidence: 99%

“…In addition, IgG4 has been reported to favor tolerance by stimulating IL‐10 production in regulatory T cells as well as in B cells . Indeed, increased allergen‐specific IL‐10 production was observed in both ILIT trials that measured IL‐10 .…”

Section: Discussionmentioning

confidence: 99%

IgG4 but no IgG1 antibody production after intralymphatic immunotherapy with recombinant MAT‐Feld1 in human

Freiberger

Zehnder

Gafvelin

et al. 2016

Allergy

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“…IgG4 has been reported to favour tolerance by stimulating IL‐10 production in regulatory T cells as well as B cells . When IL10 was measured in after intralymphatic inguinal injections of birch pollen or grass pollen IL‐10 increased in both cases. IL‐10 was shown to reduce proinflammatory cytokine release from mast cells .…”

Section: Introductionmentioning

confidence: 99%

Immunoglobulin G; structure and functional implications of different subclass modifications in initiation and resolution of allergy

Scott-Taylor

Axinia

Amin

et al. 2017

Immunity Inflam & Disease

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IgE and not IgG is usually associated with allergy. IgE lodged on mast cells in skin or gut and basophils in the blood allows for the prolonged duration of allergy through the persistent expression of high affinity IgE receptors. However, many allergic reactions are not dependent on IgE and are generated in the absence of allergen specific and even total IgE. Instead, IgG plasma cells are involved in induction of, and for much of the pathogenesis of, allergic diseases. The pattern of IgG producing plasma cells in atopic children and the tendency for direct or further class switching to IgE are the principle factors responsible for long‐lasting sensitization of mast cells in allergic children. Indirect class switching from IgG producing plasma cells has been shown to be the predominant pathway for production of IgE while a Th2 microenvironment, genetic predisposition, and the concentration and nature of allergens together act on IgG plasma cells in the atopic tendency to undergo further immunoglobulin gene recombination. The seminal involvement of IgG in allergy is further indicated by the principal role of IgG4 in the natural resolution of allergy and as the favourable immunological response to immunotherapy. This paper will look at allergy through the role of different antibodies than IgE and give current knowledge of the nature and role of IgG antibodies in the start, maintenance and resolution of allergy.

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“…The mean age of the participants is comparable to that of a study from Senti et al, with a mean of 32.6 years. They included patients from 18 to 50 years of age 29 . Clinical trials with a minimum age of 18 result in a higher mean age [30][31][32] .…”

Section: Discussionmentioning

confidence: 99%

Clinical Study on the Effectiveness of Three Products in the Treatment of Herpes Simplex Labialis

Boes

Goulioumis

Wechsler

et al. 2020

Sci Rep

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Herpes simplex labialis (HSL) is a viral disease that affects the perioral region. No guidelines recommending an effective treatment exist. The treatment of HSL with three different products was examined. Herpatch Serum, a film-forming patch, was compared to Compeed Patches, a set of semiocclusive hydrocolloid patches, and Zovirax Cream (ingredient: 5% acyclovir). In this prospective, randomized, examiner-blind study, 180 patients with recurrent HSL were split into three groups (Compeed: n = 60, Herpatch: n = 60, Zovirax: n = 60) and examined within 24 hours of HSL outbreak (DRKS Registration No.: DRKS00007786). The primary endpoint was healing time. The secondary endpoints were the reaction rate and quality of therapy evaluated by the Clinician's Global Assessment of Therapy (CGAT) and the Subject's Global Assessment of Therapy (SGAT) (0 = no response; 10 = excellent response), respectively. There was no significant difference among the healing times for the different products. The mean (95% confidence interval) was 9.67 days (9.11-10.22) for Compeed, 9.30 days (8.75-9.85) for Herpatch, and 9.80 days (9.30-10.30) for Zovirax. The reaction rate and quality of therapy (CGAT and SGAT) of Herpatch were significantly higher than those of Compeed and Zovirax. Within the study limitations, Herpatch proved to be an effective, non-antiviral alternative in the treatment of HSL.Herpes simplex labialis (HSL) is a worldwide infection of the oral and perioral regions caused by an infection with Herpes Simplex Virus type 1 (HSV-1) or, rarely, Herpes Simplex Virus type 2 (HSV-2). Despite the high prevalence of HSL, the disease has not yet been well characterized. The seroprevalence of HSV-1 in Germany was 78.4% from 2008 until 2011 1,2 . While many infections remain subclinical, other patients suffer from painful recurrent infections.Following the primary infection with HSV-1, the virus replicates at the site of infection and proceeds to travel retrograde down unmyelinated sensory fibres to the trigeminal ganglion, where it establishes latency 3 . Interfering triggers such as psychological or physiological stress, UVB radiation, trauma, menstruation, sideropenia or febrile illness can provoke the reactivation of the virus 4,5 .The course of disease in recurrent HSL generally involves several stages. Within the precursor stage, pain, tingling, or burning sensations in the affected area may occur. This is followed by the appearance of a macule, turning into a papule and leading to the formation of a vesicle. The vesicle bursts, and the formation of a soft scab is initiated. Subsequently, the soft scab is replaced by a hard scab. Over time, the scab falls off, and the lesion is fully healed without scarring 6-8 . While healing, the process is often accompanied by symptoms such as pain, discomfort or reduced self-esteem 6 . Complete healing takes seven to ten days 7 .The treatment of recurrent HSL turns out to be very difficult and variable. Because of the slight effects of diverse therapies, the infection represents a constant and...

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A Randomized, Double-Blind, Placebo-Controlled Study to Test the Efficacy of Topical 2-Hydroxypropyl-Beta-Cyclodextrin in the Prophylaxis of Recurrent Herpes Labialis

Cited by 13 publications

References 11 publications

IgG4 but no IgG1 antibody production after intralymphatic immunotherapy with recombinant MAT‐Feld1 in human

IgG4 but no IgG1 antibody production after intralymphatic immunotherapy with recombinant MAT‐Feld1 in human

Immunoglobulin G; structure and functional implications of different subclass modifications in initiation and resolution of allergy

Clinical Study on the Effectiveness of Three Products in the Treatment of Herpes Simplex Labialis

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