A randomized, double-blind, placebo-controlled study on the effect of conjugated estrogens on skin thickness

Maheux, Rodolphe; Naud, F.; Rioux, Michel; Grenier, Raynald; Lemay, André; Guy, Jocelyne; Langevin, Mylaine

doi:10.1016/s0002-9378(94)70242-x

Cited by 204 publications

(69 citation statements)

References 17 publications

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“…The findings from this study are supported by previous experimental evidence showing that estrogen increases extracellular matrix protein production in skin fibroblast cultures of scleroderma patients [62]. In addition, an estrogen-receptor inhibitor (i.e., tamoxifen) induced a significant decrease of these extracellular matrix proteins in cultures of scleroderma skin fibroblasts [62].…”

Section: Reviewsupporting

confidence: 88%

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Rheumatic autoimmune diseases in women and midlife health

Marder

Vinet

Somers

2015

womens midlife health

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Autoimmune diseases such as systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), and systemic sclerosis (scleroderma) preferentially affect women, and are characterized by systemic inflammation leading to target organ dysfunction. The public health burden of autoimmune diseases, which collectively represent a leading cause of morbidity and mortality among women throughout adulthood, is substantial. While some features of these diseases have been observed to improve over the menopausal transition, such as disease flare rate in SLE and skin softening and thinning in scleroderma, others, such as swollen and tender joints and radiographically confirmed damage in RA may worsen. The general trends, however, are not consistent or conclusive for all disease-related manifestations. Of great importance is the recognition that comorbid diseases, including osteoporosis and accelerated cardiovascular disease, contribute excess morbidity and mortality that becomes increasingly apparent as women with autoimmune diseases undergo the menopausal transition.

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Section: Reviewsupporting

confidence: 88%

“…Investigators have observed a mean decline in dermal collagen of approximately 1–2 % per year after menopause [61]. Estrogen supplementation in postmenopausal women has been reported to improve skin thickness by increasing skin collagen content [62]. …”

Section: Reviewmentioning

confidence: 99%

Rheumatic autoimmune diseases in women and midlife health

Marder

Vinet

Somers

2015

womens midlife health

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“…Based on available evidence showing that exogenous estrogen increases skin thickness in normal women, we would have expected the opposite [10,12]. Still, this finding could also represent confounding by disease severity, in which case, women with less severe skin disease and fewer disease complications (such as pulmonary hypertension or cardiovascular disease) would be more likely to be sexually active (and be on OCP) or have fewer contraindications to OCP and/or HRT.…”

Section: Discussionmentioning

confidence: 98%

“…Investigators have reported a mean decline in dermal collagen of approximately 1 to 2% per year after menopause [11]. Estrogen supplementation in postmenopausal women has been shown to increase skin thickness by increasing skin collagen content [12]. …”

Section: Introductionmentioning

confidence: 99%

Effect of menopause on the modified Rodnan skin score in systemic sclerosis

et al. 2014

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IntroductionWe aimed to evaluate the effect of menopause on skin thickening, as measured by the modified Rodnan skin score (mRSS), in women with systemic sclerosis (SSc).MethodsWe identified women with either limited or diffuse SSc, aged ≥ 18 years, enrolled within the Canadian Scleroderma Research Group (CSRG) cohort, between 2004 and 2011. As part of the CSRG cohort, subjects undergo annual assessments with standardized questionnaires and physical examinations. We performed multivariate regression analyses using generalized estimating equation (GEE) to determine the effect of menopause on the mRSS, adjusting for relevant covariates including notably age, follow-up time, and disease duration.ResultsWe identified 1070 women with SSc, contributing a total of 3546 observations over the study period. Of these women, at baseline, 65% had limited disease and 35% diffuse disease. In multivariate analyses, we observed a substantial effect of postmenopausal status on the mean mRSS in women with diffuse disease subtype [−2.62 units, 95% confidence interval (CI) -4.44, −0.80] and significant interaction between menopausal status and disease subtype (2.04 units, 95% CI 0.20, 3.88). The effect of postmenopausal status on the mean mRSS was smaller in women with limited SSc (−0.58, 95% CI −1.50, 0.34).ConclusionsOur results suggest that menopause has a substantial effect on skin thickening in diffuse SSc, with postmenopausal status being associated with a lower mean mRSS compared to premenopausal status.

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“…It is well known that, following menopause, the skin becomes thinner and exogenous estrogen therapy can reverse the process by increasing dermal collagen content [40,41,42,43]. The need for optimal gonadal steroid hormones for proper wound healing has been described in both human and mouse models [44,45,46,47].…”

Section: Discussionmentioning

confidence: 99%

Erosive Pustular Dermatosis: A Manifestation of Immunosenescence A Report of 8 Cases

Thuraisingam

Mirmirani

2017

Skin Appendage Disord

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Erosive pustular dermatosis (EPD) is a rare condition of the scalp and legs that is marked by crusted erosions or superficial ulcerations that may result in scarring alopecia and chronic wounds. The condition predominantly affects elderly female as compared to male patients. Its pathogenesis remains poorly understood. The majority of the cases in the literature are from the United Kingdom and continental Europe. In this series, we present 8 North American patients with EPD of the scalp, one of whom also had involvement of the legs and another with the involvement of the face. All our patients were advanced in age and had a predisposition to chronic actinic damage, which are common characteristics of EPD previously reported in the literature. We hypothesize that immunosenescence leads to an aberrant immune response to wound healing and, along with other factors such as a loss of the normal epidermal barrier, ultraviolet damage, and hormonal factors, may contribute to the development of this condition.

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A randomized, double-blind, placebo-controlled study on the effect of conjugated estrogens on skin thickness

Cited by 204 publications

References 17 publications

Rheumatic autoimmune diseases in women and midlife health

Rheumatic autoimmune diseases in women and midlife health

Effect of menopause on the modified Rodnan skin score in systemic sclerosis

Erosive Pustular Dermatosis: A Manifestation of Immunosenescence A Report of 8 Cases

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