A Randomized, Double-Blind, Placebo-Controlled Study of Testosterone Treatment in Hypogonadal Older Men With Subthreshold Depression

Shores, Molly M.; Kivlahan, Daniel R.; Sadak, Tatiana; Li, Ellen J.; Matsumoto, Alvin M.

doi:10.4088/jcp.08m04478

Cited by 115 publications

(66 citation statements)

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“…In contrast, mood disturbances may be associated with decreased levels of testosterone in both men (Shores et al 2009) and women (Rivera-Woll et al 2004). Previous studies have concluded that testosterone levels are low in patients with both dysthymic disorder and depression (Barrett- Connor et al 1999;Christiansen 2001;Heuser 2002;Seidman et al 2002;Almeida et al 2004;Ebinger et al 2009).…”

Section: Mood and Testosterone Levelmentioning

confidence: 84%

“…A recent placebo-controlled study found that testosterone replacement was effective in older hypogonadal men who suffered from dysthymia or minor depression (Shores et al 2009). Dehydroepiandrosterone also has an important role in mood regulation and may have significant antidepressant effects (Wolkowitz et al 1999;Schmidt et al 2005).…”

Section: Mood and Testosterone Levelmentioning

confidence: 97%

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Testosterone dynamics during encounter: role of emotional factors

et al. 2012

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This study attempts to develop a new theory to explain the varying dynamics of testosterone levels in dominant (winners) and subordinate (losers) males, both pre- and post-encounter. The crux of our new theory consists of the following four theses: (1) the strengthening of testosterone synthesis is a result of not only the existence of challenges, but also of a positive mood before an encounter that is associated with the anticipation of a victory; (2) in situations where the anticipation of victory is present but the positive mood is absent, no rise in testosterone levels will occur; (3) testosterone acts as a "pleasure" hormone and usually releases in situations where the individual achieves or anticipates possible satisfaction; (4) an increased release of testosterone to the blood not only decreases anxiety but also elevates the mood, which increases animal's/human's assertiveness and consequently aggressiveness.

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Section: Mood and Testosterone Levelmentioning

confidence: 84%

Section: Mood and Testosterone Levelmentioning

confidence: 97%

Testosterone dynamics during encounter: role of emotional factors

et al. 2012

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“…Those results prompted us to study the effects of administration of testosterone to men with the MS with hypogonadal values of serum testosterone, including the effects on serum aldosterone. Low testosterone levels in men are associated with the MS as well as with depressive symptoms, low vitality and sexual dysfunction [43,44] . The Aging Mens' Symptoms (AMS) scale [45] was not developed as a screening instrument for androgen deficiency.…”

Section: Introductionmentioning

confidence: 99%

Effects of short-term testosterone administration on variables of the metabolic syndrome, in particular aldosterone

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Gaivoronskaya

et al. 2012

Hormone Molecular Biology and Clinical Investigation

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After 24 weeks of testosterone administration, there were significant declines of insulin and homeostatic model assessment and of serum aldosterone, but no changes in blood pressure. Serum glucose declined but not significantly (p=0.073). There was a slight increase in LDL cholesterol and a decrease in triglycerides. Other variables of MS and other biochemical variables did not change. Echocardiographical variables did not change. The AMS showed improvements over the first 3 months after testosterone administration but, although sustained, there was no further improvement. Short-term testosterone administration over 24 weeks led to some improvements of variables of the MS, notably of aldosterone. Longer-term studies are needed to analyze whether the decrease in serum aldosterone will improve blood pressure and glycemic control.

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“…In a meta-analysis of seven randomized placebocontrolled trials, however, Zarrouf found that there was an overall diminution of depression while on TRT [100]. Another study by Shores showed a 53 % remission of depression while on TRT compared to 19 % placebo [101]. Therefore, while some studies suggest a positive effect, more high-quality studies are needed to establish a more robust link between TRT and depression.…”

Section: Depressionmentioning

confidence: 87%

Update on Testosterone Replacement Therapy in Hypogonadal Men

2015

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Late-onset male hypogonadism has long been recognized as a treatable medical condition; however, misconceptions about the use of testosterone replacement therapy (TRT) have often led urologists away from its more mainstream use. This paper aims to bring the reader up-to-date on the current understanding of TRT, starting with when and who to treat. Various formulations of TRT, each with its own risks and benefits, are also detailed. Finally, a comprehensive analysis of the current literature's views into the various controversies of TRT including its impact on prostate health, sexual health, cardiovascular health, frailty, and mood is discussed.

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A Randomized, Double-Blind, Placebo-Controlled Study of Testosterone Treatment in Hypogonadal Older Men With Subthreshold Depression

Cited by 115 publications

References 0 publications

Testosterone dynamics during encounter: role of emotional factors

Testosterone dynamics during encounter: role of emotional factors

Effects of short-term testosterone administration on variables of the metabolic syndrome, in particular aldosterone

Update on Testosterone Replacement Therapy in Hypogonadal Men

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