A randomized double-blind placebo-controlled clinical study on the effects of gabapentin premedication on hemodynamic stability during laparoscopic cholecystectomy

Abstract

Background:Carbon dioxide pneumoperitoneum for laparoscopic surgery increases arterial pressures, heart rate, and systemic vascular resistance. In this randomized double-blind placebo-controlled clinical study, we investigated the efficacy of gabapentin premedication to provide perioperative hemodynamic stability in patients undergoing laparoscopic cholecystectomy.Materials and Methods:Sixty patients, of either sex (18–65 years of age) undergoing elective laparoscopic cholecystectomy were randomly allocated to two groups of 30 patients each. Patients of group G received oral gabapentin 900 mg 2 h before induction of anesthesia, while patients in group P received placebo at the same time.Results:Mean arterial pressure in patients of group G were significantly lower (P < 0.05) after tracheal intubation and pneumoperitoneum and remained lower, as compared to group P, throughout the pneumoperitoneum. Similarly, heart rate in group G was significantly lower (P < 0.05) after tracheal intubation and pneumoperitoneum and remained lower, in comparison to group P, throughout the peumoperitoneum. Intravenous labetalol was required, to control intraoperative hypertension, in 33.3% (10 out of 30) patients in group P. There was no significant difference in the incidence of adverse effects between the two groups.Conclusion:Gabapentin premedication provided perioperative hemodynamic stability during laparoscopic surgery.

Gabapentin as Premedication for Postoperative Analgesia in Children: A Prospective Randomized Controlled Study

“…while Myung et al found that in rats intrathecal and intraperitoneal gabapentin did not induce significant changes of hemodynamics over the 60 min compared to the baseline value [20]. Mausumi et al found that gabapentin provide hemodynamic stability during laparoscopic surgery in both sexes and this compatible with our study [21].…”

Gabapentin for post‐operative pain management – a systematic review with meta‐analyses and trial sequential analyses

“…A total of 135 studies were included . One hundred and thirty‐two trials with 9498 patients were included for the evaluation of benefit and furthermore, three non‐randomized studies were included for the evaluation of harm.…”

“…Sixteen trials had overall low risk of bias . Seventy‐seven trials had high and 39 trials unclear risk of bias . Reasons for unclear and high risk of bias were mainly ‘selective outcome reporting’ or ‘other bias’ (Fig.…”

Comparison of intrathecal and intravenous clonidine on attenuating haemodynamic response to capnoperitoneum

“…[1][2][3][4] Pharmacological agents like β-blockers, opioids, nitroglycerine and dexmedetomidine have been used to minimize such derangements with varied results. [5][6][7][8][9] Nitroglycerine (NTG) is commonly used as a rescue measure for intraoperative hypertension. 10,11 Clonidine, an -2 adrenoreceptor agonist, reduces sympathetic outflow and is advantageous in laparoscopic procedures.…”