A randomized, double-blind, placebo-controlled 12 week trial of acetaminophen extended release for the treatment of signs and symptoms of osteoarthritis

Prior, Mary Jane; Harrison, Diane D.; Frustaci, Mary Ellen

doi:10.1185/03007995.2014.949646

Cited by 25 publications

(18 citation statements)

References 21 publications

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“…At the same time, IL-1β can also accelerate the synthesis and secretion of matrix metalloproteinase 3 in human cartilage cells through the action of NO to aggravate cartilage matrix damage. Therefore, NO also plays an important role in promoting the occurrence and development of knee osteoarthritis (Prior et al, 2014). NO levels immediately after the exhaustive exercise in both the low-and high-intensity groups was dramatically higher than those in the quiet and pre-exercise groups, indicating that NO levels were upregulated after exhaustion exercise.…”

Section: Discussionmentioning

confidence: 94%

Effects of high intensity exhaustive exercise on SOD, MDA, and NO levels in rats with knee osteoarthritis

Li¹,

Sun²,

Zhu³

et al. 2015

Genet. Mol. Res.

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ABSTRACT. The aim of this study was to investigate the impact of high intensity exhaustive exercise on nitric oxide (NO), malondialdehyde (MDA), and superoxide dismutase (SOD) expression in rats with knee osteoarthritis. Sprague Dawley rats were randomly divided into control (N = 5) and model (N = 35) groups; the model group was further divided into quiet (N = 5), low-(N = 15) and high-(N = 15) intensity exhaustive exercise groups. The low-and high-intensity groups were randomly divided into pre-exercise (N = 5), immediate post-exercise (N = 5), and 24-h post-exercise (N = 5) groups according to different time points for detection. NO, MDA, and SOD levels were compared between each group. The SOD levels in the quiet, low-, and high-intensity exhaustive exercise groups were lower than that in the control group, whereas the NO and MDA levels were higher in the former groups than in the controls (P < 0.05). The SOD level in the 24-h post-low intensity exhaustive exercise group was higher than that in the 24-h post-high intensity exhaustive exercise group, whereas the NO and MDA levels (2015) were lower in the 24-h post-low intensity than in the post-high intensity exercise group (P < 0.05). Overall, the results demonstrated that with the increase of exercise intensity, the SOD activity in the rats with knee osteoarthritis decreased gradually, whereas the MDA and NO levels gradually increased. Thus, the greater the exercise intensity, the more serious the impact on knee osteoarthritis.

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Section: Discussionmentioning

confidence: 94%

Effects of high intensity exhaustive exercise on SOD, MDA, and NO levels in rats with knee osteoarthritis

Li¹,

Sun²,

Zhu³

et al. 2015

Genet. Mol. Res.

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“…Two independent reviewers evaluated 116 potentially relevant studies, and 12 records (13 randomised controlled trials) met the criteria to be included in this review, with one article reporting results of two trials (fig 1 ). 43 44 45 46 47 48 49 50 51 52 53 54 Ten trials reporting data from 3541 patients evaluated the efficacy of paracetamol in patients with osteoarthritis of the hip or knee, 43 44 46 47 48 49 50 51 54 and three trials (1825 patients) investigated the efficacy of paracetamol in people with low back pain. 45 52 53 We did not identify any trials in patients with neck pain.…”

Section: Resultsmentioning

confidence: 99%

Efficacy and safety of paracetamol for spinal pain and osteoarthritis: systematic review and meta-analysis of randomised placebo controlled trials

Machado

Maher

Ferreira

et al. 2015

BMJ

456

281

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Objective To investigate the efficacy and safety of paracetamol (acetaminophen) in the management of spinal pain and osteoarthritis of the hip or knee. Design Systematic review and meta-analysis. Data sources Medline, Embase, AMED, CINAHL, Web of Science, LILACS, International Pharmaceutical Abstracts, and Cochrane Central Register of Controlled Trials from inception to December 2014. Eligibility criteria for selecting studies Randomised controlled trials comparing the efficacy and safety of paracetamol with placebo for spinal pain (neck or low back pain) and osteoarthritis of the hip or knee. Data extraction Two independent reviewers extracted data on pain, disability, and quality of life. Secondary outcomes were adverse effects, patient adherence, and use of rescue medication. Pain and disability scores were converted to a scale of 0 (no pain or disability) to 100 (worst possible pain or disability). We calculated weighted mean differences or risk ratios and 95% confidence intervals using a random effects model. The Cochrane Collaboration’s tool was used for assessing risk of bias, and the GRADE approach was used to evaluate the quality of evidence and summarise conclusions. Results 12 reports (13 randomised trials) were included. There was “high quality” evidence that paracetamol is ineffective for reducing pain intensity (weighted mean difference −0.5, 95% confidence interval −2.9 to 1.9) and disability (0.4, −1.7 to 2.5) or improving quality of life (0.4, −0.9 to 1.7) in the short term in people with low back pain. For hip or knee osteoarthritis there was “high quality” evidence that paracetamol provides a significant, although not clinically important, effect on pain (−3.7, −5.5 to −1.9) and disability (−2.9, −4.9 to −0.9) in the short term. The number of patients reporting any adverse event (risk ratio 1.0, 95% confidence interval 0.9 to 1.1), any serious adverse event (1.2, 0.7 to 2.1), or withdrawn from the study because of adverse events (1.2, 0.9 to 1.5) was similar in the paracetamol and placebo groups. Patient adherence to treatment (1.0, 0.9 to 1.1) and use of rescue medication (0.7, 0.4 to 1.3) was also similar between groups. “High quality” evidence showed that patients taking paracetamol are nearly four times more likely to have abnormal results on liver function tests (3.8, 1.9 to 7.4), but the clinical importance of this effect is uncertain. Conclusions Paracetamol is ineffective in the treatment of low back pain and provides minimal short term benefit for people with osteoarthritis. These results support the reconsideration of recommendations to use paracetamol for patients with low back pain and osteoarthritis of the hip or knee in clinical practice guidelines. Systematic review registration PROSPERO registration number CRD42013006367.

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“…Consequently, APAP is frequently utilized as a model hepatotoxicant [13][14][15], and the precise mechanistic pathways that ultimately result in APAP-induced liver injury are still under investigation [16]. Recent evidence of transient, asymptomatic elevations of liver enzymes in the serum of human subjects receiving APAP in a chronic, therapeutic fashion (2-4 g/day for ≥3 days) has also raised interest in studying the hepatic effects of such treatment [17][18][19][20][21].…”

Section: Introductionmentioning

confidence: 99%

Quantification of a biomarker of acetaminophen protein adducts in human serum by high-performance liquid chromatography-electrospray ionization-tandem mass spectrometry: Clinical and animal model applications

Cook

King

Chang

et al. 2015

Journal of Chromatography B

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A randomized, double-blind, placebo-controlled 12 week trial of acetaminophen extended release for the treatment of signs and symptoms of osteoarthritis

Abstract: Acetaminophen ER 1300 mg, a nonprescription drug, given three times daily, can provide effective relief of signs and symptoms of osteoarthritis of the hip or knee and was well tolerated. ClinicalTrials.gov registration number: NCT00240799.

Cited by 25 publications

References 21 publications

Effects of high intensity exhaustive exercise on SOD, MDA, and NO levels in rats with knee osteoarthritis

Effects of high intensity exhaustive exercise on SOD, MDA, and NO levels in rats with knee osteoarthritis

Efficacy and safety of paracetamol for spinal pain and osteoarthritis: systematic review and meta-analysis of randomised placebo controlled trials

Quantification of a biomarker of acetaminophen protein adducts in human serum by high-performance liquid chromatography-electrospray ionization-tandem mass spectrometry: Clinical and animal model applications

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