A Randomized Double-Blind Placebo-Control Study to Assess the Efficacy and Safety of OLNP-05 Versus Placebo for the Treatment of Subjects with Premature Ejaculation

Traditional, Complementary and Alternative Medicines in the Treatment of Ejaculatory Disorders: A Systematic Review

“…The data extracted from the included studies are summarized in Table 1 based on the type of intervention provided. Proportionately, 31.8% (n = 7) investigated different lifestyle, exercise and/or physical activities [ 58 , 59 , 60 , 61 , 62 , 63 , 64 ]; 22.7% (n = 5) investigated herbal medicine supplements [ 65 , 66 , 67 , 68 , 69 ]; 18.2% (n = 4) investigated topical herbal applications [ 70 , 71 , 72 , 73 ]; 13.6% (n = 3) investigated acupuncture or electroacupuncture [ 74 , 75 , 76 ]; and 4.5% (n = 1) each investigated vitamin, mineral and/or nutraceutical supplements [ 77 ]; hyaluronic acid penile injection [ 78 ]; and music therapy [ 79 ].…”

“…Of the 22 studies included, 95.5% (n = 21) studies investigated the effect of TCAM treatments on patients with PE [ 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 , 75 , 76 , 78 , 79 ], with only 1 study investigating RE [ 77 ]. No studies were identified that investigated TCAM for treating DE, anejaculation or other EjDs.…”

“…No studies were identified that investigated TCAM for treating DE, anejaculation or other EjDs. Of the 21 studies that investigated TCAM in PE, most used the IELT as a primary outcome measure [ 58 , 59 , 60 , 62 , 63 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 , 75 , 76 , 78 , 79 ]. Furthermore, 42.9% (n = 9) used the PEDT alongside IELT [ 59 , 62 , 66 , 68 , 73 , 74 , 76 , 79 ] or as a primary outcome [ 61 ], 9.5% (n = 2) of studies used the PEP alongside IELT [ 67 ] or as a primary outcome [ 61 ], and 9.5% (n = 2) used the CIPE-5 alongside IELT [ 69 , 70 ].…”

“…Of the 21 studies that investigated TCAM in PE, most used the IELT as a primary outcome measure [ 58 , 59 , 60 , 62 , 63 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 , 75 , 76 , 78 , 79 ]. Furthermore, 42.9% (n = 9) used the PEDT alongside IELT [ 59 , 62 , 66 , 68 , 73 , 74 , 76 , 79 ] or as a primary outcome [ 61 ], 9.5% (n = 2) of studies used the PEP alongside IELT [ 67 ] or as a primary outcome [ 61 ], and 9.5% (n = 2) used the CIPE-5 alongside IELT [ 69 , 70 ]. In contrast, individual studies used the AIPE alongside IELT [ 78 ], the MSHQ-EjD alongside IELT [ 66 ], and the CHEES [ 64 ] as primary outcome measures of PE.…”

“…The studies included in this review used a variety of different comparison groups. A placebo comparison was used in 27.3% (n = 6) of studies [ 65 , 67 , 71 , 72 , 73 , 78 ], with 9.1% (n = 2) of studies comparing treatment to a cohort receiving no treatment [ 64 , 69 ]. The use of SSRIs as a comparison group included 22.7% (n = 5) of studies using dapoxetine [ 59 , 60 , 68 , 76 , 79 ] and 4.5% (n = 1) of studies each using paroxetine [ 74 ] and fluoxetine [ 58 ].…”