A randomized, double blind placebo controlled study of efficacy and tolerability of Withaina somnifera extracts in knee joint pain

Ramakanth, G. S. H.; Kumar, Chiranjeevi Uday; Kishan, P. V.; Pingali, Usharani

doi:10.1016/j.jaim.2016.05.003

Cited by 37 publications

(19 citation statements)

References 12 publications

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“…In clinical studies this medicinal plant has been shown to possess anti-microbial, anti-tumor, anti-inflammatory, anti-stress, cardioprotective, neuroprotective, anti-diabetic (Dar et al 2015), analgesic and chondroprotective properties (Ramakanth et al 2016). This medicinal plant is used in the treatment of various diseases like epilepsy, stress, Parkinson's and Alzheimer's disease, arthritis, rheumatism and to improve health and longevity (Pratibha et al 2013).…”

Section: Introductionmentioning

confidence: 99%

Withania somnifera acts as a potential insect growth regulator in the polyphagous pest, Pericallia ricini

Gaur¹,

Kumar²

2018

Journal of Plant Protection Research

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Both seed and root extracts of the medicinal plant, Ashwagandha, Withania somnifera exhibit insect growth regulatory activity against the polyphagous pest, Pericallia ricini. Topical administration of W. somnifera seed and root extracts to last instar larvae of P. ricini disrupted moulting and metamorphosis, leading to a number of developmental abnormalities such as delay in larval-pupal and pupal-adult ecdysis, formation of larval-pupal, pupal--adult and larval-pupal-adult mosaics/chimeras, ecdysial failure, suppression of pupation and adult emergence and formation of abnormal pupae and adultoids. The treatment with seed extracts was more severe than that of root extracts as it completely suppressed the pupation and adult emergence. The results clearly suggest that the medicinal plant, W. somnifera acts as a potential insect growth regulatory (IGR) disrupting the moulting and metamorphosis as a consequence of interference with the endocrine system.

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Section: Introductionmentioning

confidence: 99%

Withania somnifera acts as a potential insect growth regulator in the polyphagous pest, Pericallia ricini

Gaur¹,

Kumar²

2018

Journal of Plant Protection Research

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“…(asoka) 67 9.Acorus calamus L. (vacha) 68 10.Pentatropis capensis Linn. f.(kakanasa) 69 11.Embelia ribes Burm (vidanga) 70 12.Cassia occidentalis Linn (kasamarda) 71 13.Withania somnifera L. (ashwagandha) 72 14. Terminalia arjuna Roxb.…”

Section: Non Pharmacological Approachunclassified

Review of Pain: An Ayurvedic Approach

Mahesh¹,

Wele²,

Patgiri³

et al. 2019

Int. Res. J. Pharm.

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Pain is a serious problem globally due to its high prevalence and is regarded as the fifth vital sign. The standard methods comprising of NSAID and opioid group, interventional methods and implantable methods; although often very effective, have known adverse effects on gastrointestinal, renal and cardiovascular systems and surgical risks. Ayurvedic pain management comprises of pharmacological and non-pharmacological approaches. In this review, we have discussed pain management using herbal and herbomineral formulations. We began with comparison of Ayurvedic concept of pain with that of Biomedicine to arrive at concurrence and then systematically searched the databases PubMed and Scopus using search terms 'pain management, animal models of pain, Ayurveda and herbal medicine'. Out of 160 initial papers, 16 studies involving a total of 1591 participants befitting inclusion criteria were analyzed for the type of pain, intervention, outcome measures and results and others were rejected. PRISMA is followed to report the findings. Studies on Ayurvedic medicines were conducted in three different countries. Eight of them were RCT's with five multi-centered studies. Three single herbs, six polyherbal formulation, one herbomineral formulation and various external therapies were identified. The studies used standard scales like VAS or WOMAC index for analyzing the intensity of pain and showed statistically significant results to Ayurvedic medications in various pain conditions without any adverse effects. This review gives a comprehensive understanding of the concept of pain and its management from both Biomedicine and Ayurveda. It also highlights the unexplored potential of many herbomineral formulations to treat pain.

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“…Compared to placebo, root extract of W. somnifera in doses 250 mg and 125 mg showed significant reductions in mean modified WOMAC score, Knee Swelling Index and VAS scores for pain, stiffness and disability. 40…”

Section: Withania Somniferamentioning

confidence: 99%

Adjuvant drugs in management of osteoarthritis: spotlight on type II collagen

Kakatkar¹,

Pal

Reddy³

et al. 2019

Int J Res Orthop

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<p>Osteoarthritis (OA) is a common musculoskeletal disorder that affects large and small joints and is seen in all ages due to diverse aetiologies. Pain, joint stiffness and limitation of daily activities affects the quality of life of individuals with OA. Conventional analgesics like non-steroidal anti-inflammatory drugs affect pain and inflammatory component but do not target the disease pathogenesis. Damage to the joint cartilage is central to the pathogenesis of OA. Better understanding of the pathogenesis has led to evolution of various adjuvant drugs in management of OA. Among them, undenatured type II collagen induces immune tolerance and thereby provide benefits by reducing the joint damage. Studies assessing efficacy and safety of undenatured type II collagen in OA have shown to reduce clinical symptoms like pain, joint stiffness and improvement in physical activities, and thus improving the quality of life. It is well tolerated and safe for use in OA. This article discusses the pathophysiology of OA with inflammation and beyond, and overviews the various drugs that are used as adjuvants in the management of OA with special focus on the use of type 2 collagen.</p>

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A randomized, double blind placebo controlled study of efficacy and tolerability of Withaina somnifera extracts in knee joint pain

Cited by 37 publications

References 12 publications

Withania somnifera acts as a potential insect growth regulator in the polyphagous pest, Pericallia ricini

Withania somnifera acts as a potential insect growth regulator in the polyphagous pest, Pericallia ricini

Review of Pain: An Ayurvedic Approach

Adjuvant drugs in management of osteoarthritis: spotlight on type II collagen

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