A Randomized Double-blind Controlled Trial of Lactobacillus acidophilus Plus Bifidobacterium bifidum versus Placebo in Patients with Hypercholesterolemia

Rerksuppaphol, Sanguansak; Rerksuppaphol, Lakkana

doi:10.7860/jcdr/2015/11867.5728

Cited by 33 publications

(31 citation statements)

References 23 publications

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“…Regarding the overall effects of probiotic food and supplements on cholesterol levels, only one study showed that interventions had significantly lowered the TC, LDL-C, and HDL-C levels [48]. However, in the other 4 studies, the researchers did not find significant effects on all these 3 (TC, LDL-C, and HDL-C) indicators [47,54,62,64].…”

Section: Change Of Biochemical Indicatorsmentioning

confidence: 76%

“…In addition, there were no significant differences observed in the TC level in the other 2 studies [42,55]. In the 7 studies that evaluated the changes of the triglycerides level, none of them reported significant differences [42,43,48,50,55,56,64]. In order to perform calculation, the researchers standardized the unit-of-measurement to conduct the metaanalysis, lipid levels in mmol/L were converted to mg/dL, and the conversion factor was 1 mmol/L = 38.7 mg/dL for cholesterol and 1 mmol/L = 88.5 mg/dL for triglycerides.…”

Section: Change Of Biochemical Indicatorsmentioning

confidence: 86%

“…Six reviewed studies showed significant differences in the waist circumference, hip circumference, or both [51-53, 55, 56, 59]. While other 5 studies found no significant changes in these anthropometric outcome measurements [42,48,50,52,54].…”

Section: Change Of Anthropometric Indicatorsmentioning

confidence: 99%

“…Upon further examination, 3 studies were removed from the meta-analysis. The reasons for the removal include lack of original data [47], data without specific SD of fasting glucose [48], and outcome indicator being serum glucose, not fasting glucose [42]. Among the remaining 7 studies, 5 of them found no significant differences in fasting glucose or blood glucose in between-group comparisons [38,43,50,55,57].…”

Section: Change Of Biochemical Indicatorsmentioning

confidence: 99%

“…BMI was mentioned as an outcome measurement in 12 studies, which were comprised with 792 study participants. After further examination, 4 studies were excluded from the meta-analysis (Chung et al [47], no original data; Rerksuppaphol and Rerksuppaphol [48], data of BMI was not provided, used BMI z-score, not BMI [49]; Gøbel et al [50], used BMI-for-age z-score, not BMI).…”

Section: Change Of Anthropometric Indicatorsmentioning

confidence: 99%

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Probiotic Foods and Supplements Interventions for Metabolic Syndromes: A Systematic Review and Meta-Analysis of Recent Clinical Trials

Dong

Chen

et al. 2019

Ann Nutr Metab

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Background: Individual clinical trials suggested that when treated with probiotic foods or supplements with Lactobacillus and Bifidobacterium, specific symptoms of metabolic syndrome (MetS) could be alleviated, but the results have been inconclusive. Aims: The objective of the present meta-analysis was to use anthropometric and biochemical as indicators to evaluate the efficacy of using these probiotic foods or supplements among individuals with MetS. Methods: PubMed, Cochrane Library, and CINAHL Plus were used to collect randomized controlled trials (RCTs) studies published from January 2000 to January 2018. Studies were included if they had at least one of the following outcome measurements: body mass index (BMI), waist circumference, hip circumference, waist-to-hip ratio, body fat mass (BFM), body fat percentage (BFP), systolic blood pressure (SBP), diastolic blood pressure (DBP), fasting glucose, fasting insulin, total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), triglycerides, and/or hemoglobin A1c (HbA1c). Results: The 356 records were identified during the literature search, of which only 18 met the selection criteria. The 18 RCTs with a total of 1,544 participants were included in this analysis. This meta-analysis indicated that there were no significant differences of BMI, BFM, waist circumference, hip circumference, waist-to-hip ratio, SBP, DBP, fasting glucose, fasting insulin, TC, HDL-C, HbA1c, or triglycerides between the intervention and control groups. Significant standardized mean net differences were found in the BFP and LDL-C between the intervention and control groups. Conclusions: The results indicated that probiotic food and supplement with Lactobacillus and Bifidobacterium could be used as interventions to improve specific anthropometric and biochemical outcomes among individuals with MetS. However, probiotic treatment alone could not reduce overall health risks. In addition, there were methodological drawbacks among reviewed studies, and further research is needed.

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Section: Change Of Biochemical Indicatorsmentioning

confidence: 76%

Section: Change Of Biochemical Indicatorsmentioning

confidence: 86%

Section: Change Of Anthropometric Indicatorsmentioning

confidence: 99%

Section: Change Of Biochemical Indicatorsmentioning

confidence: 99%

Section: Change Of Anthropometric Indicatorsmentioning

confidence: 99%

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Probiotic Foods and Supplements Interventions for Metabolic Syndromes: A Systematic Review and Meta-Analysis of Recent Clinical Trials

Dong

Chen

et al. 2019

Ann Nutr Metab

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The effects of powdered drinks enriched with curcumin and probiotics on lipid profile and atherogenic indices in patients with metabolic syndrome: A randomized, double‐blinded, placebo‐controlled clinical trial

Mohammadi,

Mohsenpour,

Sohrabi

et al. 2023

Food Science & Nutrition

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Cardiovascular disease is prevalent globally and is the most common complication of metabolic syndrome (MetS). Previous studies have suggested that curcumin and probiotics may improve the lipid profile, so we aimed to investigate the effects of the edible powder enriched with these substances on lipid profile level and atherogenic indices such as Atherogenic Coefficient (AC), Castelli Risk Index‐I (CRI‐I), Castelli Risk Index‐II (CRI‐II), and Atherogenic Index of Plasma (AIP). In the present parallel randomized double‐blinded placebo‐controlled clinical trial, 124 people with MetS with overweight or obesity were randomly allocated to 4 groups and were followed up for 8 weeks. The participants received a low‐calorie diet and a daily sachet of enriched powder drink. The sachets contained either 109 CFU of probiotics or 1 g of curcumin, or probiotic + curcumin (pro + cur), or placebo, respectively. The fasting lipid profile and atherogenic indices were measured at the beginning and end of the study. One hundred and fourteen participants completed the study. At the end of the study, the within‐ and between‐group comparisons showed no significant differences in lipid profile and atherogenic indices (p > .05). Based on the results of the current study, taking an oral powder containing 1 g curcumin and 109 CFU probiotics for 8 weeks had no effect on the lipid profile level and atherogenic indices; however, more studies are recommended.

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Antihypertensive effects of probiotics Lactobacillus strains in spontaneously hypertensive rats

Gómez-Guzmán

Toral

Romero

et al. 2015

Molecular Nutrition Food Res

163

104

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A Randomized Double-blind Controlled Trial of Lactobacillus acidophilus Plus Bifidobacterium bifidum versus Placebo in Patients with Hypercholesterolemia

Cited by 33 publications

References 23 publications

Probiotic Foods and Supplements Interventions for Metabolic Syndromes: A Systematic Review and Meta-Analysis of Recent Clinical Trials

Probiotic Foods and Supplements Interventions for Metabolic Syndromes: A Systematic Review and Meta-Analysis of Recent Clinical Trials

The effects of powdered drinks enriched with curcumin and probiotics on lipid profile and atherogenic indices in patients with metabolic syndrome: A randomized, double‐blinded, placebo‐controlled clinical trial

Antihypertensive effects of probiotics Lactobacillus strains in spontaneously hypertensive rats

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