A randomized double-blind comparative study of terbinafine and griseofulvin in tinea capitis

Terbinafine hydrochloride oral granules versus oral griseofulvin suspension in children with tinea capitis: Results of two randomized, investigator-blinded, multicenter, international, controlled trials∗

“…[20][21][22]24 Similarly, mycologic cure rates with griseofulvin therapy have been reported to range from 62% to 96% with 8 to 12 weeks of therapy. 24,25,[35][36][37] The relatively low cure rates seen in our study may be attributed to several reasons, including and beyond disease characteristic and drug dose. It may at least have been partially due to the absence of adjunctive therapy with topical antifungal agents or ketoconazole shampoo; these are used in the routine management of tinea capitis.…”

Oral Terbinafine in the Treatment of Griseofulvin-resistant Tinea capitis et faciei et corporis in a 10-month-old Girl

“…However, a number of patients do not respond and extended duration of therapy leads to problems in compliance and/or unwanted side e¡ects (1,2,6). Terbina¢n^the ¢rst orally active allylamine^has been available for a couple of years now.…”

“…It has a fungicidal activity against many species, especially dermatophytes (5), and its penetration into sebum and hair is explained by its lipophilic quality. The drug is only slowly released from hair and skin glands (4), which may explain the e¤cacy even in short-term therapy (6,7). Many studies in adults have shown high response rates and good tolerability in tinea corporis and onychmycosis (3).…”

“…There have been only a few open studies and case reports which show a good tolerability and high response rates (73^100%), especially in tinea capitis (4,6,7). However, Microsporum canis infection may cause some problems (8,9).…”

Tinea capitis

“…Selten wird das Auftreten einer toxischen epidermalen Nekrolyse oder eines StevensJohnson-Syndroms berichtet [11]. Eine Kontrolle des Blutbildes sowie der Leberenzyme vor und während der Therapie wird angeraten [6,28,30]. Tabelle 2 und 3 geben eine Übersicht über Neben-und Wechselwirkungen der Substanz.…”