A randomized cross-over study to evaluate the swallow-enhancing and taste-masking properties of a novel coating for oral tablets

Uloza, Virgilijus; Ulozienė, Ingrida; Gradauskienė, Eglė

doi:10.1007/s11096-010-9399-4

Cited by 14 publications

(22 citation statements)

References 4 publications

(4 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Uloza et al . investigated the effects of tablet coating on swallowing performance in healthy volunteers . The authors showed that a surface coating enabled the subjects to swallow easily, although evaluation was based only on the subjects' comparative opinions.…”

Section: Discussionmentioning

confidence: 99%

How do tablet properties influence swallowing behaviours?

Yamamoto

Taniguchi

Hayashi

et al. 2013

Journal of Pharmacy and Pharmacology

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

How do tablet properties influence swallowing behaviours?

Yamamoto

Taniguchi

Hayashi

et al. 2013

Journal of Pharmacy and Pharmacology

View full text Add to dashboard Cite

show abstract

“…Several technologies have been developed to aid the swallowing of solid oral dosage forms. A disposable device called MedCoat ® (Med Coat AB, Stockholm, Sweden) can be used by the patient to apply a thin coat on the tablet before swallowing [ 71 ]. The coating contains gelatine, sweeteners and flavouring agents and can improve the taste of the tablet.…”

Section: Factors Affecting Acceptability Of Tablets and Capsulesmentioning

confidence: 99%

“…The coating contains gelatine, sweeteners and flavouring agents and can improve the taste of the tablet. In a clinical trial (average age 30 years), the coating improved the ease of swallowing of tablets, especially bitter-flavoured placebo tablets [ 71 ]. A similar flavoured spray product Pill Glide ® (FLAVORx Inc., Columbia, MD, USA) requires the patient to apply the spray to the back of the mouth and tongue before taking tablets or capsules [ 72 ].…”

Section: Factors Affecting Acceptability Of Tablets and Capsulesmentioning

confidence: 99%

Patient-Centered Pharmaceutical Design to Improve Acceptability of Medicines: Similarities and Differences in Paediatric and Geriatric Populations

Liu

Ranmal

Batchelor

et al. 2014

Drugs

196

167

View full text Add to dashboard Cite

Patient acceptability of a medicinal product is a key aspect in the development and prescribing of medicines. Children and older adults differ in many aspects from the other age subsets of population and require particular considerations in medication acceptability. This review highlights the similarities and differences in these two age groups in relation to factors affecting acceptability of medicines. New and conventional formulations of medicines are considered regarding their appropriateness for use in children and older people. Aspects of a formulation that impact acceptability in these patient groups are discussed, including, for example, taste/smell/viscosity of a liquid and size/shape of a tablet. A better understanding of the acceptability of existing formulations highlights opportunities for the development of new and more acceptable medicines and facilitates safe and effective prescribing for the young and older populations.Electronic supplementary materialThe online version of this article (doi:10.1007/s40265-014-0297-2) contains supplementary material, which is available to authorized users.

show abstract

“…26 A device that applies a thin coating around the pill, giving a smoother and more slippery feel and masking the taste of medications, has been tested. 27 Forty out of 41 healthy participants with pill-swallowing difficulties reported improved pill swallowing using these pill coating devices, with 54% of them finding it “much easier” to swallow whole tablets. 27 The ingredients used in the medicine coatings are mainly from food sources, and the unpublished pharmacological evaluations have generally regarded them as safe in terms of interacting with medications.…”

Section: Methodsmentioning

confidence: 99%

“… 27 The ingredients used in the medicine coatings are mainly from food sources, and the unpublished pharmacological evaluations have generally regarded them as safe in terms of interacting with medications. 27 …”

Section: Methodsmentioning

confidence: 99%

A spoonful of sugar helps the medicine go down? A review of strategies for making pills easier to swallow

Forough¹,

Lau²,

Steadman³

et al. 2018

PPA

View full text Add to dashboard Cite

Solid oral dosage forms such as tablets and capsules are generally the preferred method of drug delivery due to their convenience, cost, and acceptability. However, for many people, it can be a challenge to swallow solid oral medications, even those with healthy swallowing function. This review describes current strategies available to facilitate medication administration to otherwise healthy people with pill-swallowing difficulties. In general, restoring and maintaining the ability to swallow pills whole should ideally be the first choice in managing people with pill-swallowing difficulties. A number of strategies can potentially make it easier to swallow pills whole. These include postural adjustments, using pill-swallowing aids, and teaching pill-swallowing techniques. Where these are not successful or appropriate, then other approaches have to be considered using alternative formulations/routes of administration or deprescribing. If there is no other option, and it is not directly contraindicated for each specific medication dosage form, pills may be modified and mixed in foods and drinks to aid swallowing. In conclusion, people with pill-swallowing difficulties can benefit from a number of strategies designed to facilitate swallowing medications. However, these strategies should be further evaluated with regard to the evidence relating to both their efficacy and safety.

show abstract

A randomized cross-over study to evaluate the swallow-enhancing and taste-masking properties of a novel coating for oral tablets

Cited by 14 publications

References 4 publications

How do tablet properties influence swallowing behaviours?

How do tablet properties influence swallowing behaviours?

Patient-Centered Pharmaceutical Design to Improve Acceptability of Medicines: Similarities and Differences in Paediatric and Geriatric Populations

A spoonful of sugar helps the medicine go down? A review of strategies for making pills easier to swallow

Contact Info

Product

Resources

About