A Randomized Controlled Trial to Compare the Safety and Efficacy of Tadalafil and Tamsulosin in Relieving Double J Stent Related Symptoms

Abstract

Objectives. To evaluate the safety and efficacy of Tadalafil and Tamsulosin in treating Double J stent related symptoms. Methods. In a prospective study, 161 patients with DJ related symptoms were randomized into 3 groups: Group A patients (54), Group B patients (53), and Group C patients (54). They were given Tadalafil, Tamsulosin, and placebo, respectively, at 1st week till removal of DJ stent at 3rd week. All patients completed Ureteral Stent Symptom Questionnaire (USSQ) at 1st week and at 3rd week. The statistical significant difference among groups was determined by the t-test, Kruskal-Wallis test and multivariate analysis were used to assess association of the variables within the three groups, and the level of significance was set at P < 0.05. Results. Tadalafil and Tamsulosin were comparable in relieving urinary symptoms, general health, and work performance (OR = 0.65, 1.8, and 0.92). But Tadalafil was more effective in relieving body pain, sexual problems, and additional problems than Tamsulosin (OR = 5.95, 19.25, and 2.69) and was statistically significant as P < 0.05. Conclusion. Tadalafil was as effective as Tamsulosin in relieving urinary symptom but more effective in relieving sexual symptoms and body pain.

Comparison of the Symptoms of the Patients Who Had DJ Ureteral Stent Procedure After Renal Transplantation and Endoscopic Ureterolithiasis Surgery

“…Hastalarda stente bağlı semptomları gidermede iki ilaç arasında anlamlı fark görülmemiştir. 8 Maldonado-Avila ve ark.nın 51 hasta üzerinde yaptığı çalışmada, 18 yaş üzerindeki hastalar üreteral stent semptom anketi doldurularak değerlendirilmiştir. Hastalar üç gruba ayrılarak bir gruba tamsulosin, bir gruba oksibutinin ve bir gruba ise her iki ilaç kombine edilerek verilmiştir.…”

“…Bu semptomları gidermek için analjezikler, alfa blokerler, antikolinerjikler ve PDE-5 inhibitörleri kullanılmaktadır. 8,11,13 Bu semptomları gidermek için çeşitli DJ kateter tasarımları ve malzemeleri de kullanılmaktadır. 14 Regan ve ark.nın yaptığı çalışmada, 28 renal transplantlı ve 17 farklı ürolojik cerrahi sonrasında DJ üretere stent takılan hastalar değerlendirilmiştir.…”

“…6,7 Bu semptomları azaltmak için analjezikler, antikolinerjikler, fosfodiesteraz tip-5 (PDE-5) inhibitörleri ve alfa blokerler kullanılmaktadır. 8 Literatürde, renal transplantasyon sonrası yerleştirilen DJ stente bağlı semptomları değerlendiren ve tedaviye yönlendiren yeterli çalışma bulunmamaktadır.…”

Effects of Tamsulosin and Tolterodine on double J stent–related symptoms: A double-blind, randomized, placebo-controlled trial

“…15 Many of these studies were not placebo controlled and have not evaluated these side effects in a systematized way by a validated questionnaire.…”

Role of phosphodiesterase inhibitors in stent-related symptoms: a systematic review and meta-analysis

“…Only three studies fulfilled the methodological requirements, i.e., the population base of 280 patients is quite limited. The three randomized control trials collected for analysis in this study are with significant heterogeneity in study design, especially in comparison with different drugs (Aggarwal et al [2]: tadalafil 5 mg vs placebo vs tamsulosin 0.4 mg; Bhattar et al [3]: tadalafil 5 mg vs placebo vs silodosin 8 mg; Tharwat et al [4]: sildenafil 50 mg vs placebo), which made the data less comparable. 2.…”