A Randomized Controlled Trial of Resistance Exercise Training to Improve Glycemic Control in Older Adults With Type 2 Diabetes

Castañeda, Carmen; Layne, Jennifer E.; Munoz-Orians, Leda; Gordon, Patricia L.; Walsmith, Joseph; Foldvari, Mona; Roubenoff, Ronenn; Tucker, Katherine L.; Nelson, Miriam E.

doi:10.2337/diacare.25.12.2335

Cited by 667 publications

(684 citation statements)

References 37 publications

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“…Although we could not measure sarcopenia among our patients, the relationship found between lower muscle strength and a poor protein diet (MNA item 11) in our participants would account for the lack of function, hence affecting HRQoL. Thus, increases in skeletal muscle mass, or even muscle function (34) are not only related to glycemic control (35,36) but it also appears to be important for prevent the decline in function among T2DM patients, particularly with aging. Consequently, efforts should be made to increase physical exercise, which may lead to improvements in muscle strength, in the T2DM population.…”

Section: Discussionmentioning

confidence: 92%

The relationship between nutritional status, functional capacity, and health-related quality of life in older adults with type 2 diabetes: A pilot explanatory study

Alfonso-Rosa

Pozo-Cruz

et al. 2013

The Journal of nutrition, health and aging

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Abstract:Objective: To explore the relationship between nutritional status, functional capacity and healthrelated quality of life (HRQoL) in older adults with type 2 diabetes (T2DM). Design: Cross-sectional study. Setting and participants: Forty two non-insulin dependent older adults from a primary care center in Seville, Spain. Measurements: Function was assessed with a battery of standardized physical fitness tests. Nutritional status was assessed using the Mini Nutritional Assessment (MNA) and the European Quality of Life Questionnaire (EQ-5D-3L) was used to assess HRQoL. Results: There was an association between MNAnutritional status and lower body strength as assessed by the chair sit-stand test (rho= .451; p= .037) and between MNA-nutritional status and EQ-5D-3L-HRQoL (EQ-5D-3Lutility, rho= .553; p<.001 and EQ-5D-3LVAS rho= .402; p<.001). An MNA item by item correlation analysis with HRQoL and lower limb strength demonstrated that HRQoL appears to be related to functional capacity (principally lower body strength, motor agility and cardiorespiratory fitness) among participants. These results were maintained when correlations were adjusted for co-morbidity. Conclusion: Our results demonstrated that nutritional status is moderately associated with HRQoL and lower limb strength in patients with T2DM. Our data suggest that more emphasis should be placed on interventions to encourage a correct diet and stress the needed to improve lower body strength to reinforce better mobility in T2DM population

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Section: Discussionmentioning

confidence: 92%

The relationship between nutritional status, functional capacity, and health-related quality of life in older adults with type 2 diabetes: A pilot explanatory study

Alfonso-Rosa

Pozo-Cruz

et al. 2013

The Journal of nutrition, health and aging

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“…Inclusion criteria included type 2 diabetes mellitus as defined by the American Diabetes Association [13] for at least 6 months and baseline HbA 1c of 6.6% to 9.9%. Potential participants were excluded if they: (1) were receiving insulin therapy; (2) were participating in exercise ≥2 times per week for at least 20 min per session or had been in any resistance training during the previous 6 months; (3) reported changes in oral hypoglycaemic medications during the previous 2 months; (4) reported changes in antihypertensive or lipidlowering agents in the previous month; (5) reported a change of ≥5% in body weight during the previous 2 months; (6) had serum creatinine ≥200 μmol/l; (7) had proteinuria >1 g/24 h; (8) had blood pressure >160/95 mmHg; (9) had restrictions in physical activity due to disease; (10) had other medical conditions making participation inadvisable; or (11) completed fewer than ten of the 12 scheduled exercise sessions during the run-in period.…”

Section: Methodsmentioning

confidence: 99%

“…Meta-analyses and other studies have demonstrated that aerobic and resistance exercise each improves glycaemic control in people with this condition [2][3][4][5][6][7].…”

Section: Introductionmentioning

confidence: 98%

Effects of aerobic exercise, resistance exercise or both, on patient-reported health status and well-being in type 2 diabetes mellitus: a randomised trial

et al. 2009

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Aims/hypothesis The Diabetes Aerobic and Resistance Exercise (DARE) study showed that aerobic and resistance exercise training each improved glycaemic control and that a combination of both was superior to either type alone in patients with type 2 diabetes mellitus. Here we report effects on patient-reported health status and well-being in the DARE Trial. Methods We randomised 218 inactive participants with type 2 diabetes mellitus in parallel to 22 weeks of aerobic exercise (n=51), resistance exercise (n=58), combined aerobic and resistance exercise (n=57) or no exercise (control; n=52). Intervention allocation was managed by a central office. Outcomes included health status as assessed by the physical and mental component scores of the Medical Outcomes Trust Short-Form 36-item version (SF-36) and well-being as measured by the Well-Being Questionnaire 12-item version (WBQ-12); these were measured at the Ottawa Hospital. Results Using a p value of 0.0125 for statistical significance due to multiple comparisons, mixed model analyses indicated that resistance exercise led to clinically but not statistically significant improvements in the SF-36 physical component score compared with aerobic exercise (Δ=2.7 points; p=0.048) and control (i.e. no exercise; Δ=3.3 points; p=0.015). For mental component scores, there were clinically important improvements favouring no (control) compared with resistance (Δ=7.6 points; p<0.001) and combined (Δ=7.2 points; p<0.001) exercise. No effects on WBQ-12 scores were noted. Overall, 59/218 (27%) of participants included in this analysis sustained an adverse event during the course of the study, including 16 participants in the combined exercise group, 19 participants in the resistance exercise group, 16 participants in the Electronic supplementary material The online version of this article

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“…In addition to its important effect on glycemic control, resistance training is a very important intervention because it counteracts the exacerbated loss of muscle strength and functional capacity observed in elderly patients (Castaneda et al 2002;Dunstan et al 2002;Brooks et al 2007;Ibañez et al 2008;Geirsdottir et al 2012). For example, in study of Brandon et al (2003), 24 weeks of resistance training performed at moderate intensity induced increases in muscle strength and mobility in elderly with type 2 diabetes.…”

Section: Functional Capacity In Elderly Diabetic Patientsmentioning

confidence: 99%

Exercise interventions in polypathological aging patients that coexist with diabetes mellitus: improving functional status and quality of life

Cadore

Izquierdo

2015

AGE

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In elderly populations, diabetes is associated with reduced muscle strength, poor muscle quality, and accelerated loss of muscle mass. In addition, diabetes mellitus increases risk for accelerated aging and for the development of frailty syndrome. This disease is also associated with a polypathological condition, and its complications progressively affect quality of life and survival. Exercise interventions, including resistance training, represent the cornerstones of diabetes management, especially in patients at severe functional decline. This review manuscript aimed to describe the beneficial effects of different exercise interventions on the functional capacity of elderly diabetics, including those at polypathological condition. The SciELO, Science Citation Index, MEDLINE, Scopus, SPORTDiscus, and ScienceDirect databases were searched from 1980 to 2015 for articles published from original scientific investigations. In addition to the beneficial effects of exercise interventions on glycemic control, and on the cardiovascular risk factors associated with diabetes, physical exercise is an effective intervention to improve muscle strength, power output, and aerobic power and functional capacity in elderly diabetic patients. Thus, a combination of resistance and endurance training is the most effective exercise intervention to promote overall physical fitness in these patients. In addition, in diabetic patients with frailty and severe functional decline, a multicomponent exercise program including strength and power training, balance exercises, and gait retraining may be an effective intervention to reduce falls and improve functional capacity and quality of life in these patients.

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A Randomized Controlled Trial of Resistance Exercise Training to Improve Glycemic Control in Older Adults With Type 2 Diabetes

Cited by 667 publications

References 37 publications

The relationship between nutritional status, functional capacity, and health-related quality of life in older adults with type 2 diabetes: A pilot explanatory study

The relationship between nutritional status, functional capacity, and health-related quality of life in older adults with type 2 diabetes: A pilot explanatory study

Effects of aerobic exercise, resistance exercise or both, on patient-reported health status and well-being in type 2 diabetes mellitus: a randomised trial

Exercise interventions in polypathological aging patients that coexist with diabetes mellitus: improving functional status and quality of life

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