A randomized controlled trial of combined 5-fluorouracil and low-molecular-weight heparin in management of established proliferative vitreoretinopathy

5-Fluoro-Uracil and Low Molecular Weight Heparin in the Management of Proliferative Vitreo-retinopathy

“…There is no improvement in the outcome in this study. The findings of the study are similar to the reports of two studies done at Moorefield's eye hospital [8,9]. In one study these agents were used in cases with significant PVR like the present one and in the other they were used in all uncomplicated cases of RD.…”

“…This vouches for the safety of the drugs when used intra-vitreally. This is also corroborated by the multiple studies of the Moorefield's group, the French and the Venezuelan workers [4,6,8,9]. Hence in cases with severe PVR, chances of a favourable outcome can be increased by adding 5FU and LMWH to the infusion fluid.…”

Vitreous management in penetrating trauma: primary repair and secondary intervention

“…16 However, this beneficial effect was not found in patients with established PVR. 17 To the best of our knowledge, no study has been carried out to investigate the use of adjunctive therapy in trauma cases to date.…”

The safety profile of alkylphosphocholines in the model of the isolated perfused vertebrate retina

“…This is the reason why a sealed-capsule irrigation device had to be used for the application of 5-fluorouracil as a potential prophylaxis for posterior capsule opacification in the rabbit eye [25]. In the clinical setting, 5-fluorouracil together with low molecular heparin has not been successful in the prevention of PVR formation [11]. For daunorubicin, the ERG in the model of the superfused Table 2 Testing the effects of alkylphosphocholine on the a-wave amplitude.…”

“…Secondly, human lens epithelial cell proliferation was reduced after the administration of APCs, which underlines their potential for the prophylaxis of posterior capsule opacification (PCO), the most common complication of otherwise uneventful cataract surgery [4]. Thirdly, human retinal pigment epithelial cells [5,6] and human Müller glial cells [7] were incubated with antiproliferative concentrations of APCs as a potential prophylaxis for proliferative vitreoretinopathy (PVR), the most severe complication after retinal detachment surgery, often followed by a permanent reduction of central vision [8][9][10][11].…”