A Randomized, Controlled Trial of Oxycodone Versus Placebo in Patients With PostHerpetic Neuralgia and Painful Diabetic Neuropathy Treated With Pregabalin

Long-Term Efficacy of OROS® Hydromorphone Combined with Pregabalin for Chronic Non-Cancer Neuropathic Pain

“…The second was an observational study (very similar in design to the present study) conducted on clinical data of 1,051 patients with chronic non-cancer neuropathic pain that confirmed the long-term (12 months) effectiveness of combination therapy with oxycodone and pregabalin [13]. On the contrary, results from a randomized, placebo-controlled, double-blind study have documented the non-superiority of combination therapy with pregabalin and oxycodone compared with pregabalin monotherapy [24]. However, this study was conducted on a group of 62 patients and observation was limited to a period of only 4 weeks.…”

Recommendations for the Pharmacological Management of Neuropathic Pain: An Overview and Literature Update

“…Generally consistent results were obtained in a trial in which patients with painful DPN were randomized to receive either extendedrelease oxycodone or matching placebo in combination with existing gabapentin treatment 63 ; however, results of a recent trial showed no additional benefit of a low dosage of 10 mg/d of oxycodone vs placebo when combined with pregabalin. 64 In an open-label prospective cohort study of 403 patients with NP, the combination of extended-release oxycodone and pregabalin showed improved pain relief at lower dosages than either medication alone and was associated with improved HRQoL and better tolerability. 65 Recent RCTs have examined the combination of nortriptyline and gabapentin, 66 which was superior to either of these 2 medications administered alone, as well as the combinations of pregabalin and topical 5% lidocaine 67 and sodium valproate and glyceryl trinitrate spray.…”

Porównanie dożylnego i podskórnego podawania insulin na intensywność bólu neuropatycznego u chorych na cukrzycę

“…Pain-related behaviour is an effect of patient views and reactions on pain and furthermore can be modified by the environment [12]. A similar effect of reduction of pain intensity irrespective of the provided treatment was observed in most of the studies that evaluated various forms of therapy [3,4,13].…”