A randomized controlled trial of home monitoring versus hospitalization for mild non-alcoholic acute interstitial pancreatitis: A pilot study

İnce, Ali Tüzün; Şentürk, Hakan; Singh, Vikesh K.; Yıldız, Kemalettin; Danalıoğlu, Ahmet; Çınar, Ahmet; Uysal, Ömer; Kocaman, Orhan; Baysal, Birol; Gürakar, Ahmet

doi:10.1016/j.pan.2014.02.007

Cited by 29 publications

(26 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…As with AP in the nontransplant population, the mainstay of management in the reviewed studies consisted of conservative treatment with intravenous fluids and bowel rest with further surgical management as required (2)(3)(4)6,7,50). Although specifications of therapy are not discussed, this seems to be in line with the recommended treatment of AP in the general population (16).…”

Section: Managementmentioning

confidence: 95%

Acute pancreatitis following adult liver transplantation: A systematic review

Danalıoğlu

Mitchell

Singh³

et al. 2015

Turk J Gastroenterol

Self Cite

View full text Add to dashboard Cite

Although uncommon, acute pancreatitis is a well-recognized, but generally serious, complication following liver transplantation. In addition to being more prevalent in patients who underwent liver transplantation than in the general population, it has a more aggressive course and can be responsible for significant morbidity and mortality. The post-liver transplant population has altered anatomy, increased comorbidities, and requires a myriad of drugs. These characteristics make them different from the pre-transplant population. Despite their retrospective nature, prior studies have identified numerous etiological factors that are associated with an increased risk of acute pancreatitis following liver transplantation. These can be broadly classified into the following four categories: surgical and anatomical factors, infections, post-transplant management, and post-transplant complications. The aim of this systematic review is to assimilate the available information regarding acute pancreatitis following adult liver transplantation to describe the risk factors and natural history of the disease and to highlight possible areas for further investigation.

show abstract

Section: Managementmentioning

confidence: 95%

Acute pancreatitis following adult liver transplantation: A systematic review

Danalıoğlu

Mitchell

Singh³

et al. 2015

Turk J Gastroenterol

Self Cite

View full text Add to dashboard Cite

show abstract

“…Recently, the HAPS has been introduced to identify AP with a nonsevere course. The HAPS contains fewer parameters which can help stratify nonsevere disease within a short time after presentation and to decide whether to admit these patients to a general ward or the critical care unit [7, 18]. We preferred the Imrie and HAPS scoring systems over APACHE II and Ranson’s scoring systems because the predictive power of the latter scoring systems was shown to be poor in previous studies.…”

Section: Methodsmentioning

confidence: 99%

“…Because of concerns about worsening course even in initially mild patients, and due to the lack of established home management strategies, physicians routinely admit all patients to the hospital [7]. Prediction of very mild courses with certainty in the emergency room would have a significant financial impact.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Prediction of Self-Limited Acute Pancreatitis Cases at Admission to Emergency Unit

Kayar

Şentürk

Tozlu

et al. 2018

GE Port J Gastroenterol

Self Cite

View full text Add to dashboard Cite

Background: While acute pancreatitis (AP) resolves spontaneously with supportive treatment in most patients, it may be life-threatening. Predicting the disease severity at onset dictates the management strategy. We aimed to define the patients with mild pancreatitis who may be considered for outpatient management with significant cost-savings. Materials and Methods: This prospective observational study included 180 patients with mild AP according to the harmless acute pancreatitis score (HAPS) and Imrie score. The relationships of biochemical parameters with the changes in the Balthazar score and clinical course were examined. Results: The study included 180 patients (111 females, 69 males; mean age: 53.9 ± 17.2 years; range: 17–92 years). The etiology was biliary in 118 (65%) patients and remained undetermined in 38 (21.1%) patients. Computed tomography (CT) performed within the first 12 h revealed mild and moderate AP in 159 (88.3%) and 21 (11.7%) patients, respectively. CT repeated at 72 h revealed mild, moderate, and severe AP in 155 (86.1%), 24 (13.3%), and 1 (0.6%) patients, respectively. Comparisons between stages A + B + C and D + E showed significant differences in the amylase levels on day 1 and 3, and in C-reactive protein on day 3. Also, in stage D and E disease, narcotic analgesic intake, oral intake onset time, and pain were significantly higher. Conclusion: There were no significant changes in the CT findings of patients with mild AP at 12 and 72 h. Most patients (n = 179; 99.4%) recovered uneventfully. Patients with mild pancreatitis according to the HAPS and Imrie scores can be considered for outpatient management. The recovery is longer in stage D and E disease.

show abstract

“…Another, the bedside index of severity scoring system has been started to use recently (2008) (31). It includes 5 parameters and can be used within the first 48 hours.…”

Section: Innovations In Guidelines and Classificationsmentioning

confidence: 99%

Pathophysiology, classification and available guidelines of acute pancreatitis

İnce

Baysal²

2014

Turk J Gastroenterol

Self Cite

View full text Add to dashboard Cite

Acute pancreatitis (AP) constitutes the majority of cases requiring hospital admission in gastroenterology. We are yet to know many things about its pathophysiology which is a certain drawback for the progress in its treatment. Prediction of severity is necessary for the plan of the management. The existing scoring systems are yet to be satisfactory. However our progress in the field was significant in the recent decade and a leap forward is expected in this cumbersome-to-manage condition which has many unmet needs. In this review, we are going to summarize the hitherto data in pathogenesis and would weigh the usefulnes and weaknes of each of existing scoring systems in the management of AP. Keywords: Acute pancreatitis, guideline, pathophysiology, scoring systems, classifications, insights Pancreas was first discovered by Herophilus, a Greek anatomist and surgeon, in Chalcedon (now Kadıkoy, Istanbul) in 336 BC. Despite the many years since its discovery, a lot remains unknown about pancreas. The coming decade would, probably, witness several advances in our understanding of pancreas and its diseases.This review aims to describe the hitherto knowledge in pancreas pathophysiology and classification systems of severity scoring. PATHOPHYSIOLOGYThe main reason for the lack of successful treatment in acute pancreatitis (AP) is that many aspects of this condition regarding the pathophysiology are still unknown. AP has a severe course in 20% of the cases and may be associated with high morbidity and mortality in 2-3%. Pancreatic autodigestion (trypsinogen-centered) theory has been in use in the AP pathogenesis for over a hundred year. In this theory, premature activation of pancreatic proenzymes (zymogens) induces autolysis, which triggers inflammatory events followed by continued damage to the pancreas and/or non-pancreatic tissues in some way.Experimental models (1,2) have demonstrated the involvement of trypsin activation in hereditary pancreatitis (3). Along with zymogen activation, natural factor kappa beta (NFkB) activation is also important in the development of AP. Whether both are involved or are independently-acting parallel factors in AP is controversial. It was shown, in vitro, that trypsinogen expression did not activate NFkB (4

show abstract

A randomized controlled trial of home monitoring versus hospitalization for mild non-alcoholic acute interstitial pancreatitis: A pilot study

Cited by 29 publications

References 22 publications

Acute pancreatitis following adult liver transplantation: A systematic review

Acute pancreatitis following adult liver transplantation: A systematic review

Prediction of Self-Limited Acute Pancreatitis Cases at Admission to Emergency Unit

Pathophysiology, classification and available guidelines of acute pancreatitis

Contact Info

Product

Resources

About