A Randomized Controlled Trial of the Effects of Mindfulness-Based Stress Reduction (MBSR[BC]) on Levels of Inflammatory Biomarkers Among Recovering Breast Cancer Survivors

Reich, Richard R.; Lengacher, Cecile A.; Klein, Thomas; Newton, Cathy; Shivers, Steven C.; Ramesar, Sophia; Alinat, Carissa B.; Paterson, Carly L.; Le, Alice; Park, Jong Y.; Johnson-Mallard, Versie; Elías, Maya N.; Moscoso, Manolete S.; Goodman, Matthew; Kip, Kevin E.

doi:10.1177/1099800417707268

Cited by 29 publications

(31 citation statements)

References 44 publications

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“…al., (2007) [17] coronary artery bypass graft surgery Yes, diagnosis of depression (15,15) post, 3 and 6 months FUs) Face-to-face at home (individual) Bae, 2012 Combined Pre-Post 0,000 0,421 0,178 -0,826 0,826 0,000 1,000 Bower, 2015 Combined Pre-Post 0,080 0,246 0,061 -0,403 0,563 0,324 0,746 Chen, 2008 Combined Pre-Post 0,395 0,417 0,174 -0,423 1,212 0,946 0,344 Creswell, 2012 Combined Pre-Post -0,051 0,327 0,107 -0,692 0,590 - Bae, 2012 Combined Pre-Post 0,000 0,421 0,178 -0,826 0,826 0,000 1,000 Bower, 2015 Combined Pre-Post 0,080 0,246 0,061 -0,403 0,563 0,324 0,746 Chen, 2008 Combined Pre-Post 0,395 0,417 0,174 -0,423 1,212 0,946 0,344 Creswell, 2012 Combined Pre-Post -0,051 0,327 0,107 -0,692 0,590 -0,156 0,876 Gallegos, 2013 IL-6 Pre-Post 0,047 0,141 0,020 -0,229 0,323 0,333 0,739 CRP Pre-Post 0,529 0,263 0,069 0,014 1,044 2,015 0,044 Menzies, 2014 Combined Pre-Post 0,035 0,248 0,062 -0,452 0,521 0,140 0,889 Oh, 2008 CRP Pre-Post 0,987 0,554 0,307 -0,099 2,072 1,782 0,075 Oh, 2009 CRP Pre-Post 0,404 0,200 0,040 0,012 0,796 2,021 0,043 Oken, 2010 Combined Pre-Post 0,247 0,465 0,216 -0,664 1,157 0,531 0,595 Pakiz, 2011 Combined Pre-Post -0,180 0,255 0,065 -0,679 0,319 -0,707 0,480 Reich, 2017 Combined Pre-Post 0,160 0,112 0,013 -0,059 0,380 1,430 0,153 Richardson, 1997 Combined Pre-Post 0,000 0,368 0,136 -0,721 0,721 0,000 1,000 Sharpe, 2001 CRP Pre-Post 0,201 0,318 0,101 -0,423 0,825 0,631 0,528 Sharpe, 2012 CRP Pre-Post 0,143 0,228 0,052 -0,304 0,590 0,627 0,531 Taylor, 2009 CRP Pre-Post 0,162 0,303 0,092 -0,432 0,757 0,535 0,593 Walsh, 2016 Combined Pre-Post 0,120 0,247 0,061 -0,365 0,605 0,486 0,627 0,150 0,057 0,003 0,039 0,262 2,648 0,008…”

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Effects of psychological interventions on systemic levels of inflammatory biomarkers in humans: A systematic review and meta-analysis

O’Toole

Bovbjerg

Lekander

et al. 2018

Brain, Behavior, and Immunity

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The purpose of the present investigation was to systematically review randomized controlled trials examining the effects of psychological interventions on inflammatory biomarkers in adult populations and to quantitatively analyze those effects by meta-analysis. Two researchers independently searched key electronic databases, selected eligible publications, extracted data, and evaluated methodological quality. Nineteen randomized controlled trials examining a total of 1510 participants were included. The overall combined effect size from pre to post psychological intervention on pro-inflammatory biomarker levels was statistically significant, showing an attenuating effect, although of a small magnitude (s' g = 0.15, p = .008, CI [0.04-0.26]). However, this effect was not maintained into the follow-up period (g < -0.01, p = .964, CI [-0.19-0.18]). Looking at the individual biomarkers assessed across studies, only C-reactive protein (CRP) was found to significantly decrease following psychological intervention. A number of moderation analyses were conducted, none of which reached statistical significance. However, the numerically largest - and significant - within-group effect size was obtained for the group of studies that had preselected participants based on elevated psychological distress (g = 0.29, p = .047). In conclusion, psychological interventions appear efficacious in reducing pro-inflammatory biomarker levels. Future studies are recommended to carefully select individuals based on inflammatory (e.g., the presence of low-grade inflammation) and/or psychological (e.g., psychological distress) criteria.

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Effects of psychological interventions on systemic levels of inflammatory biomarkers in humans: A systematic review and meta-analysis

O’Toole

Bovbjerg

Lekander

et al. 2018

Brain, Behavior, and Immunity

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“…23 TNF-α and IL-6 levels appear to elevate during follow-up after meditation among survivors of breast cancer. 24 There was no alteration in IL-6 levels after meditation in breast cancer patients with adjuvant chemotherapy and/or radiation therapy. 25 Meditation can also monitor the immune system in normal individuals.…”

Section: General Psychiatrymentioning

confidence: 86%

Biological mechanism study of meditation and its application in mental disorders

2020

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In recent years, research on meditation as an important alternative therapy has developed rapidly and been widely applied in clinical medicine. Mechanism studies of meditation have also developed progressively, showing that meditation has great impact on brain structure and function, and epigenetic and telomere regulation. In line with this, the application of meditation has gradually been expanded to mental illness, most often applied for major depressive disorders and substance-related and addictive disorders. The focus of this paper is to illustrate the biological mechanisms of meditation and its application in mental disorders.

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“…Unlike TNF-α that displays consistent patterns following mindfulness interventions, literature reviews and meta-analysis did not report overall decreases or increases for IL-6 following mindfulness interventions, which could be due to this cytokine's sensitivity to variations in clinical trial characteristics (study protocol, population studied, etc.). Nevertheless, some studies did report a rise of IL-6 following mindfulness interventions in populations such as breast cancer patients [88] and healthy adults [89], and this rise was considered beneficial. In the context of AD, however, the overall assumption regarding peripheral levels of IL-6 is that of a gradual augmentation with the progression of the disease [13,90].…”

Section: Discussionmentioning

confidence: 99%

Effects of a Mindfulness-Based Intervention on Circulating Cytokine Levels in Individuals with Amnestic Mild Cognitive Impairment: A Pilot Study

Morin-Alain¹,

Larouche²,

Chouinard³

et al. 2020

OBM ICM

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Peripheral inflammation plays an important role in the pathophysiology of Alzheimer's disease (AD) and dysregulations in circulating levels of different inflammatory mediators are detectable as early as the mild cognitive impairment (MCI) stage towards AD. Depressive symptoms, another risk factor of AD, are often found in individuals with MCI and associated with heightened levels of peripheral inflammatory mediators. Diminution in depressive symptoms and alterations of peripheral inflammation profiles have been observed following Mindfulness-based interventions (MBIs). In this pilot randomized-control trial, the impact of a mindfulness-based intervention (MBI) was compared to that of a psychoeducation-based intervention (PBI) on the peripheral inflammation profile and depressive symptomatology of participants with MCI. Plasma samples and scores on the Geriatric Depression scale (GDS) were obtained from 12 participants per group before and after the 8-week interventions.Flow cytometry allowed for inter-group comparisons of the pro-inflammatory cytokines Interleukin (IL)-6 and Tumor Necrosis Factor (TNF)-α levels. Post-MBI, two tendencies stand out regarding inflammation profiles: 1) a decrease of TNF-α for participants having higher initial levels of this cytokine, and 2) an increase of IL-6 levels for all participants. In the PBI group, the cytokine levels remained unchanged post-intervention. Regarding depressive symptomatology, no significant variations were noted for both groups. Moreover, variations on depressive symptoms and peripheral levels of cytokines were not correlated. MBI could exert a physiological effect on an important feature of AD, namely inflammation. Furthermore, action mechanisms behind physiological and psychological effects of MBIs could stem from independent sources. This remains to be demonstrated with more robust data.

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A Randomized Controlled Trial of the Effects of Mindfulness-Based Stress Reduction (MBSR[BC]) on Levels of Inflammatory Biomarkers Among Recovering Breast Cancer Survivors

Cited by 29 publications

References 44 publications

Effects of psychological interventions on systemic levels of inflammatory biomarkers in humans: A systematic review and meta-analysis

Effects of psychological interventions on systemic levels of inflammatory biomarkers in humans: A systematic review and meta-analysis

Biological mechanism study of meditation and its application in mental disorders

Effects of a Mindfulness-Based Intervention on Circulating Cytokine Levels in Individuals with Amnestic Mild Cognitive Impairment: A Pilot Study

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