A randomized controlled trial for the use of Thymus Honey in decreasing Salivary Gland Damage following Radioiodine Therapy for Thyroid cancer: research protocol

Abstract

The recommended intervention protocol is expected to improve the comprehensive management of salivary gland-related side effects induced by the radioiodine treatment in people diagnosed with thyroid cancer. Through the methodological approach chosen, the ideal intervention protocol in terms of the time to initiate the intervention and the frequency of the intervention to acquire optimal results in minimizing salivary glands damage will be tested.

A systematic review: non‐pharmacological interventions in treating pain in patients with advanced cancer

“…Complementary and alternative medicine (CAM) is popular, and many nurses seem to be embracing it in the hope of helping their patients, as recent publications in JAN show (Chang et al 2012, Zhang et al 2012, Charalambous et al 2014, H€ okk€ a et al 2014. But despite its popularity, CAM has remained a highly controversial area: the evidence-base is often unconvincing or non-existent.…”

Relevance of functional foods in the Mediterranean diet: the role of olive oil, berries and honey in the prevention of cancer and cardiovascular diseases

“…Furthermore, Thyme honey-derived monoterpene induced apoptotic PC-3 cell death, in part by decreasing the secretion of IL-6 and NF-rB (Kassi et al, 2014). In randomized controlled trial, Thyme honey mouthwashes exerted safety and effectiveness for the management of radiation induced salivary gland damage in thyroid cancer patients (Charalambous, Frangos, and Talias 2014) and xerostomia in head and neck cancer patients (Charalambous et al, 2017) Finally, Anatolian honey with diverse botanical origin such as pine, chestnut and cedar exerted more anti-proliferative and apoptotic effects on a panel of breast cancer cells (MCF7, SKBR3, and MDAMB-231) in dose and time manner, while multifloral honey was less effective (Seyhan et al, 2017).…”

Seeking optimal management for radioactive iodine therapy-induced adverse effects

“…The effectiveness of thyme honey will be prospectively studied under varying regimens of lemon candy (standard treatment) and thyme honey mouthwashes (experimental intervention). [ 24 ]…”