A randomized controlled trial comparing Pentazocine and Chamomilla recutita for labor pain relief

Zafar, Shamsa; Najam, Yawar; Arif, Zaeema; Hafeez, Assad

doi:10.1016/j.homp.2015.09.003

Cited by 14 publications

(7 citation statements)

References 24 publications

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“…No adverse events were noted. Chamomile and Pentazocine did not significantly differ from placebo (Zafar et al, 2016).…”

Section: Raspberry Leafmentioning

confidence: 64%

“…Of the 17 clinical trials described here, only 8 studied the efficacy of HMs in pregnant women. Eleven clinical trials explored the effects of ginger (Z. officinale Roscoe) (Fischer-Rasmussen et al, 1991;Vutyavanich et al, 2001;Keating and Chez, 2002;Willetts et al, 2003;Sripramote and Lekhyananda, 2003;Smith et al, 2004;Chittumma et al, 2007;Pongrojpaw et al, 2007;Ensiyeh and Sakineh, 2009;Ozgoli et al, 2009;Sharifzadeh et al, 2018), one studied cranberry (Vaccinium macrocarpon L.) (Wing et al, 2008), one investigated raspberry leaf in tablets (R. idaeus L.) (Simpson et al, 2001), one reviewed garlic (A. sativum L.) (Ziaei et al, 2001), one evaluated the use of St. John's Wort (H. perforatum L.) (Samadi et al, 2010), one clinical trial explored the effects of chamomile (M. chamomilla L.) (Zafar et al, 2016), and another clinical trial investigated peppermint aromatherapy (M. piperita L.) (Joulaeerad et al, 2018).…”

Section: Efficacy and Safety Of Hms Used By Pregnant Womenmentioning

confidence: 99%

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Use of Herbal Medicine by Pregnant Women: What Physicians Need to Know

et al. 2020

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About 80% of the consumers worldwide use herbal medicine (HMs) or other natural products. The percentage may vary significantly (7%-55%) among pregnant women, depending upon social status, ethnicity, and cultural traditions. This manuscript discusses the most common HMs used by pregnant women, and the potential interactions of HMs with conventional drugs in some medical conditions that occur during pregnancy (e.g., hypertension, asthma, epilepsy). It also includes an examination of the characteristics of pregnant HM consumers, the primary conditions for which HMs are taken, and a discussion related to the potential toxicity of HMs taken during pregnancy. Many cultures have used HMs in pregnancy to improve wellbeing of the mother and/or baby, or to help decrease nausea and vomiting, treat infection, ease gastrointestinal problems, prepare for labor, induce labor, or ease labor pains. One of the reasons why pregnant women use HMs is an assumption that HMs are safer than conventional medicine. However, for pregnant women with pre-existing conditions like epilepsy and asthma, supplementation of conventional treatment with HMs may further complicate their care. The use of HMs is frequently not reported to healthcare professionals. Providers are often not questioning HM use, despite little being known about the HM safety and HM-drug interactions during pregnancy. This lack of knowledge on potential toxicity and the ability to interact with conventional treatments may impact both mother and fetus. There is a need for education of women and their healthcare professionals to move away from the idea of HMs not being harmful. Healthcare professionals need to question women on whether they use any HMs or natural products during pregnancy, especially when conventional treatment is less efficient and/or adverse events have occurred as herbaldrug interactions could be the reason for these observations. Additionally, more preclinical and clinical studies are needed to evaluate HM efficacy and toxicity.

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“…No adverse events were noted. Chamomile and Pentazocine did not significantly differ from placebo (Zafar et al, 2016).…”

Section: Raspberry Leafmentioning

confidence: 64%

Section: Efficacy and Safety Of Hms Used By Pregnant Womenmentioning

confidence: 99%

Use of Herbal Medicine by Pregnant Women: What Physicians Need to Know

et al. 2020

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“…The three studies comprising ‘reliable’ RCT evidence are clinically heterogeneous: Plumbum metallicum for lead poisoning ([23]; null effect); Acthéane for menopausal syndrome ([24]; significant treatment effect; evidence of vested interest); Traumeel S for post-operative pain ([25]; null effect). Since the completion of our defined literature search, we are aware of recently published and potentially eligible RCT papers, whose findings we have yet to explore [26–29]. The limit of detecting an effect of non-individualised homeopathy across all trials may be related to a medicine’s degree of dilution, since trials using potency ≥12C failed to show a statistically significant pooled effect that favoured homeopathy (see Fig.…”

Section: Discussionmentioning

confidence: 99%

Randomised, double-blind, placebo-controlled trials of non-individualised homeopathic treatment: systematic review and meta-analysis

et al. 2017

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BackgroundA rigorous systematic review and meta-analysis focused on randomised controlled trials (RCTs) of non-individualised homeopathic treatment has not previously been reported. We tested the null hypothesis that the main outcome of treatment using a non-individualised (standardised) homeopathic medicine is indistinguishable from that of placebo. An additional aim was to quantify any condition-specific effects of non-individualised homeopathic treatment.MethodsLiterature search strategy, data extraction and statistical analysis all followed the methods described in a pre-published protocol. A trial comprised ‘reliable evidence’ if its risk of bias was low or it was unclear in one specified domain of assessment. ‘Effect size’ was reported as standardised mean difference (SMD), with arithmetic transformation for dichotomous data carried out as required; a negative SMD indicated an effect favouring homeopathy.ResultsForty-eight different clinical conditions were represented in 75 eligible RCTs. Forty-nine trials were classed as ‘high risk of bias’ and 23 as ‘uncertain risk of bias’; the remaining three, clinically heterogeneous, trials displayed sufficiently low risk of bias to be designated reliable evidence. Fifty-four trials had extractable data: pooled SMD was –0.33 (95% confidence interval (CI) –0.44, –0.21), which was attenuated to –0.16 (95% CI –0.31, –0.02) after adjustment for publication bias. The three trials with reliable evidence yielded a non-significant pooled SMD: –0.18 (95% CI –0.46, 0.09). There was no single clinical condition for which meta-analysis included reliable evidence.ConclusionsThe quality of the body of evidence is low. A meta-analysis of all extractable data leads to rejection of our null hypothesis, but analysis of a small sub-group of reliable evidence does not support that rejection. Reliable evidence is lacking in condition-specific meta-analyses, precluding relevant conclusions. Better designed and more rigorous RCTs are needed in order to develop an evidence base that can decisively provide reliable effect estimates of non-individualised homeopathic treatment.Electronic supplementary materialThe online version of this article (doi:10.1186/s13643-017-0445-3) contains supplementary material, which is available to authorized users.

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“…In the first trimester of pregnancy it is used to relieve nausea and to reduce vomiting episodes, while in the last trimester it is used to reduce labor pain. However, chamomile did not relieved labor pain in 33 women during delivery in comparison with placebo [104]. There is no study to support the efficacy of chamomile against nausea and vomiting in early pregnancy, or its relaxant effect during pregnancy.…”

Section: Cranberry (Vaccinium Sp Especially Vaccinium Macrocarponmentioning

confidence: 89%

Herbal Therapy in Pregnancy-What to Expect when you Expect?

Belica

Ćetković

Milić

et al. 2017

Natural Product Communications

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The use of herbal therapy in pregnancy is common for pregnancy related nausea, vomiting, gestational diabetes, anxiety, insomnia, and preparation for labor, as well as for treating infections. Many conventional drugs may interfere with fetal development and herbal products are considered to be safe. However, herbal therapy requires competent healthcare professional advice before prescribing. Knowledge about the possible adverse effects of active compounds of the herbs on pregnancy outcome is limited. Interference of herbal ingredients with conventional medication or the ailment should also not be excluded. For many herbal products, the pharmacological effect is not clinically proven, and the safe usage in pregnancy is not guaranteed. Here, based on published clinical trials, an overview is given of the efficacy and safety for fetal development and pregnancy outcome of the most frequently used herbs: ginger, cranberry, echinacea, mint, chamomile, valerian, flaxseed, tea and raspberry leaf.

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A randomized controlled trial comparing Pentazocine and Chamomilla recutita for labor pain relief

Abstract: Neither Pentazocine, or Chamomilla recutita offer substantial analgesia during labor.

Cited by 14 publications

References 24 publications

Use of Herbal Medicine by Pregnant Women: What Physicians Need to Know

Use of Herbal Medicine by Pregnant Women: What Physicians Need to Know

Randomised, double-blind, placebo-controlled trials of non-individualised homeopathic treatment: systematic review and meta-analysis

Herbal Therapy in Pregnancy-What to Expect when you Expect?

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