A randomized controlled study of the effects of 17Beta-estradiol-dydrogesterone on plasma homocysteine in postmenopausal women

Mijatovic, Velja; Kenemans, P.; Jakobs, Cornelis; Baal, W.M. van; Peters-Muller, E. R. A.; Mooren, M.J. van der

doi:10.1016/s0029-7844(97)00704-7

Cited by 99 publications

(47 citation statements)

References 21 publications

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“…It has been fairly well established that plasma H(e) concentration can be reduced by up to 20% in postmenopausal women who use exogenous estrogen. 34 This could be yet another factor that, in addition to MTHFR genotype and diet, contributes to interindividual variation in plasma H(e) concentration in the present study and in others.…”

Section: Discussionsupporting

confidence: 54%

Plasma Homocyst(e)ine Concentration, But Not MTHFR Genotype, Is Associated With Variation in Carotid Plaque Area

Spence

Malinow

Barnett

et al. 1999

Stroke

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Section: Discussionsupporting

confidence: 54%

Plasma Homocyst(e)ine Concentration, But Not MTHFR Genotype, Is Associated With Variation in Carotid Plaque Area

Spence

Malinow

Barnett

et al. 1999

Stroke

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“…Intact females (n=257) had a mean plasma Hcy concentration of 9.4 ± 0.6 μmol/l (first quartile-median-third quartile 8.5-11.9-16.1 μmol/l, and min-max 2.4-89.5 μmol/l). It has been reported that plasma Hcy concentration tends to increase after menopause in humans, and treatment with 17 β-estradiol-dydrogesterone decreases plasma Hcy concentrations in postmenopausal women (Mijatovic et al, 1998). Trisolini et al, (2008) also reported that the plasma Hcy concentrations were significantly elevated in spayed canines (Trisolini et al, 2008).…”

Section: Sex and Homocysteine Concentrationmentioning

confidence: 98%

“…Men are more commonly affected by HHcy than women because Hcy metabolism is linked to estradiol. Plasma Hcy concentrations also increase with age (Mijatovic et al, 1998). It has been reported that HHcy is related to diseases such as coronary heart disease (Cacciapuoti 2011;Frosst et al, 1995;Humphrey et al, 2008), kidney disease (Friedman et al, 2001), Alzheimer's disease (Moustafa et al, 2012), and rheumatoid arthritis (Roubenoff et al, 1997).…”

Section: Introductionmentioning

confidence: 98%

Plasma Homocysteine Concentrations in Dogs

Kakimoto¹,

Iwanaga²,

Kanouchi³

2014

IJVMR

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Many human epidemiologic studies have reported associations between plasma homocysteine (Hcy) concentrations and cardiovascular disease, Alzheimer's disease, and osteoporosis. However, few studies have examined the relationship between Hcy and disease in dogs. In this study, we investigated the relationship between canine plasma Hcy concentrations and sex, age, breed, size; spay/neuter status, and disease. Plasma Hcy concentrations were related to sex and age, but the correlations were very weak. ShibaInu dogs and Labrador Retrievers had a higher risk of hyperhomocysteinemia than other breeds. We compared the plasma Hcy concentrations of healthy control dogs with those of dogs with heart, inflammatory, bone and joint, nervous system, neoplastic, skin, and kidney diseases. The mean plasma Hcy concentrations of dogs with cardiovascular, neoplasia, skin, and kidney diseases were significantly different from those of controls. However, multivariate logistic regression (parameters: Hcy concentration, age, sex, and spay/neuter status) revealed a significant relationship between only skin disease and plasma Hcy concentration. The odds ratio (per 1 μmol/l increase of Hcy) was 1.077 (95% confidence interval 1.00-1.158, p<0.05). Plasma Hcy concentrations significantly differ among dog breeds, and there is a relationship between high plasma Hcy concentration and skin disease.

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“…In a recent randomized, double-blind, controlled study, a significant 13% reduction in fasting tHcy was obtained by treatment with [38] . This confirms findings of previous, uncontrolled studies.…”

Section: Hormones and Thcymentioning

confidence: 99%

Homocysteine, vitamin status and risk of vascular disease; effects of gender and menopausal status

Verhoef¹,

Meleady²,

Daly³

et al. 1999

European Heart Journal

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Background Elevated plasma total homocysteine (tHcy) is a known risk factor for vascular disease. Gender, age, and circulating levels of folate, vitamins B 6 and B 12 affect tHcy levels.Objectives To study associations of gender and age with levels of plasma tHcy, and to examine the relationships of tHcy and circulating levels of folate, vitamins B 6 and B 12 with risk of vascular disease in men and women (pre-and post-menopausal). Material and methodsIn a multicentre case-control study in Europe, 750 patients (544 men, 206 women) with documented vascular disease of the coronary, cerebral, or peripheral vessels and 800 control subjects (570 men, 230 women) were enrolled. Plasma tHcy levels (fasting and after methionine loading) and circulating levels of the vitamins were measured. Adjustment for age and centre was carried out for all statistical analyses, with additional adjustment for serum creatinine and vitamins for the tHcy comparisons between the sexes and between cases and controls. Risk analyses included adjustment for creatinine and traditional risk factors. Relationships between age, gender and tHcy were studied among control subjects only.Results Fasting tHcy levels were lower in women than in men. Levels of tHcy showed a positive association with age, for both sexes. In the post-menopausal age category, female post-methionine load tHcy levels surpassed levels of men. Elevation of tHcy (defined as >80th percentile of controls) appeared to be at least as strong a risk factor for vascular disease in women as in men, even before the menopause. For post-methionine load tHcy, there was a 40% stronger association with vascular disease in women than in men. In both sexes, but especially in pre-menopausal women, low circulating levels of vitamin B 6 conferred a two-to threefold increased risk of vascular disease, independent of tHcy. In men, but not in women, low (defined as <20th percentile of controls) circulating folate levels were associated with a 50% increased risk of vascular disease. ConclusionsElevation of tHcy appears to be at least as strong a risk for vascular disease in women as men, even before the menopause. Our data indicate that associations of the various tHcy measurements (and the vitamins that determine them), with risks of vascular disease may differ between the sexes. The tHcy-independent relationship of vitamin B 6 with vascular disease indicates that it will be advisable to test the effects of vitamin B 6 in clinical trials. (Eur Heart J 1999; 20: 1234-1244)

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A randomized controlled study of the effects of 17Beta-estradiol-dydrogesterone on plasma homocysteine in postmenopausal women

Abstract: Plasma fasting homocysteine concentrations are lowered by E2-dydrogesterone therapy in postmenopausal women.

Cited by 99 publications

References 21 publications

Plasma Homocyst(e)ine Concentration, But Not MTHFR Genotype, Is Associated With Variation in Carotid Plaque Area

Plasma Homocyst(e)ine Concentration, But Not MTHFR Genotype, Is Associated With Variation in Carotid Plaque Area

Plasma Homocysteine Concentrations in Dogs

Homocysteine, vitamin status and risk of vascular disease; effects of gender and menopausal status

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