A randomized controlled single-blind clinical trial on 84 outpatients with psoriasis vulgaris by auricular therapy combined with optimized Yinxieling Formula (银屑灵优化方)

Lu, Chuanjian; Yu, Xiao Hong; Xie, Xianhe; Xuan, Meiling; He, Zhiyao

doi:10.1007/s11655-012-1020-3

Cited by 36 publications

(39 citation statements)

References 13 publications

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“…The mean effect estimates for these two studies favours herbal medicine in combination with Auricular acupuncture or western medicine Acitretin group. The 95% confidence intervals of Lu et al [49] study are to the right of the line of no treatment effect that show the herbal combing with Auricular therapy is superior than the herbal intervention alone. Zhang et al [51] used herbal medicine combine with Acitretin to compare with herbal medicine alone, the mean effect estimate favours herbal combination therapy, but the 95% confidence intervals overlap 1.…”

Section: Clinical Efficacy Of Herbal Medicinementioning

confidence: 94%

“…A total 13 full text articles were retrieved for further evaluation, 2 were not a randomised controlled trial, 1 was not a herbal intervention. Data were extracted from the remaining 10 [43][44][45][46][47][48][49][50][51][52], Hegazi et al (2013) [52] study was excluded from the meta-analysis because it contains 4 intervention groups and therefore did not meet the inclusion criteria for this review.…”

Section: Findings Study Selectionmentioning

confidence: 99%

“…The 9 RCTs [43][44][45][46][47][48][49][50][51] Three studies, Ahmadi et al [43], Ho et al [46], Lone et al [48], included in the subgroup A meta-analysis ( Figure 2) and listed in the first column "study or subgroup". The individual study findings are displayed in this subgroup meta-analysis with binary outcomes (herbal intervention/placebo control).…”

Section: Clinical Efficacy Of Herbal Medicinementioning

confidence: 99%

“…Two studies, Lu et al [49] and Zhang et al [51] included in the subgroup C meta-analysis (Figure 4). The total number of participants in the herbal intervention groups is 82 and the herbal combine other medication group is 81.…”

Section: Clinical Efficacy Of Herbal Medicinementioning

confidence: 99%

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Current evidence on the effectiveness of systemic herbal medicine for psoriasis: A systematic review with meta-analysis

Tang

Affleck

et al. 2015

Glob Dermatol

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Herbal medicines have been used to treat psoriasis for many years with anecdotal reports of efficacy which have attracted public attention. We seek to assess the effects of systemic herbal medicine in the treatment of psoriasis. Medical database PubMed/MEDLINE, AMED, CINAHL, and CENTRAL were searched. Randomised controlled trials of systemic herbal medicine used in the treatment of psoriasis included in the meta-analysis. Two reviewers independently applied eligibility criteria, assessed the quality of the trials and extracted data. Any discrepancies were discussed with additional reviewer to achieve consensus. Nine randomised controlled trials met the inclusion criteria. The trials randomised 785 participants. Three RCTs revealed that herbal medicine performed better than placebo control (RR=3.98, 1.36-11.62, 95%CI, I2=68%, p=0.01), four RCTs demonstrated that the western drug competitor is superior to herbal medicine(RR=0.73, 0.53-0.97, 95%CI, I2=52%, p=0.03), two RCTs suggested that herbal medicine combined with other medication, (i.e. Auricular Acupuncture or Acitretin (a systemic retinoid), is more effective than herbal medicine alone (RR=1.92, 1.28-2.88, 95%CI, I2=0%, p=0.002). The results of one RCT indicated that herbal medicine reduced the occurrence of adverse reactions of Acitretin, when it was used in combination with herbal medicine. The findings are not conclusive due to the high risk of bias of the included trials and the limited number of trials testing individual herbal medicines. Further well-designed larger scale trials are required to determine the safety and efficacy of oral herbal interventions in the treatment of psoriasis.

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Section: Clinical Efficacy Of Herbal Medicinementioning

confidence: 94%

Section: Findings Study Selectionmentioning

confidence: 99%

Section: Clinical Efficacy Of Herbal Medicinementioning

confidence: 99%

Section: Clinical Efficacy Of Herbal Medicinementioning

confidence: 99%

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Current evidence on the effectiveness of systemic herbal medicine for psoriasis: A systematic review with meta-analysis

Tang

Affleck

et al. 2015

Glob Dermatol

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“…PSORI-CM01 was a novel formulated Chinese medicine used for psoriasis therapy [4]. It was optimized on the basis of a Chinese medicine formula Yin-Xie Ling, which was originated by Guo-Wei Xuan, the State Medical Master of China [5,6].…”

Section: Introductionmentioning

confidence: 99%

Identification and Quantitative Characterization of PSORI-CM01, a Chinese Medicine Formula for Psoriasis Therapy, by Liquid Chromatography Coupled with an LTQ Orbitrap Mass Spectrometer

Chen

Zhao

2015

Molecules

Self Cite

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PSORI-CM01 is a Chinese medicine formula prepared from medicinal herbs and used in China for the treatment of psoriasis. However, the chemical constituents in PSORI-CM01 have not been clarified yet. In order to quickly define the chemical profiles and control the quality of PSORI-CM01 preparations, ultra-high liquid chromatography coupled with electrospray ionization hybrid linear trap quadrupole Orbitrap mass spectrometry (UHPLC-ESI-LTQ/Orbitrap-MS) was applied for simultaneous identification and quantification of multiple constituents. A total of 108 compounds, including organic acids, phenolic acids, flavonoids, and terpenoids, were identified or tentatively deduced on the base of their retention behaviors, MS and MS n data, or by comparing with reference substances and literature data. In addition, an optimized UHPLC-ESI-MS method was established for the quantitative determination of 14 marker compounds in different dosage forms of PSORI-CM01 preparations. The validation of the method, including spike recoveries, linearity, sensitivity (LOQ), precision, and repeatability, was carried out and demonstrated to be satisfied the requirements of quantitative analysis. This is the first report on the comprehensive determination of chemical constituents in PSORI-CM01 preparations by UHPLC-ESI-LTQ/Orbitrap mass spectrometry. The results suggested that the established methods would be a powerful and reliable analytical tool for the

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Yinxieling decoction ameliorates psoriasis by regulating the differentiation and functions of Langerhans cells via the TGF‐β1/PU.1/IL‐23 signal axis

Li,

Ke,

et al. 2024

Cell Biochemistry & Function

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Langerhans cells (LCs) play a critical role in skin immune responses and the development of psoriasis. Yinxieling (YXL) is a representative Chinese herbal medicine for the treatment of psoriasis in South China. It was found to improve psoriasis without obvious side effects in the clinic. Here we attempted to clarify whether and how YXL regulates the differentiation and functions of LCs in Imiquimod (IMQ)‐induced psoriasis in vivo and induced LCs in vitro. The Psoriasis Area Severity Index (PASI) score was used to evaluate the efficacy of YXL for IMQ‐induced psoriasis‐like mice. Flow cytometry was utilized to analyze the effects of YXL, to regulate the differentiation, migration, maturation, and antigen presentation of LCs. The results show that YXL significantly alleviated skin inflammation, as reduced in PASI score and classic psoriasis characteristics in pathological sections. Although there was no effect on the proportion of total DCs in the skin‐draining lymph nodes, the expression of epidermal LCs and its transcription factor PU.1 were both markedly inhibited. LCs were also prevented from migrating from epidermal to skin‐draining lymph nodes and mature. In addition, the number of LCs carrying antigens in the epidermis increased, which suggested that YXL could effectively prevent LCs from presenting antigens. In vitro, YXL had a significant impact on inhibiting the differentiation of LCs. Further data showed that YXL decreased the relative expression of transforming growth factor‐β (TGFβ) messenger RNA (mRNA) and interleukin‐23 (IL‐23) mRNAs. Thus, YXL alleviates psoriasis by regulating differentiation, migration, maturation, and antigen presentation via the TGFβ/PU.1/IL‐23 signal axis.

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A randomized controlled single-blind clinical trial on 84 outpatients with psoriasis vulgaris by auricular therapy combined with optimized Yinxieling Formula (银屑灵优化方)

Abstract: The therapeutic effect of auricular therapy combined with Optimized Yinxieling Formula was superior to Optimized Yinxieling Formula alone with no obvious adverse reaction.

Cited by 36 publications

References 13 publications

Current evidence on the effectiveness of systemic herbal medicine for psoriasis: A systematic review with meta-analysis

Current evidence on the effectiveness of systemic herbal medicine for psoriasis: A systematic review with meta-analysis

Identification and Quantitative Characterization of PSORI-CM01, a Chinese Medicine Formula for Psoriasis Therapy, by Liquid Chromatography Coupled with an LTQ Orbitrap Mass Spectrometer

Yinxieling decoction ameliorates psoriasis by regulating the differentiation and functions of Langerhans cells via the TGF‐β1/PU.1/IL‐23 signal axis

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