A randomized, controlled, double-blinded and double-dummy trial of the effect of Tongjiang Granule (通降颗粒) on the nonerosive reflux disease of and Gan (肝)-Wei (胃) incoordination syndrome

Li, Bao-Shuang; Li, Zhenhua; Tang, Xudong; Zhang, Liying; Zhao, Yong; Bian, Li-Qun; Zhang, Yinqiang; Wang, Ping; Wang, Fengyun

doi:10.1007/s11655-011-0724-0

Cited by 13 publications

(18 citation statements)

References 3 publications

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“…Currently, it has become a common model in the diagnosis and treatment of TCM clinical practice [26]. The mode of disease-syndrome combination has been successfully and widely applied to a variety of clinical diseases including restenosis after percutaneous coronary intervention [27], unstable angina [28], cancer [29], nonerosive reflux disease [30], rheumatoid arthritis [31], posthepatitis B liver cirrhosis [32], liver fibrosis [33], poststroke dysphagia [34], menopausal symptoms [35], and psoriasis vulgaris [36]. …”

Section: Disease-syndrome Combination Is a New Mode For Treatment mentioning

confidence: 99%

Trends in the Treatment of Hypertension from the Perspective of Traditional Chinese Medicine

Xiong

Yang

Liu

et al. 2013

Evidence-Based Complementary and Alternative Medicine

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Hypertension is a major public-health issue. Much consensus has been reached in the treatment, and considerable progress has been made in the field of antihypertensive drugs. However, the standard-reaching rate of blood pressure is far from satisfaction. Considering these data and the seriousness of the effects of hypertension on the individual and society as a whole, both economically and socially, physicians must look for more effective and alternative ways to achieve the target blood pressure. Could treatment of hypertension be improved by insights from traditional Chinese medicine? As one of the most important parts in complementary and alternative therapies, TCM is regularly advocated for lowering elevated blood pressure. Due to the different understanding of the pathogenesis of hypertension between ancient and modern times, new understanding and treatment of hypertension need to be reexplored. Aiming to improve the efficacy of Chinese herbal medicine in treating hypertension, the basis of treatment is explored through systematically analyzing the literature available in both English and Chinese search engines. This paper systematically reviews the trends in emerging therapeutic strategies for hypertension from the perspective of traditional Chinese medicine.

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Section: Disease-syndrome Combination Is a New Mode For Treatment mentioning

confidence: 99%

Trends in the Treatment of Hypertension from the Perspective of Traditional Chinese Medicine

Xiong

Yang

Liu

et al. 2013

Evidence-Based Complementary and Alternative Medicine

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“…The randomized methods were described in detail in all studies [ 9 – 22 ], which were considered as randomized blocks [ 13 ], sealed envelopes [ 12 , 14 , 20 ], and random number tables [ 9 , 10 , 14 – 19 , 21 , 22 ]. Hence, we considered them low risk in the aspect of selection bias.…”

Section: Resultsmentioning

confidence: 99%

“…Hence, we considered them low risk in the aspect of selection bias. Almost none of the studies reported blinded methods, which were regarded as high risk in terms of performance bias except for the study reported by Li et al [ 13 ]. Detection bias was low risk in two studies [ 13 , 14 ], but it was unclear in other studies [ 9 – 12 , 15 – 22 ] in the absence of the blinding of outcomes assessment.…”

Section: Resultsmentioning

confidence: 99%

“…Almost none of the studies reported blinded methods, which were regarded as high risk in terms of performance bias except for the study reported by Li et al [ 13 ]. Detection bias was low risk in two studies [ 13 , 14 ], but it was unclear in other studies [ 9 – 12 , 15 – 22 ] in the absence of the blinding of outcomes assessment. In all studies, fewer than 10% of participants dropped out or were lost to follow-up, which was deemed to be low risk in the matter of incomplete outcome data.…”

Section: Resultsmentioning

confidence: 99%

“…In all studies, fewer than 10% of participants dropped out or were lost to follow-up, which was deemed to be low risk in the matter of incomplete outcome data. One study [ 19 ] selectively reported partial follow-up cases due to lack of research time, which was considered high risk; four studies [ 11 , 12 , 18 , 21 ] were unclear, and other studies [ 9 , 10 , 13 – 17 , 20 , 22 ] were low risk. Meanwhile, the risks of these studies were unclear in other biases ( Figure 2 ).…”

Section: Resultsmentioning

confidence: 99%

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Efficacy and Safety of Traditional Chinese Medicine on Nonerosive Reflux Disease: A Meta‐Analysis of Randomized Controlled Trials

Xiao

Yang²,

Zhu³

et al. 2018

Evidence-Based Complementary and Alternative Medicine

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Objectives Traditional Chinese medicine (TCM) therapy for nonerosive reflux disease (NERD) remains controversial. The aim of this study was to evaluate the efficacy and safety of TCM regimens in NERD treatment. Methods Randomized controlled trials (RCTs) of TCM treatment for NERD through September 31, 2017, were systematically identified in PubMed, Wanfang Data, CNKI, VIP, CBM, Ovid, Web of Science, and Cochrane Library databases. Quality assessment was performed by employing the Cochrane Risk of Bias assessment tool. Results A total of 725 and 719 patients in 14 RCTs were randomly divided into TCM alone and conventional Western medicine groups, respectively. The clinical total effective rate of the TCM group was markedly higher than that of the single proton pump inhibitors (PPIs) or Prokinetics therapy group (RR = 1.19, 95% CI = 1.07–1.31, and P = 0.0008), while it was comparable to that of the combination of PPIs and Prokinetics therapy group (RR = 1.14, 95% CI = 1.00–1.29, and P = 0.05). Compared with Western medicine group, the TCM group showed improved symptom relief through a reduced RDQ score (SMD = −0.91; 95% CI = −1.68–−0.15; and P = 0.02). Additionally, TCM clearly decreased the recurrence rate (RR = 0.38, 95% CI = 0.28–0.52, and P < 0.00001). Adverse events, such as constipation, sickness, fever, abdominal distension, and stomach noise, were slight for both the TCM and Western medicine groups and disappeared after the easement of pharmacological intervention; in particular, TCM possessed fewer side effects. Conclusion Compared with PPIs or Prokinetics therapy alone, TCM single therapy can better improve the clinical total effective rate and symptom relief and decrease the recurrence rate and adverse events in the treatment of NERD. Our results suggest that TCM will be a promising alternative therapy for NERD patients in the future.

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Endorsement of CONSORT by Chinese medical journals: A survey of “instruction to authors”

Xiao

Zhang

et al. 2014

Chin. J. Integr. Med.

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A randomized, controlled, double-blinded and double-dummy trial of the effect of Tongjiang Granule (通降颗粒) on the nonerosive reflux disease of and Gan (肝)-Wei (胃) incoordination syndrome

Abstract: TJG showed a definite effect on the treatment of NERD with Gan-Wei incoordination syndrome, and it could improve the quality of life of NERD patient without obvious toxic and side effects.

Cited by 13 publications

References 3 publications

Trends in the Treatment of Hypertension from the Perspective of Traditional Chinese Medicine

Trends in the Treatment of Hypertension from the Perspective of Traditional Chinese Medicine

Efficacy and Safety of Traditional Chinese Medicine on Nonerosive Reflux Disease: A Meta‐Analysis of Randomized Controlled Trials

Endorsement of CONSORT by Chinese medical journals: A survey of “instruction to authors”

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