A randomized control trial of a supervised versus a self‐directed exercise program for allogeneic stem cell transplant patients

Shelton, Margarette L.; Lee, Jeannette Q.; Morris, Gerwyn; Massey, P; Kendall, Deborah G.; Munsell, Mark F.; Anderson, Karen O.; Simmonds, Maureen J.; Giralt, Sergío

doi:10.1002/pon.1505

Cited by 75 publications

(85 citation statements)

References 28 publications

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“…19,20 The 6-min walk test is a submaximal performance test that reflects the tasks of daily living and has previously been used in hematological cancer populations. 3,9 Patients were advised to walk back and forth down a hallway as fast as possible for 6 min. The 6-min walk distance (6MWD) was assessed in meters (m).…”

Section: Discussionmentioning

confidence: 99%

“…7 Since this review, six new randomized controlled trials have been published, supporting these findings; some studies showed strong effects for body composition as well as weaker but promising effects for cardiorespiratory fitness, fatigue, muscle strength, physical functioning and quality of life. [8][9][10][11][12][13] Nevertheless, many questions remain unanswered regarding exercise interventions in HCT patients. Additional evidence is required to determine the optimal exercise recommendation, with respect to amount, type, intensity and time point for intervention.…”

Section: Introductionmentioning

confidence: 99%

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Efficacy of exercise training in SCT patients-who benefits most?

Wiskemann

Kuehl

Dreger

et al. 2013

Bone Marrow Transplant

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Patients undergoing allo-HCT often experience a substantial loss in physical performance. We have recently published the general effectiveness of an exercise intervention in 105 allo-HCT patients on physical performance and psychosocial well-being. However, predictor variables for differentiated treatment response remained unclear. To determine the impact of basic physical performance on treatment response, we assessed muscle strength and endurance performance at four assessment points before and after allo-HCT. The exercise group started training 2 weeks before admission and ended 6-8 weeks after discharge. Comparing initially fit with unfit classified patients, the fit patients lost 31% of the strength of the knee-extensors, whereas the unfit patients lost only 1% (Po0.05). For endurance capacity, fit patients lost 4% of their walking capability, whereas unfit patients gained 13% (Po0.05). The individual percent change was statistically different at the 0.05 level in all measures of physical performance. Individual training response in allo-HCT patients strongly depends on the initial physical performance level. Unfit patients can be trained safely and may benefit more from this exercise intervention than fit patients. This result is of major clinical relevance and should encourage hematologists to promote exercise even more in impaired/unfit allo-HCT patients.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Efficacy of exercise training in SCT patients-who benefits most?

Wiskemann

Kuehl

Dreger

et al. 2013

Bone Marrow Transplant

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“…We located 17 publications from 13 studies, 39,40,52-66 8 of which 39,40,53,54,56,[63][64][65] were RCTs. Only two included a large population sample (nX100).…”

Section: Adultsmentioning

confidence: 99%

Exercise in adult and pediatric hematological cancer survivors: an intervention review

et al. 2010

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Observational research has shown that the physical activity levels of survivors of hematological cancer are low, with deleterious health consequences. This review summarizes the research on exercise interventions in adult and pediatric hematological cancer survivors. We searched MEDLINE, SPORTDiscus, CINAHL, Embase, Cochrane and PEDro through September 2009 for exercise intervention studies in children and adults with any type of hematological cancer. In the 24 adult intervention studies reviewed, we found strong evidence (that is, X3 high-quality studies and X75% reporting a significant benefit) for a benefit on body composition. Weak, but promising, evidence (X3 high-quality studies, but o75% reporting a significant benefit) was found for cardiorespiratory fitness, fatigue, muscle strength, physical functioning and quality of life. In pediatric interventions (13 studies), we found strong evidence for a benefit on muscle strength and cardiorespiratory fitness, particularly, if training was conducted in the hospital setting. Evidence is weak for ankle dorsiflexion, physical functioning and body composition. No exerciserelated risks were identified in adults or children studies. Though more randomized controlled trials are needed, a growing body of literature supports the notion that regular physical activity is safe and has potential benefits for both adult and pediatric hematological cancer survivors.

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“…Furthermore, maintaining some degree of physical activity attenuates the loss of, and can even improve, functional capacity PAGAC, 2008;Segal et al, 2003). Intervention studies with breast cancer survivors have demonstrated that physical activity can significantly decrease fatigue, both during treatment Mock et al, 2005;Pinto et al, 2000) and after treatment (Burnham & Wilcox, 2003;Granger et al, 2011;Shelton et al, 2009;Wilson et al, 2005). There have been fewer studies conducted with nonbreast cancer survivors, although there is some evidence that physical activity also reduces CRF in other cancer survivors, notably those with prostate cancer (Battaglini, 2011;Cramp & Daniel, 2008;Fong et al, 2012;Keogh & MacLeod, 2012;Monga et al, 2007).…”

Section: Physical Healthmentioning

confidence: 99%

“…For example, Shelton et al (2009) conducted an intervention study with haematological cancer survivors comparing supervised with self-directed groups, and found that the supervised group showed a greater decrease in fatigue, although this difference was not statistically significant. Additionally, a meta-analysis of RCTs reported that supervised aerobic programmes were significantly more successful in reducing CRF than home-based aerobic programmes in breast cancer survivors during treatment (Velthius et al, 2010), although there were not enough studies with prostate cancer survivors to draw conclusions for this population.…”

Section: Supervised Versus Self-directedmentioning

confidence: 99%

Physical Activity and Cancer

Bk¹,

Ih²,

Rohde³

2013

Encyclopedia of Behavioral Medicine

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It is widely accepted that physical activity is important for physical functioning and well-being, and as such the promotion of active lifestyles is becoming increasingly significant in public health policy both in the UK and worldwide. Sedentary lifestyles have been associated with increased risk of obesity and preventable disease including diabetes, coronary heart disease and some cancers. With regards cancer specifically, this chapter will provide a brief overview on current opinions on the link between physical activity and cancer prevention.The published evidence focuses both on primary and secondary prevention. More recent evidence has investigated the use of physical activity in secondary prevention for those who have been diagnosed with cancer and proposed a link between physical activity, morbidity and mortality in those with cancer. The evidence-base for secondary prevention is more limited. Nevertheless, studies to date have indicated that physical activity can improve both physical functioning and psychological outcomes in cancer survivors, and significantly improve quality of life.The exact nature of those interventions which confer the most positive effects is less well-established, and there is a current lack of consensus on the most appropriate type, intensity and duration of activity for people with cancer. It has not yet been wellestablished as to which stage of the treatment programme physical activity should be encouraged (during or following treatment) or the most appropriate length of time during which structured physical activity interventions should be delivered to achieve beneficial results.These factors will be discussed in this chapter, and barriers to engaging in physical activity for those with a diagnosis of cancer will be considered. The chapter will conclude with a summary of key findings and the potential for further research.

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A randomized control trial of a supervised versus a self‐directed exercise program for allogeneic stem cell transplant patients

Cited by 75 publications

References 28 publications

Efficacy of exercise training in SCT patients-who benefits most?

Efficacy of exercise training in SCT patients-who benefits most?

Exercise in adult and pediatric hematological cancer survivors: an intervention review

Physical Activity and Cancer

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