A randomized comparison of vaginal misoprostol and dinoprostone for cervical priming in nulliparous women before operative hysteroscopy

Sublingual misoprostol for cervical ripening before diagnostic hysteroscopy in premenopausal women: A randomized, double blind, placebo-controlled trial

“…In the misoprostol group, 55 patients (n¼73) needed cervical dilatation, compared with 75 (P¼.001) in the placebo group (n ¼ 79). The median time of cervical dilatation to Hegar number 9 was significantly shorter in the treated group (40 seconds) compared with the control group (120 seconds) (11).…”

“…Preutthipan and Herabutya studied the effectiveness of 200 mg vaginal misoprostol for cervical priming that was placed in the posterior vaginal fornix 9-10 hours before operative hysteroscopy among premenopausal women who were nulliparous in a randomized controlled trial (11). In the misoprostol group, 55 patients (n¼73) needed cervical dilatation, compared with 75 (P¼.001) in the placebo group (n ¼ 79).…”

A Multi-Center Prospective, Randomized, Double-Blind Trial Studying the Effect of Misoprostol on the Outcome of Intrauterine Insemination

“…It has been extensively studied in reproductive health. The best known effect of PG in gynecologyobstetrics are myometrial contractions [11,12] . Significant differences in the pharmacokinetics of misoprostol and uterine contractility were seen in relation to the mode of administration.…”

218: Comparison of Self-administered Vaginal Misoprostol Versus Placebo for Cervical Ripening Prior to Operative Hysteroscopy Using a Sequential Trial Design

“…[11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28] Most of the studies have separately, but not systematically, compared the effect on different groups of women, such as nulliparous women and postmenopausal women. Eight of the studies included less than 50 women, 12,13,16,18,[20][21][22]25 four did not compare the effect of misoprostol with a placebo, [23][24][25]27 and ten of the trials appear to be underpowered or lacking a sample size calculation as regards to evaluating primary outcome measures. [11][12][13][16][17][18][20][21][22]26 It appears that none of the trials has been designed and conducted in accordance with the CONSORT statement.…”

“…[12][13][14][15][16][17][19][20][21][22][23][24][25][26][27] Less commonly, preoperative ripening is assessed by measuring cumulative dilatation force using a cervical tonometer. 11,13,16 Cervical resistance to dilatation or complications encountered during the procedure are also parameters that can indicate effectiveness of cervical ripening.…”