A randomized comparison of medical abortion and surgical vacuum aspiration at 10-13 weeks gestation

Abstract

Medical abortion is safe and effective at 10-13 weeks gestation and should be considered an option for those women who wish to avoid surgery and anaesthesia.

Alternatives to routine ultrasound for eligibility assessment prior to early termination of pregnancy with mifepristone-misoprostol

“…Studies have explored the effectiveness of medical termination of pregnancy after 10 weeks from LMP, and have demonstrated the efficacy and acceptability of regimens of mifepristone and misoprostol. [5][6][7][8][9] Most protocols used for gestational ages above 63 days from LMP require 800 lg vaginal misoprostol in an in-clinic setting, 24-48 hours after the administration of 200 mg mifepristone, with an additional 400 lg vaginal, oral or sublingual misoprostol administered every 3 hours. As clinical research shows, the effectiveness of termination of pregnancy with mifepristone-misoprostol does not suddenly cease at 64 days of pregnancy.…”

“…Termination of pregnancy with mifepristonemisoprostol is also used in the late first trimester (10)(11)(12) weeks from LMP) with documented success rates after 9 weeks from LMP being comparable with those achieved at earlier gestations, with some modifications in the protocol. [5][6][7][8][9][10] Previous research has indicated a high correlation between pregnancy dating determined by clinician (based on bimanual examination and history) and that determined by sonography. 11 Women who have a clear idea of the date of their LMP tend, on average, to believe that their pregnancies are slightly more advanced than they are.…”

Is it time to move up? Feasibility of medical abortion between 9-13 weeks of gestation

“…Our study shows also efficacy of medical and surgical method is comparable with no statistically significant difference. 8 Efficacy of medical method is 95% in our study which makes medical abortion in later first trimester an effective alternative of surgical method of abortion. Schaff and colleagues also showed no difference in efficacy in relation to gestation, with medical abortion being highly acceptable (91%).…”

“…This is different from our study reason being we have given the treatment according to patient's preference. 8 According to ashok et al, medical abortion is as safe and effective as vacuum aspiration at 10-13 weeks gestation. Our study shows also efficacy of medical and surgical method is comparable with no statistically significant difference.…”

Medical Abortion: Use of Mifepristone and Misoprostol in First and Second Trimesters of Pregnancy

“…More often, late first-trimester MA up to 13 weeks gestation occurs in an inpatient setting with repeated doses of misoprostol until passage of the pregnancy tissue. Failure rates increase with gestational age, as do the number of doses of misoprostol required, time from induction to abortion, risk of needing a surgical procedure, and risk of needing a blood transfusion [43][44][45][46]. Despite these findings, the procedure remains safe with a success rate above 90 %, and patients report it to be a desirable option [41•, 42••, 43-48].…”