A Randomized Comparative Trial on the Therapeutic Efficacy of TopicalAloe veraandCalendula officinalison Diaper Dermatitis in Children

Abstract

Introduction. Diaper dermatitis (DD) is a common inflammatory disorder among children and infants. The objective of the present randomized and double-blind trial was to compare the therapeutic efficacies of Aloe vera cream and Calendula officinalis ointment on the frequency and severity of DD in children. Methods. Sixty-six infants with DD (aged < 3 years) were randomized to receive either Aloe cream (n = 32) or Calendula ointment (n = 34). Infants were treated with these drugs 3 times a day for 10 days. The severity of dermatitis was graded at baseline as well as at the end of trial using a 5-point scale. The adverse effects of study medications were assessed during the trial. Results. Although improvement in the severity of DD was observed in both treatment groups (P < 0.001), patients receiving Calendula ointment had significantly fewer rash sites compared to Aloe group (P = 0.001). No adverse effect was reported from either of the medications. Discussion. The evidence from this study suggests that topical Aloe and in particular Calendula could serve as safe and effective treatment for the treatment of diaper dermatitis in infants.

Evaluation of clinical effectiveness of Aloe vera – a review

“…There was no adverse effects from the study drug. Consequently, the results of these experiments show that topical application of Aloe vera gel can be used as a safe and well-functioning nappy dermatitis therapy [13]. These beneficial effects could be attributed to the well-known antiinflammatory properties of Aloe vera [14].…”

“…Plaque psoriasis reduces score sum of erythema, infiltration and desquamation causes only local side-effects [12] Nappy dermatitis decreases severity of nappy dermatitis reduces rash does not cause any adverse effect [13] Vulval lichen planus results in a good response in patients with vulval lichen planus located on labia minora does not cause side-effects [16] Dry skin increases facial skin hydration levels increases arm skin hydration reduces wrinkle depth improves skin quality does not cause any adverse reactions improves skin integrity decreases appearance of fine wrinkling decreases erythema [18] [19]…”

Main ingredients in herbal formulation may act as preservative agent

“…The healing properties, anti-inflammatory action, moisturizing and anti-aging effect of Aloe vera gel have been explored (Hashemi et al, 2015;Surjushe et al, 2008). The safe application and therapeutic efficacy of Calendula officinalis ointment and A. vera cream were shown in treatment of diaper dermatitis in infants (Panahi et al, 2012).…”

Shampoo-Clay Heals Diaper Rash Faster Than Calendula Officinalis

“…Calendula officinalis (C.O) may also be effective in non-complicated cases (12). C.O has antiseptic and anti-inflammatory properties (13).…”