A randomized clinical trial of comprehensive education and care program compared to basic care for reducing anxiety and depression and improving quality of life and survival in patients with hepatocellular carcinoma who underwent surgery

Wang, Jingjing; Yan, Chenli; Fu, Adan

doi:10.1097/md.0000000000017552

Cited by 26 publications

(28 citation statements)

References 25 publications

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“…Input parameters varied widely between surgeries (Figure 2). Appendix A presents all input parameters, their sources 26,27,36–45,28,46–55,29,56–65,30,66–75,31,76–82,32–35 , and the corresponding model output for each semi-elective surgery.…”

Section: Resultsmentioning

confidence: 99%

Minimizing Population Health Loss in Times of Scarce Surgical Capacity

Gravesteijn¹,

Krijkamp

Busschbach

et al. 2020

Preprint

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Background COVID-19 has put unprecedented pressure on healthcare systems worldwide, leading to a reduction of the available healthcare capacity. Our objective was to develop a decision model that supports prioritization of care from a utilitarian perspective, which is to minimize population health loss. Methods A cohort state-transition model was developed and applied to 43 semi-elective non-paediatric surgeries commonly performed in academic hospitals. Scenarios of delaying surgery from two weeks were compared with delaying up to one year, and no surgery at all. Model parameters were based on registries, scientific literature, and the World Health Organization global burden of disease study. For each surgery, the urgency was estimated as the average expected loss of Quality-Adjusted Life-Years (QALYs) per month. Results Given the best available evidence, the two most urgent surgeries were bypass surgery for Fontaine III/IV peripheral arterial disease (0.23 QALY loss/month, 95%-CI: 0.09-0.24) and transaortic valve implantation (0.15 QALY loss/month, 95%-CI: 0.09-0.24). The two least urgent surgeries were placing a shunt for dialysis (0.01, 95%-CI: 0.005-0.01) and thyroid carcinoma resection (0.01, 95%-CI: 0.01-0.02): these surgeries were associated with a limited amount of health lost on the waiting list. Conclusion Expected health loss due to surgical delay can be objectively calculated with our decision model based on best available evidence, which can guide prioritization of surgeries to minimize population health loss in times of scarcity. This tool should yet be placed in the context of different ethical perspectives and combined with capacity management tools to facilitate large-scale implementation.

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Section: Resultsmentioning

confidence: 99%

Minimizing Population Health Loss in Times of Scarce Surgical Capacity

Gravesteijn¹,

Krijkamp

Busschbach

et al. 2020

Preprint

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“…[ 9 ] In addition, most patients with HCC also suffer from depression disorder. [ 11 ] Although several managements can help relieve psychological disorder and improve QoL in patients with HCC, [ 18 , 20 , 21 , 23 ] it is not always effective for some patients. Therefore, therapies that could significantly improve psychological health condition and living quality are what we need to pursue now.…”

Section: Discussionmentioning

confidence: 99%

“…Even though there was statistical analysis of published clinical trials, [ 18 – 23 ] the exact therapeutic effects of HQNC on psychological disorders and QoL in patients with HCC were remains controversial. This systematic review will provide a helpful evidence for clinicians to formulate the best treatment strategy for HCC patients with psychological disorder and poor QoL, and also provide scientific clues for researchers in this field.…”

Section: Discussionmentioning

confidence: 99%

“…High quality nursing care (HQNC) has been reported to effectively prevent psychological disorders and improve the QoL in patients with HCC in several studies. [ 18 – 23 ] Unfortunately, no study has systematically assessed these effects of HQNC for HCC. Therefore, in this study, we will systematically evaluate the preventive effect of HQNC on psychological disorders, and the improvement effect of HQNC on QoL in patient with HCC through the meta-analysis, in order to provide scientific reference for the design of future clinical trials (Work flow of the present study, Fig.…”

Section: Introductionmentioning

confidence: 99%

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Effects of high-quality nursing care on psychological outcomes and quality of life in patients with hepatocellular carcinoma

Zhang

Cui³

et al. 2020

Medicine

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Background: High quality nursing care (HQNC) has been reported to effectively prevent psychological disorders and improve the quality of life (QoL) in patients with hepatocellular carcinoma (HCC) during the treatment. However, the exact effect of HQNC remains controversial. This systematic review will be aimed to assess the effectiveness of HQNC on psychological disorders and QoL in patients with HCC. Methods: Eligible prospective controlled clinical trials were searched from Google Scholar, Medline, Excerpt Medica Database (Embase), PubMed, Web of Science (WOS), Cochrane Library, China Scientific Journal Database (CSJD), China National Knowledge Infrastructure (CNKI), Chinese BioMedical Database (CBM) and Wanfang Database. Papers in English or Chinese published from January 2000 to July 2020 will be included without any restrictions. The clinical outcomes including psychological outcomes, QoL, and adverse events of HQNC in patients with HCC were systematically evaluated. Study selection and data extraction will be performed independently by two reviewers. Stata 14.0 and Review Manager 5.3 were used for data analysis. Methodological quality for each eligible study will be assessed by using Cochrane risk of bias tool. Subgroup and meta-regression analysis will be carried out depending on the availability of sufficient data. Results: The results of this systematic review will be published in a peer-reviewed journal. Conclusion: The results of this study may provide helpful evidence of HQNC on psychological effects and QoL in patients with HCC. INPLASY registration number: INPLASY202070096.

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“…Hepatocellular carcinoma (HCC) is a leading cause of cancer-related deaths in the world 1 . Chemotherapy is one of the most common treatment methods for patients with advanced HCC 2 . Although therapeutic strategies, including resection, liver transplantation, image-guided tumor ablation, and transcatheter chemoembolization, have been developed to combat liver cancer, the clinical outcomes remain unsatisfactory due to a lack of sensitive and specific biomarkers for early diagnosis 3,4 .…”

Section: Introductionmentioning

confidence: 99%

miR-202 Suppresses Hepatocellular Carcinoma Progression via Downregulating BCL2 Expression

Zhuang

Zhang

et al. 2020

oncol res

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MiRNAs play an important role in progression of hepatocellular carcinoma (HCC). In this work, we assessed the function of miR-202 in human HCC and identified BCL2 as its target. We found miR-202 expression was found significantly downregulated, while BCL2 expression was markedly upregulated in HCC tissues and cell lines (HepG2, Hep3B and HCCLM3). Both miR-202 and BCL2 were closely correlated with major vascular invasion and advanced TNM stage as well as overall survival (OS) of HCC patients. Overexpression of miR-202 significantly inhibited cell proliferation, induced apoptosis and cell cycle arrest at G0/G1 phase, and prevented tumor formation in a xenograft nude mouse model. Further, miR-202 dramatically inhibited migration, invasion and epithelial-mesenchymal transition (EMT). MiR-202 bound to the 3ʹ-untranslated region (3'-UTR) of BCL2 mRNA, and downregulated the expression level of BCL2 protein. Exogenous BCL2 over-expression weakened the inhibitory effects of miR-202, while inhibition of BCL2 enhanced the inhibitory effects of miR-202. In conclusion, miR-202 serves as a tumor suppressor in HCC progression by downregulating BCL2 expression, indicating miR-202 might be as a potential target for HCC.

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A randomized clinical trial of comprehensive education and care program compared to basic care for reducing anxiety and depression and improving quality of life and survival in patients with hepatocellular carcinoma who underwent surgery

Cited by 26 publications

References 25 publications

Minimizing Population Health Loss in Times of Scarce Surgical Capacity

Minimizing Population Health Loss in Times of Scarce Surgical Capacity

Effects of high-quality nursing care on psychological outcomes and quality of life in patients with hepatocellular carcinoma

miR-202 Suppresses Hepatocellular Carcinoma Progression via Downregulating BCL2 Expression

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