A randomized clinical trial for comparing the efficacy of desensitizing toothpastes on the relief of dentin hypersensitivity

Abstract

The 4-week double-blind clinical trial to manage dentin hypersensitivity (DH) using different desensitizing toothpastes was conducted. 53 participants with DH were enrolled in this trial. The participants were randomized into 3 groups: Group N; no active ingredient-containing toothpaste (Pleasia fluoride-free), Group SC; a toothpaste containing strontium chloride (Sensodyne Original), and Group TP; a toothpaste containing tricalcium phosphate (Vussen S). They were instructed to brush their teeth manually for 3 min, 3 times per day for 4 weeks with the allocated toothpastes, and were assessed at baseline (0), 2, and 4 weeks, respectively. Schiff sensitivity score was recorded to 3 different stimuli (air-blast, cold, and acid) at each assessment. Overall DH was also assessed using a visual analog scale (VAS). The longer participants used the toothpastes, the greater reduction in DH in all groups to the three stimuli. Group TP demonstrated significant reduction of DH compared to group N for air-blast and cold stimuli. Group TP showed significantly lower VAS than group N and SC. Tricalcium phosphate containing toothpaste used in this trial was most useful to reduce DH. It can be one of the treatment options that alleviate DH.

Investigating Bioactive-Glass-Infused Gels for Enamel Remineralization: An In Vitro Study

“…Dionysopoulos et al [7] review contemporary therapeutic approaches to dentin hypersensitivity, emphasizing the long-term benefits of tubule occlusion, particularly through the use of bioactive materials like calcium phosphate and nano-hydroxyapatite. This occlusion can be achieved with various ions, such as strontium or calcium ions and phosphate anions [8]. These substances are found in materials like amorphous calcium phosphate (ACP), tricalcium phosphate (TCP), nano-hydroxyapatite (nHA), bioactive glasses, among others.…”

“…In the case of these materials, their size and potential criticality are very important, as they may affect the ability to deliver ions and the depth of ion penetration into the lesion. For this reason, different products have different mineralization effects [8,9]. Research has demonstrated the capacity of bioactive glass not only to deliver critical ions for remineralization but also to initiate the formation of hydroxy carbonate apatite (HCA), which closely resembles the mineral composition of natural teeth.…”

“…Research has demonstrated the capacity of bioactive glass not only to deliver critical ions for remineralization but also to initiate the formation of hydroxy carbonate apatite (HCA), which closely resembles the mineral composition of natural teeth. This effect is pivotal for the in vitro remineralization of dental enamel, as detailed in studies exploring the interaction of bioactive glasses with human dental tissues [8,10,11].…”

Dentin Hypersensitivity: Etiology, Diagnosis and Contemporary Therapeutic Approaches—A Review in Literature

“…Despite the numerous methods proposed for treating DH, a definitive solution to the issue has yet to be identified. Clinical studies evaluating the efficacy of different treatment approaches yield contradictory results [10][11][12]. This discrepancy stems from the fact that all these studies assess pain intensity, a parameter that proves notably challenging to evaluate due to its inherently subjective and intricate nature [13].…”