A Randomized, Clinical Trial Comparing Oral Celecoxib 200 mg, Celecoxib 400 mg, and Ibuprofen 600 mg for Acute Pain

Abstract

Objective: Celecoxib is a selective cyclooxygenase-2 (COX-2) inhibitor used to treat pain. The objective of this study was to compare the efficacies of celecoxib and ibuprofen for the treatment of acute pain. The null hypothesis was that no difference between celecoxib and ibuprofen exists. Methods: The study was a prospective, randomized, double-blind, controlled clinical trial. After consent, patients rated their pain on a 100-mm visual analog scale (VAS) and categorical intensity pain scale. Patients were then randomized to receive 200-mg or 400-mg celecoxib or 600-mg ibuprofen (all orally). Patients were contacted 5 hours after receiving study medication when a second VAS score was recorded, along with categorical pain intensity, pain relief score, side effects, and number of rescue medications taken. The main outcome measures were change in visual analog pain and categorical pain intensity scores, and pain relief scores, at five hours. Results: One hundred ten patients were evaluated and 105 were enrolled. Thirty-four received celecoxib 200 mg, 32 received celecoxib 400 mg, and 39 received ibuprofen 600 mg. Ninety-one were available for the five-hour VAS and 88 for the five-hour categorical pain intensity and pain relief analysis: The two patients who were unable to read a VAS were excluded, and two enrolled patients withdrew prior to medication. One patient was excluded because his injury was a fracture, and therefore did not meet the inclusion criteria. There was no statistical difference among the treatment groups in age, time from injury to medication, initial VAS score, percent lost to follow-up, or treatment with adjunctive therapy. There was no statistical difference in change of VAS among the groups at five hours: ibuprofen 600 mg (Ϫ23. There was no significant difference between the groups, at five hours, in change of categorical pain intensity (p = 0.11) or pain relief scores (p = 0.059), though the pain relief scale approached significance favoring ibuprofen. Conclusions: No significant difference exists among emergency department (ED) patients treated for acute pain, at five hours, with celecoxib 200 mg, celecoxib 400 mg, or ibuprofen 600 mg, though the power of the study to detect a change was low, 36%. However, the magnitude of pain relief for celecoxib, coupled with the cost of the medication, questions its use in the immediate ED setting.

A Pre-Post Study on Efficacy of Celecoxib and Ibuprofen for Acute Low Back Pain among Orthopaedic Patients at Security Forces Hospital, Makkah, Saudi Arabia

“…Further analysis comparing the two study groups indicated that celecoxib was more effective when compared to ibuprofen. This finding is contrast from a study by Salo et al [15] No significant difference was found in their study when compared between celecoxib and ibuprofen among patients with acute pain in the emergency department. Van Tulder et al noted that Ibuprofen is highly recommended than other NSAIDs because of its lower cost and GIT side-effects.…”

Effectiveness of Nsaids for Pain Management in Periodontal Surgery

“…The non-selective COX-2 inhibitor Ibuprofen ® acts mainly on the quinine and histamine systems, which have a proven role in inflammatory processes [16,17]. Ibuprofen ® is rapidly absorbed after oral administration and shows high plasma concentration levels 2 hours after the first dose [10,18]. It is considered an appropriate tool for long-term analgesic therapy.…”

“…NSAIDs according to their ability to inhibit the enzyme cyclooxygenase (COX-1 and 2) are: highly selective NSAIDs (COX-2 inhibitors) -Rofecoxib, Etodolac, Meloxicam, Nimesulid, Celecoxib; NSAIDs with lower COX selectivity -Diclofenac, Piroxicam, and NSAIDs with low COX selectivity -salicylates [14,15]. These drugs successfully suppress the mediators of inflammationmainly prostaglandins (PG), which are important for the occurrence of inflammation and pain: Ibuprofen, Etodolac, Ketoprofen, Ketorolac, Flurbiprofen, Tenoxicam, Meloxicam, Celecoxib and others [16,17,18]. Authors suggest that NSAIDs have an analgesic and an anti-inflammatory effect by reducing the synthesis of arachidonic acid metabolites prostaglandins (PGE2 and PGI2) and thromboxane's (TxA2 and TxB2).…”