A Randomized, Blinded, Controlled Clinical Study of Particulate Anorganic Bovine Bone Mineral and Calcium Phosphosilicate Putty Bone Substitutes for Socket Preservation

Kotsakis, Georgios A.; Salama, Maurice; Chrepa, Vanessa; Hinrichs, James E.; Gaillard, Philippe

doi:10.11607/jomi.3230

Cited by 86 publications

(113 citation statements)

References 24 publications

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“…Some studies have been conducted to verify the effectiveness of PRP also in combination with different bone substitutes. These studies have found that PRP combined with autogenous bone provides considerably faster bone regeneration results, radiographic and histomorphometrically, besides indicating denser bone [35].Variable successful results have been demonstrated when the PRP is added to an allograft [36]. Alissa et al [37], in a pilot study on the effect of PRP on the healing of extraction sockets, reported a significantly improved soft tissue healing in patients treated with PRP compared with those of the control group (no treatment).…”

Section: Discussionmentioning

confidence: 98%

The Effects of the Combined Use of Platelet-Rich Plasma and Xenograft on Alveolar Socket Healing

Traini¹

2018

BJSTR

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Section: Discussionmentioning

confidence: 98%

The Effects of the Combined Use of Platelet-Rich Plasma and Xenograft on Alveolar Socket Healing

Traini¹

2018

BJSTR

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“…Alveolar ridge width preservation using xenograft Five studies investigated alveolar ridge bucco-oral dimension preservation using bovine derived xenograft. 24,25,26,27,28,29 Overall, all studies concluded that socket grafting with xenograft were more beneficial in terms of alveolar bone width maintenance than tooth extraction alone (weighted mean average of -1.31 mm versus -2.78mm, P <0,0001). Study results were homogeneous (I 2 = 0%, P = 0.4319).…”

Section: Description Of Included Studiesmentioning

confidence: 97%

“…In general, none of the given sources were of low risk of bias and only Kotsakis et al and Sbordone et al 24,25 conducted studies of medium risk of bias. Figure II presents the risk of bias across all studies.…”

Section: Risk Of Bias In Individual Studiesmentioning

confidence: 99%

Comparison of Bone grafts for Alveolar ridge dimensional preservation

Papečkys¹,

Rusilas²,

Pranskūnas³

2018

JIMD

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Abstract:Introduction: Alveolar bone remodeling after tooth extraction has been long considered unavoidable. Ridge resorption is greatest within 6 months. Bone dimensional changes complicate tooth replacement therapy. Recently, the use of biomaterials for ridge preservation has been researched thoroughly. The main question is whether there are any benefits of bone grafting to the extraction socket. Objectives: The aim of the study was to determine the effect that socket filling with a bone graft has on alveolar ridge volume loss as compared with tooth extraction alone. Materials and methods: A database search was conducted according to the PRISMA guidelines. We searched for studies published between 01.10.2012 and 01.10.2017. Results: Five studies investigated alveolar ridge bucco-oral dimension preservation using xenograft. Overall, the interventions with this graft were more beneficial in terms of width maintenance than tooth extraction alone. Four articles analyzed socket bucco-oral dimension maintenance using synthetic alloplast. The results were inconclusive, as 3 studies reported greater width and one article described a greater bone width in the control group. Four studies investigated the preservation of alveolar bone height after socket preservation. In the bovine derived xenograft subgroup, the effect of ridge height was greater than extraction alone. Two studies researched ridge height preservation after extraction using synthetic alloplast. The results were in favor of the test group, but were statistically insignificant. Conclusions: Alveolar ridge preservation using xenograft shows greater dimensional preservation than no graft. The results for the alloplast group were inconclusive. More and less heterogeneous studies are needed to compare these materials.

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“…Deproteinized bovine bone (DBB) is among the most widely used bone substitutes in dentistry; DBB is osteoconductive, i.e., provides a scaffold for new bone formation and facilitates space provision. Successful outcomes after DBB use, also on the long term, have been reported in numerous studies and for various indications, e.g., one-or two-stage maxillary sinus floor elevation procedures, lateral and vertical bone augmentation, and post-extraction alveolar ridge preservation [1,2,4,5].…”

Section: Introductionmentioning

confidence: 99%

Loading deproteinized bovine bone with strontium enhances bone regeneration in rat calvarial critical size defects

et al. 2018

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Objective To evaluate the effect of grafting with strontium (Sr)-loaded deproteinized bovine bone (DBB) on bone healing in calvarial critical size defects (CSD) in rats. Material and methods Two circular bone defects (5 mm in diameter) were created in the calvaria of 42 rats. One of the defects, randomly chosen, was grafted with (a) DBB, (b) DBB loaded with 19.6 μg/g of Sr (DBB/Sr1), or (c) DBB loaded with 98.1 μg/g of Sr (DBB/Sr2). The other defect was left empty as negative control. Groups of seven animals from each of the groups were euthanized 15 and 60 days post-op. Bone healing in the CSD was evaluated by micro-CT and histology/histomorphometry and immunohistochemistry.Results DBB/Sr2-grafted sites showed statistically significantly shorter radiographic residual defect length compared with DBB/ Sr1-and DBB-grafted sites, and with empty controls at 60 days. Further, the amount of new bone formation in the DBB/Sr1-and DBB/Sr2-grafted sites was significantly higher compared with that in the DBB-grafted sites at 60 days. A larger number of DBB/ Sr1-and DBB/Sr2-grafted sites presented with no-or only limited to mild inflammation, compared with the DBB-grafted sites, especially at 60 days. Higher expression of osteocalcin was observed in DBB/Sr1-and DBB/Sr2-grafted sites as compared to DBB-grafted sites. Conclusion Grafting with Sr-loaded DBB enhanced bone formation in CSD in rats, when compared with grafting with nonloaded DBB. Clinical relevance Grafting with Sr-loaded DBB may enhance bone formation in bone defects.

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A Randomized, Blinded, Controlled Clinical Study of Particulate Anorganic Bovine Bone Mineral and Calcium Phosphosilicate Putty Bone Substitutes for Socket Preservation

Cited by 86 publications

References 24 publications

The Effects of the Combined Use of Platelet-Rich Plasma and Xenograft on Alveolar Socket Healing

The Effects of the Combined Use of Platelet-Rich Plasma and Xenograft on Alveolar Socket Healing

Comparison of Bone grafts for Alveolar ridge dimensional preservation

Loading deproteinized bovine bone with strontium enhances bone regeneration in rat calvarial critical size defects

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