A randomised trial to evaluate the self-administered standardised chronic respiratory questionnaire

Abstract

The original chronic respiratory questionnaire (CRQ), one of the most widely used measures of health-related quality of life (HRQL) in chronic respiratory disease (CRD), is traditionally interviewer administered (IA) and includes an individualised dyspnoea domain. The present authors studied the impact of self-administered (SA) and standardised dyspnoea questions on CRQ measurement properties.In a factorial design multicentre trial, 177 patients with CRD (mean age 67.7 yrs; mean forced expiratory volume in one second per cent predicted 44.6%) were randomised to CRQ-IA (n586) or CRQ-SA (n591), and to initially complete the standardised or individualised items before and after respiratory rehabilitation.While maintaining validity, the CRQ-SA proved more responsive to changes in HRQL than the CRQ-IA in all domains. Compared with the standardised dyspnoea domain, the individualised dyspnoea domain indicated greater responsiveness. The correlations of baseline scores and change scores with other HRQL instruments indicated good validity of the CRQ-SA.In conclusion, self-administration and standardisation of the chronic respiratory questionnaire maintains validity and responsiveness relative to the interviewer-administered chronic respiratory questionnaire. These results challenge the assumption that interviewer-administered questionnaires are superior to self-administered questionnaires in older patients with chronic respiratory disease.

Outcomes for COPD pharmacological trials: from lung function to biomarkers

“…Effect sizes of 0.5 were found with a CRQ dyspnoea score of 0.61 units, CRQ fatigue score of 0.67 units, CRQ emotional function score of 0.60 units and CRQ mastery score of 0.60 units [116,447].…”

“…For the recommended SAS version, no specific training is required. It takes ,10 min to administer with an interviewer, compared with ,7 min for the self-administered version [115,116]. For the original CRQ instrument, an interviewer, a list of 26 activities that might cause dyspnoea and Likert scoring cards are required.…”

“…In terms of feasibility, BDI/TDI have been used to measure dyspnoea with pharmacotherapy compared with placebo in numerous RCTs performed at multiple centres [152][153][154][155][156][157][158][159][160] In addition, self-administration led to increased responsiveness compared with interviewer administration [116,117].…”

“…It includes 20 questions across four domains: dyspnoea; emotional function; fatigue; and mastery. A selfadministered standardised (SAS) version, CRQ-SAS (which takes 7 min), is available and has been validated against the original interviewer-administered version and for telephone administration [116][117][118].…”

Continuity in different care modes and its relationship to quality of life: a randomised controlled trial in patients with COPD

“…Disease-specific healthrelated quality of life was measured with the self-administered Chronic Respiratory Questionnaire (CRQ). 20 This instrument consists of 20 questions that are scored on a seven-point Likert-scale. The minimal clinically important difference of the CRQ has been established at 0.5 points.…”