A Randomised Trial Comparing Holmium Laser Enucleation Versus Transurethral Resection in the Treatment of Prostates Larger Than 40Grams: Results at 2 Years

Wilson, L.; Gilling, Peter; Williams, Andrew K.; Kennett, Katie M.; Frampton, Chris; Westenberg, Andre M.; Fraundorfer, Mark R.

doi:10.1016/j.eururo.2006.04.002

Cited by 233 publications

(155 citation statements)

References 19 publications

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“…The results of HoLEP, as evidenced by PSA data, TRUS, the weight of tissue resected, urodynamic variables and data from many randomized trials, systematic reviews and meta-analyses, confirmed the effectiveness and durability of this technique [2][3][4][5][6][7]. HoLEP reproduces the removal of the whole obstructing adenoma (transitional zone) of the prostate by surgical enucleation, similar to the technique of using the index finger in open prostatectomy.…”

Section: Introductionmentioning

confidence: 76%

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Holmium Laser Enucleation of the Prostate: Modified Technical Aspects

2010

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Section: Introductionmentioning

confidence: 76%

“…Recent studies appear to confirm that the haematuria clinic is 'fit for purpose' as 19% of patients with macroscopic haematuria investigated will have bladder cancer [2,3]. However, a significant number of patients…”

Section: Introductionmentioning

confidence: 99%

Holmium Laser Enucleation of the Prostate: Modified Technical Aspects

2010

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“…Considerable level one evidence has demonstrated the benefits of HoLEP over simple prostatectomy and TURP for the treatment of BPH in large glands [8][9][10][11][12][13][14] . Amongst established benefits of HoLEP are its long term, durable, and reproducible results that can be applied to any prostate gland size 12,15,16 Enucleation involves complete removal of the transitional zone of the prostate using a holmium-YAG laser.…”

Section: Discussionmentioning

confidence: 99%

Predictors of Enucleation and Morcellation Time During Holmium Laser Enucleation of the Prostate

Monn

Tayeb

Bhojani

et al. 2015

Urology

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Objectives: To examine predictors of enucleation and morcellation time within a large cohort of men undergoing HoLEP for benign prostatic hypertrophy.Methods: Pre-operative, peri-operative, and post-operative clinical characteristics were available from men treated with HoLEP between 1998 and 2013 at Indiana University Health Methodist Hospital. Stepwise linear regression was performed to determine clinical variables which are associated with enucleation and morcellation times. Results:We identified 960 patients who underwent HoLEP. Average (range) enucleation time was 65.7 (11-245) minutes and morcellation time was 19.7 (3-260) minutes. History of anticoagulation was associated with a small decrease in enucleation time (p=0.013) while increasing HoLEP specimen weight was associated with increasing enucleation time (p<0.001).History of intermittent catheterization, urinary tract infections, presence of dense prostatic tissue (colloquially referred to as "beach balls"), and increasing specimen weight were associated with increasing morcellation time (p<0.05 each). Having HoLEP performed by a less experienced urologist was associated with longer enucleation and morcellation times. Conclusions:Prostate volume is significantly associated with increased enucleation and morcellation times during HoLEP. Additionally, history of UTI and CIC are associated with modest increases in enucleation and morcellation times. Dense enucleated prostate tissue significantly impacts the ability to morcellate effectively. Increasing surgeon experience can significantly improve both enucleation and morcellation efficiency.3

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“…Several randomized controlled trials have clarified that HoLEP is superior to TURP [10][11][12][13] and open prostatectomy. [14][15][16] Other reports have documented that HoLEP is as durable as open prostatectomy at more than 5-year follow-up.…”

Section: Discussionmentioning

confidence: 99%

The relationship between the reproducibility of holmium laser enucleation of the prostate and prostate size over the learning curve

Haraguchi

Takenaka

Yamazaki

et al. 2009

Prostate Cancer Prostatic Dis

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The purpose of this study was to analyze the relationship between the reproducibility of holmium laser enucleation of the prostate (HoLEP) and prostate size over the learning curve. We compared the outcome among three institutions in three subgroups on the basis of the weight of tissue retrieved. There were no significant differences in operating time, efficiency of the procedure, decrease in hemoglobin level and postoperative urinary incontinence among three institutions, only in patients with prostates X20 g-o40 g retrieved. Our data indicate that HoLEP is more reproducible in patients with a moderate-sized prostate over the learning curve.

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A Randomised Trial Comparing Holmium Laser Enucleation Versus Transurethral Resection in the Treatment of Prostates Larger Than 40Grams: Results at 2 Years

Cited by 233 publications

References 19 publications

Holmium Laser Enucleation of the Prostate: Modified Technical Aspects

Holmium Laser Enucleation of the Prostate: Modified Technical Aspects

Predictors of Enucleation and Morcellation Time During Holmium Laser Enucleation of the Prostate

The relationship between the reproducibility of holmium laser enucleation of the prostate and prostate size over the learning curve

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