A randomised controlled trial to compare TIVA infusion of mixture of ketamine propofol (ketofol) and fentanyl-propofol (fentofol) in short orthopaedic surgeries

Sharma, Rajneendra; Jaitawat, Sawai Singh; Partani, Seema; Saini, Ramavtar; Sharma, Nagendra Prasad; Gupta, Shashank

doi:10.5958/2394-4994.2016.00069.x

Cited by 4 publications

(5 citation statements)

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“…This study used a low dose ketamine-propofol mixture in the ratio of 1:5 anticipating that it would be just enough to prevent fall in MAP induced by vasodilation due to propofol and also not cause too much sympathomimetic effect so as to raise MAP/TMP. This study study results were similar to 39,40 earlier studies as combination of Ketamine and propofol ( in the ratio of 1:5) provided for better maintenance of MAP during induction of anaesthesia.…”

Section: Hemodynamic Stabilitysupporting

confidence: 89%

Comparison of Ketofoland Propofol in Intracranialaneurysmal Clipping Surgery: A Prospective Randomized Control Study

Bhardwaj¹,

Garg

Arora

2020

ijsr

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Background: Haemodynamic stability is the major goal of anaesthesia during intracranial aneurysm clipping . In the present study, we compared the effects of ketofol with propofol alone, used as an induction and maintenance agent during surgical clipping of intracranial aneurysm. Material and methods - Forty patients aged 18 to 75 years, posted for aneurysm neck clipping following aneurysmal Subarachnoid haemorrhage (SAH) were included in the study. The patients were randomized into two groups. One group received combination of ketamine and propofol (1:5 ratio) (Group KP) and the other propofol (Group P) for induction and maintenance of anaesthesia. Results - Combination of Ketamine and propofol ( in the ratio of 1:5) which was used in this study provided for better maintenance of Mean Arterial Pressure(MAP) during induction and maintenance of anaesthesia. Conclusion – Ketofol compared to propofol alone provides better hemodynamic stability on induction as well as during maintenance of anaesthesia in intracranial aneurysmal clipping surgery without increasing intracranial pressure.

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Section: Hemodynamic Stabilitysupporting

confidence: 89%

Comparison of Ketofoland Propofol in Intracranialaneurysmal Clipping Surgery: A Prospective Randomized Control Study

Bhardwaj¹,

Garg

Arora

2020

ijsr

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“…While numerous studies have found that the fentP group had a higher rate of apnea, which could contribute to respiratory depression, 3,4,6,7,8,12,14 the results in our study group were not significant. As a result, a combination ketP (ketamine and propofol) may be recommended for our patients.…”

Section: Pain Intensitycontrasting

confidence: 89%

“…This could be due to ketamine's shorter duration of action. Several investigations 5,8,11,12 have found similar outcomes.…”

Section: Discussionmentioning

confidence: 62%

“…Propofol intravenous sedation is more effective and safe when administered under close patient monitoring, and it is associated with faster post-procedure recovery, however, it is well known that propofol alone is ineffective because it does not relieve pain. 7,8 Various studies 4,5,11,12 using a combination of medications for different procedures have recorded sedation and recovery responses, but little is known about ERCP in the Southeast Asian population, which was the primary goal of our investigation.…”

Section: Discussionmentioning

confidence: 99%

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Fentanyl-Propofol Versus Ketamine-Propofol Combination for Sedation and Recovery in ERCP: A Double-Blinded Randomized Clinical Trial

Javaid¹,

Riasat²,

Shah³

et al. 2023

PJMHS

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Objective: The main goal of this study was to investigate the groups receiving fentanyl-propofol (fentP) against ketamine-propofol (ketP) in ERCP in terms of sedation, rescue sedation requirement, and recovery scores. Additionally, evaluated were the procedure's hemodynamic changes, postoperative pain score, complications, and endoscopist satisfaction. Methodology: A double-blinded randomized clinical trial was undertaken at the Dr. Ruth K.M. Pfau Civil Hospital Karachi's endoscopic room (DUHS) for six months. By using OPEN EPI sample size calculator, sample size was calculated. A total of 124 patients for elective ERCP were randomized into two groups by SNOSE protocol. Groups A and B, fentanyl-propofol (fentP) and ketamine-propofol (ketP), respectively, each contain 62 patients. All patients were given a loading dose of propofol 0.5 mg/kg, followed by a 75 ug/kg/minute infusion. The group fentP received fentanyl 1ml/kg (1 ug/kg) and the group ketP received ketamine 1ml/kg (0.5mg/kg). Ramsay sedation scores, the necessity for rescue sedation, and the Aldrete score post-operatively were noted. Hemodynamics during surgery and complications were also noted. Results: Sedation began noticeably earlier than usual in the group B at 0, 2 and 4 minutes (p-value <0.05), whereas sedation scores were higher in the group A at 8,10, and 15 minutes (p-value <0.05). Early sedation in the group B led to less consumption of rescue sedation doses (p-value <0.01). However, recovery scores were comparable in each groups (p-value >0.05). Conclusion: We were able to conclude that during ERCP, ketP had a significantly faster sedative onset than fentP, with less complication and a quicker recovery. Keywords: Propofol, KetP, FentP, ketamine, fentanyl, Sedation, Analgesia, ERCP, Monitored Anesthesia care.

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“…In the study by Khutia et al, 13 hypotension occurred in 38.63% of patients in the propofol–fentanyl group compared with 14.58% in the propofol–ketamine group. Sharma et al 14 reported that respiratory depression, hypotension, and bradycardia and delayed recovery were associated with the fentofol group too. In a research done by Manickam and Mohanasundaram 15 findings showed that analgesia and sedation were better provided by ketofol.…”

Section: Discussionmentioning

confidence: 99%

Sedative and analgesic effects of propofol–ketamine versus propofol–fentanyl for emergency department procedures

Tajoddini

Motaghi²

2022

Hong Kong j. emerg. med.

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Background: To manage and reduce painful procedures in the emergency wards, procedural sedation as well as analgesia can be used. Propofol combinations are the most common short-acting intravenous sedative drugs in the field of emergency medicine. Objectives: This research aimed to compare the effectiveness, safety, and complications of intravenous infusion of ketofol with fentofol in painful emergency procedures. Methods: This study was a randomized, double-blind clinical trial. Sampling was simple and used random assignment; 196 participants were randomly assigned to two groups of 98 patients each. In each group, injection was done with fentanyl–propofol or ketamine–propofol. For data gathering, pre-procedure, and procedure, modified Aldrete’s scoring checklist was used. In order to determine the levels of sedation, we used the Ramsay Sedation Scale. Data analysis was performed via SPSS Version 20 using statistical tests such as mean ± standard division, t-test, chi-square test, and analysis of variance. Results: Among the participants in this study, shoulder procedure was performed more than other procedures (56.6%). The mean of recovery time was significantly different in the two groups (ketofol: 5.65 ± 0.35 vs fentofol: 9.33 ± 0.78); the recovery time in group B (fentofol) was longer than that in group A (ketofol) (p = 0.001). Drug complications were statistically significant in the two groups, and complications by ketofol were less than those by fentofol (p = 0.001). “Hypotension and bradycardia” were observed with fentofol and “tachycardia” was observed with ketofol. The performance of these two drugs was not the same when subject to various procedures. Conclusion: Results of this study revealed that ketofol provided better analgesia and sedation, faster recovery time, lesser complications and adverse events, and reduced bradycardia and hypotension.

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A randomised controlled trial to compare TIVA infusion of mixture of ketamine propofol (ketofol) and fentanyl-propofol (fentofol) in short orthopaedic surgeries

Cited by 4 publications

References 0 publications

Comparison of Ketofoland Propofol in Intracranialaneurysmal Clipping Surgery: A Prospective Randomized Control Study

Comparison of Ketofoland Propofol in Intracranialaneurysmal Clipping Surgery: A Prospective Randomized Control Study

Fentanyl-Propofol Versus Ketamine-Propofol Combination for Sedation and Recovery in ERCP: A Double-Blinded Randomized Clinical Trial

Sedative and analgesic effects of propofol–ketamine versus propofol–fentanyl for emergency department procedures

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