A randomised controlled trial of the effects of albendazole in pregnancy on maternal responses to mycobacterial antigens and infant responses to bacille Calmette-Guérin (BCG) immunisation [ISRCTN32849447]

Elliott, Alison M.; Namujju, Proscovia B.; Mawa, Patrice A.; Quigley, Maria A.; Nampijja, Margaret; Nkurunziza, Peter; Belisle, John T.; Muwanga, Moses; Whitworth, James

doi:10.1186/1471-2334-5-115

Cited by 47 publications

(57 citation statements)

References 24 publications

(19 reference statements)

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“…Among pregnant women enrolled in a study in Uganda, 15% were HIV-positive, 15% had malaria, 38% had hookworm, 13% had Trichuris , 6% had Ascaris , 15% had Strongyloides , and 22% had Mansonella perstans [96] . In addition, Ascaris is rarely the only parasite in an individual.…”

Section: Concurrent Infectionsmentioning

confidence: 99%

<i>Ascaris lumbricoides</i>: A Review of Its Epidemiology and Relationship to Other Infections

Scott¹

2008

Ann Nestlé [Engl]

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This review highlights advances made since 2004 in understanding the epidemiology of infection and the interactions between Ascarislumbricoides and other concurrent infections. As water scarcity increases, untreated wastewater is increasingly used to irrigate crops, thus increasing the risk of transmission. New methods to detect and inactivate Ascaris eggs in water, soil and food are described. The association between pig ownership and Ascaris infection in humans may represent cross-transmission as hybridization among the pig and human ascarids occurs more frequently than previously believed. Geospatial analyses have successfully predicted infection levels both at a regional level (based on vegetation indices, temperature and humidity) and within communities (based on social and environmental factors). The interpretation of antibody and cytokine responses to Ascaris is becoming clearer, as researchers recognize the role of antigen type, age, the history of Ascaris and other infections. The considerable interest emerging on the interactions between Ascaris and other infections (helminths, malaria, HIV, tuberculosis) and allergy is explored. The impact of concurrent infection on the design of control strategies is discussed including the benefits arising from combination therapies and the evidence that intestinal nematodes impair the efficacy of childhood vaccines. Finally, recommended areas for future research are identified.

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Section: Concurrent Infectionsmentioning

confidence: 99%

<i>Ascaris lumbricoides</i>: A Review of Its Epidemiology and Relationship to Other Infections

Scott¹

2008

Ann Nestlé [Engl]

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“…Using whole blood culture method, our birth cohort study in Indonesia found no difference in the cytokine responses to PPD after vaccination in infants up to 2 years of age, born to mothers infected or free of filarial and or geohelminth infections . Another birth cohort study with whole blood culture in Uganda showed that maternal hookworm infection was associated with reduced maternal IFN-γ responses to mycobacterial culture filtrate protein (CFP) but higher IFN-γ responses in their one-year old children (Elliott et al 2005b). Needless to say, in order to firmly establish whether helminth infections affect neonates' responses to vaccines, it would be important to conduct trials which administer anthelmintics during pregnancy.…”

Section: The Impact Of In Utero Priming By Helminth On the Infant Immmentioning

confidence: 98%

Immunological footprint: the development of a child's immune system in environments rich in microorganisms and parasites

et al. 2011

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The shaping of a child's immune system starts in utero, with possible long-term consequences in later life. This review highlights the studies conducted on the development of the immune system in early childhood up to school-age, discussing the impact that environmental factors may have. Emphasis has been put on studies conducted in geographical regions where exposure to micro-organisms and parasites are particularly high, and the effect that maternal exposures to these may have on an infant's immune responses to third-party antigens. In this respect we discuss the effect on responses to vaccines, co-infections and on the development of allergic disorders. In addition, studies of the impact that such environmental factors may have on slightly older (school) children are highlighted emphasizing the need for large studies in low to middle income countries, that are sufficiently powered and have longitudinal follow-up components to understand the immunological footprint of a child and the consequences throughout life.

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“…Indeed, helminth infection during pregnancy was shown to modulate the offspring's immune system in response to worm antigens [48] as well as unrelated vaccine antigens (e.g. BCG or tetanus toxoid) [71,72].…”

Section: Schistosomiasismentioning

confidence: 99%

Maternal Helminth Infections

Straubinger

Costa

2014

How Helminths Alter Immunity to Infection

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A randomised controlled trial of the effects of albendazole in pregnancy on maternal responses to mycobacterial antigens and infant responses to bacille Calmette-Guérin (BCG) immunisation [ISRCTN32849447]

Abstract: Background: Maternal schistosomiasis and filariasis have been shown to influence infant responses to neonatal bacille Calmette-Guérin (BCG) immunisation but the effects of maternal hookworm, and of de-worming in pregnancy, are unknown.

Cited by 47 publications

References 24 publications

<i>Ascaris lumbricoides</i>: A Review of Its Epidemiology and Relationship to Other Infections

<i>Ascaris lumbricoides</i>: A Review of Its Epidemiology and Relationship to Other Infections

Immunological footprint: the development of a child's immune system in environments rich in microorganisms and parasites

Maternal Helminth Infections

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