A randomised controlled trial of opioid only versus combined opioid and non-steroidal anti inflammatory analgesics for pain relief in the first 48 hours after Caesarean section

Adamou, Natalia; Tukur, Jamilu; Muhammad, Zakari; Galadanci, Hadiza

doi:10.4103/0300-1652.140319

Cited by 12 publications

(27 citation statements)

References 7 publications

(12 reference statements)

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“…20 The sedative effect of pentazocine was maintained across all groups and was greater in the pentazocine+piroxicam group with no untoward adverse reaction. No adverse reaction was recorded in any breastfed neonates, which is similar to the findings of another study.…”

mentioning

confidence: 84%

Pentazocine versus pentazocine with piroxicam for postoperative pain relief after cesarean section: an open label, comparative study

Ambika

Mamatha

Prabha

2017

Int J Basic Clin Pharmacol

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Background: The concept of multimodal analgesia was introduced more than a decade ago as a technique to improve analgesia and reduce the incidence of opioid-related adverse events. The rationale for this strategy is the achievement of sufficient analgesia due to the additive or synergistic effects between different classes of analgesics. Objectives of the study was to compare the efficacy and safety of pentazocine and its combination with piroxicam in the management of post cesarean pain.Methods: Cases were randomly assigned to 2 groups of 30 cases each. One group received pentazocine 30mg and another; pentazocine 30mg + piroxicam 20mg. Injections were given intramuscularly, postoperatively after skin closure. Diclofenac 75mg was the rescue analgesia. Primary outcome measure was control of pain, assessed by visual analogue scale (VAS). Secondary outcomes were sedation and time to rescue analgesia. Safety of the drugs was assessed by adverse drug reactions. Data was analysed by student’s t test, analysis of variance and post-hoc test.Results: Multimodal group showed better analgesia compared to unimodal group (p<0001). Drowsiness was the main adverse effect in both treatment groups.Conclusions: Multimodal analgesic combination of pentazocine and piroxicam showed superior analgesic effect with better pain control and longer duration of action compared to pentazocine alone.

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mentioning

confidence: 84%

Pentazocine versus pentazocine with piroxicam for postoperative pain relief after cesarean section: an open label, comparative study

Ambika

Mamatha

Prabha

2017

Int J Basic Clin Pharmacol

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“…Egede et al (12) reported that up to 45% of the study participants in his study, initiated breast-feeding after 12 hours post-operative while Adamou et al (10) in Kano found that the mean duration of initiation of breastfeeding as high as 22.2 ± 6.9 hours. This duration of initiation of breast-feeding is markedly higher than that recommended by Word Health Organization for baby friendly Hospital initiative which recommended initiation of breast-feeding within 1 hour after delivery.…”

mentioning

confidence: 87%

“…A study by Eleje et al in Rivers state have reported that up to 94% of patients hat had caesarean section began independent mobilization after 24 hours postoperative (13). The mean duration of ambulation following caesarean section was found to be 18.6 ± 2.4 hours in Abakaliki, Ebonyi state (12) while it was found to be 22 ± 6.38 in Kano (10). This delay in ambulation following caesarean section could affect the emotional and psychological wellbeing of women.…”

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confidence: 93%

“…The rationale for using multi-modal methods is the achievement of satisfactory analgesia by synergistic effects between different classes of drugs and the incidence of side effects from any of the drugs used could be reduced since there is room for a reduction in the doses of individual drugs (9). A lower incidence of side effects and improved pain relief has been demonstrated with multi-modal analgesia methods (10)(11)(12)(13). This may provide improved recovery, shorter hospital stay and possibly decreased healthcare costs.…”

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confidence: 99%

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Post-operative Experience following Caesarean Section in a Nigerian Obstetric Population

Garba¹,

Panti²,

Ahmed³

et al. 2021

ABMS

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Background: Caesarean section is the most significant obstetrics operative intervention globally. Good postoperative experience after caesarean section is important because there is need for the mother to recover from surgery and take care of her baby. The aim of this study was to assess the experience of women that had caesarean section in the first 24 hours postoperatively. Materials/methods: This was a cross-sectional study conducted among women that had elective and emergency caesarean section. They were followed up to 24 hours post-operative. The primary outcome measures were pain score and satisfaction. Secondary outcome measures were time of mobilization, time of commencement of oral feeds and time of initiation of breastfeeding. Data analysis was carried out using Statistical Package for Social Sciences version 22. Results: The median pain scores among those that had emergency and elective caesarean section ranged between 2 and 3 at all points of pain assessment. The satisfaction was good among 66.1% that had emergency caesarean section and 71.2% among those that had elective caesarean section. However, the difference was not statistically significant (χ2 = 0.546, p = 0.761). More than 90% of the participants that had either emergency or elective caesarean section did not ambulate within the first 24 hours after caesarean section and there was no association between the time of ambulation and the type of caesarean section (χ2 = 0.005, p = 0.941). Conclusion: The participants had adequate pain relief and majority were satisfied with the pain relief. However, the optimum satisfaction was not achieved. The participants did not ambulate early and did not initiate breast-feeding early. Recommendation: Further research is recommended to assess other factors that affect patient's satisfaction and ambulation so as to improve on patient's postoperative care.

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“…La asociación de mayor tiempo y calidad de analgesia postoperatoria redunda en una mayor satisfacción subjetiva por parte del paciente, que se siente beneficiado con la aplica-ción de esquemas terapéuticos cada vez más efectivos, como quedó demostrado en el estudio, coincidente con Hefni y su grupo (26) , Graudins y colegas (27) y Adamou y colaboradores (28) que señalan satisfacción subjetiva en pacientes tratados con opioides para el control del dolor.…”

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Fentanyl-bupivacaína y bupivacaína en intervenciones quirúrgicas

Piñón-García¹,

Valladares-Díaz²,

Correa-Borrell³

et al. 2020

Revista Mexicana De Anestesiología

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A randomised controlled trial of opioid only versus combined opioid and non-steroidal anti inflammatory analgesics for pain relief in the first 48 hours after Caesarean section

Cited by 12 publications

References 7 publications

Pentazocine versus pentazocine with piroxicam for postoperative pain relief after cesarean section: an open label, comparative study

Pentazocine versus pentazocine with piroxicam for postoperative pain relief after cesarean section: an open label, comparative study

Post-operative Experience following Caesarean Section in a Nigerian Obstetric Population

Fentanyl-bupivacaína y bupivacaína en intervenciones quirúrgicas

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